Gouryst 0.5 mg 100 tab

Gouryst 0.5 mg 100 tab

Description:

Gouryst 0.5 mg 100 tab is a prescription oral medicine containing colchicine, used primarily for the treatment and prevention of gout attacks and other inflammatory conditions. Each tablet delivers 0.5 mg of colchicine, an anti-inflammatory agent that works by inhibiting microtubule polymerization in white blood cells, thereby reducing lactic acid production, uric acid crystal deposition, and the inflammatory response in joints and tissues. Manufactured by Pharopharma, Gouryst is commonly used in rheumatology and internal medicine for conditions such as acute gout, familial Mediterranean fever, and certain types of arthritis and pericarditis. It should be used strictly under medical supervision due to its narrow therapeutic index and potential toxicity at higher doses.

Indications:

• Acute gout attacks: rapid relief of pain, redness, and swelling in affected joints.
• Gouty arthritis: management and prevention of recurrent gout flares.
• Familial Mediterranean fever (FMF): reduction of inflammatory attacks and prevention of amyloidosis as prescribed by a physician.
• Amyloidosis: adjunctive therapy in selected cases as directed by a specialist.
• Behcet's syndrome: management of inflammatory joint manifestations as recommended by a rheumatologist.
• Calcium pyrophosphate deposition disease (pseudogout): relief of acute attacks and prevention of recurrences.
• Cirrhosis-related conditions: selected inflammatory complications as indicated by a hepatologist.
• Pericarditis: treatment and prevention of recurrent pericarditis as part of a specialist-guided regimen.
• Sarcoid arthritis: management of inflammatory joint symptoms in selected patients.
• Immunosuppressive/anti-inflammatory agent in specific autoimmune or inflammatory disorders as determined by a physician.

Active Ingredients / Key Components:

• Colchicine – 0.5 mg per tablet
• Excipients: information on inactive ingredients (such as fillers, binders, and coloring agents) is not available in the provided data. Please refer to the package insert for a complete list of excipients.

Dosage & Administration / How to Use:

• Use only as prescribed by a physician. Dosage may vary depending on indication, age, kidney and liver function, and concomitant medications.
• Acute gout attack (typical adult regimen – may vary by guideline and prescriber): an initial dose followed by smaller doses at intervals may be prescribed. Do not exceed the total daily dose recommended by your doctor. High or repeated dosing without supervision can cause serious toxicity.
• Prevention of gout flares / chronic gouty arthritis: usually a low daily dose (once or twice daily) as directed by the physician.
• Familial Mediterranean fever and other chronic inflammatory conditions: taken regularly every day at a dose individualized by the specialist.
• Tablets are taken orally with a glass of water, with or without food. Taking with food may help reduce gastrointestinal discomfort.
• Swallow tablets whole; do not crush or chew unless your doctor or pharmacist advises otherwise.
• If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to make up for a missed dose.
• Do not change your dose or stop treatment abruptly without consulting your doctor, especially in familial Mediterranean fever or recurrent pericarditis.
• Patients with kidney or liver impairment, elderly patients, and those taking interacting medicines (e.g., certain antibiotics, antifungals, or heart medications) often require lower doses and close monitoring.

Clinical Benefits:

• Rapidly reduces pain, swelling, and redness in acute gout attacks by suppressing inflammatory cell activity in the joints.
• Helps prevent recurrent gout flares and gouty arthritis when used as maintenance therapy under medical supervision.
• Decreases lactic acid production by leukocytes and reduces uric acid crystal deposition, contributing to better long-term joint health.
• Provides effective control of inflammatory episodes in familial Mediterranean fever and selected autoimmune or inflammatory conditions, helping reduce complications such as amyloidosis.

Warnings & Contraindications:

• Colchicine has a narrow therapeutic index; even small overdoses can be toxic or life-threatening. Never exceed the prescribed dose.
• Contraindicated in patients with severe renal or hepatic impairment unless specifically adjusted and monitored by a specialist.
• Contraindicated in patients with known hypersensitivity to colchicine or any component of the formulation.
• Use with extreme caution in elderly or frail patients, and in those with gastrointestinal, cardiac, blood, kidney, or liver disorders.
• Serious drug interactions may occur with strong CYP3A4 inhibitors and P-glycoprotein inhibitors (e.g., certain macrolide antibiotics, azole antifungals, some HIV medications). Inform your doctor about all medicines, supplements, and herbal products you are taking.
• Prolonged use or high doses may cause bone marrow suppression, leading to low white blood cells, anemia, or thrombocytopenia.
• Consult your doctor before use if pregnant or planning pregnancy. Colchicine should be used in pregnancy only if clearly needed and prescribed by a specialist.
• If breastfeeding, consult your healthcare provider before use; colchicine can pass into breast milk.
• Use with caution in patients with gastrointestinal diseases (e.g., peptic ulcer, severe diarrhea) as colchicine commonly causes GI side effects.
• Avoid alcohol excess, as it may trigger gout attacks and increase gastrointestinal irritation.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical supervision and prescription.
• Keep out of reach of children. Accidental ingestion by children can be fatal; seek emergency medical help immediately if overdose is suspected.

Side Effects:

• Common side effects: nausea, vomiting, abdominal pain or cramps, diarrhea, loss of appetite. These are dose-related and may improve with dose reduction as directed by your doctor.
• Less common side effects: fatigue, headache, muscle pain or weakness, hair loss, skin rash.
• Serious side effects (seek immediate medical attention): severe or persistent vomiting or diarrhea, blood in stool or vomit, extreme weakness, muscle pain or dark urine (possible muscle breakdown), numbness or tingling, signs of infection such as fever or sore throat (possible low white blood cells), easy bruising or bleeding, yellowing of skin or eyes (liver problems), decreased urination or swelling of legs (kidney problems).
• In case of suspected overdose (e.g., taking more tablets than prescribed), seek emergency medical care immediately, even if no symptoms appear at first.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Active ingredient: colchicine 0.5 mg per tablet
• Form: oral tablets
• Pack size: 100 tablets per pack
• Intended use: prescription anti-inflammatory medicine for gout and specific inflammatory conditions

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.