Amaryl M 500 Mg 20 Tablets

Amaryl M 500 Mg 20 Tablets

Description:

Amaryl M 500 mg 20 tablets is an oral antidiabetic prescription medicine used to help control blood glucose levels in adults with type 2 diabetes mellitus. It is a fixed-dose combination of glimepiride (a third-generation sulfonylurea) and metformin (a biguanide), two complementary agents that work together to improve insulin secretion and insulin sensitivity. Amaryl M is typically used when diet, exercise, and metformin or sulfonylurea alone are not sufficient to achieve adequate glycemic control. It is part of comprehensive diabetes care to reduce the risk of diabetes-related complications when used under medical supervision.

Indications:

• Management of type 2 diabetes mellitus in adults when blood glucose levels are not adequately controlled by diet, exercise, and monotherapy with metformin or glimepiride alone.
• Helps reduce elevated fasting and postprandial (after-meal) blood glucose levels.
• Used as part of a comprehensive diabetes management plan including lifestyle modification (diet and physical activity).

Active Ingredients / Key Components:

• Glimepiride – exact strength per tablet is not specified in the provided product name. In Egypt, Amaryl M combinations commonly contain glimepiride plus metformin, but the precise glimepiride dose for this specific "Amaryl M 500 mg 20 tablets" pack is not available in the given information.
• Metformin hydrochloride – 500 mg per tablet (as indicated by the product name).
• Other inactive ingredients (excipients) are present to form the film-coated tablet; detailed excipient list and concentrations are not available in the provided data.

Dosage & Administration / How to Use:

• Dosage must always be individualized by the treating physician based on blood glucose levels, previous therapy, and patient response.
• Amaryl M is usually taken once or twice daily with meals to reduce gastrointestinal side effects and the risk of hypoglycemia. Follow your doctor’s exact instructions.
• Swallow the tablets whole with a glass of water. Do not crush or chew unless your doctor or pharmacist specifically advises otherwise.
• Take the medicine at the same time(s) each day, usually with breakfast and/or the main meal, to maintain consistent blood glucose control.
• Do not skip meals when taking Amaryl M, as this may increase the risk of low blood sugar (hypoglycemia).
• If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not double the dose to make up for a missed dose. Consult your doctor for specific guidance.
• Do not change the dose or stop the medication without consulting your healthcare provider, even if you feel better.

Clinical Benefits:

• Provides dual mechanism of action: glimepiride increases insulin release from pancreatic beta cells, while metformin improves insulin sensitivity and reduces hepatic glucose production.
• Helps achieve better glycemic control in type 2 diabetes compared to monotherapy in suitable patients, contributing to lower fasting and postprandial blood glucose levels.
• Supports long-term reduction in the risk of diabetes-related complications (such as neuropathy, nephropathy, and retinopathy) when used as part of comprehensive diabetes management.
• Convenient fixed-dose combination may improve treatment adherence by reducing the number of tablets needed compared with taking glimepiride and metformin separately.

Warnings & Contraindications:

• Contraindicated in patients with type 1 diabetes mellitus, diabetic ketoacidosis, or diabetic pre-coma.
• Contraindicated in patients with severe renal impairment or significant kidney dysfunction, and in conditions that may affect kidney function (e.g., severe dehydration, severe infection, shock). Metformin can increase the risk of lactic acidosis in such situations.
• Contraindicated in patients with severe hepatic impairment or significant liver disease.
• Do not use in patients with known hypersensitivity or allergy to glimepiride, other sulfonylureas, sulfonamides, metformin, or any component of the formulation.
• Use with caution in elderly patients, those with adrenal or pituitary insufficiency, malnourished or debilitated patients, or those with irregular food intake, as they are at higher risk of hypoglycemia.
• Excessive alcohol intake (acute or chronic) increases the risk of lactic acidosis with metformin and may potentiate hypoglycemia with glimepiride. Avoid alcohol or limit intake strictly as advised by your doctor.
• Before surgery or imaging procedures involving iodinated contrast media, your doctor may advise temporarily stopping metformin-containing products to reduce the risk of lactic acidosis.
• Consult your doctor before use if pregnant, planning pregnancy, or breastfeeding. Insulin is usually preferred during pregnancy; Amaryl M is generally not recommended unless specifically directed by a specialist.
• Consult your doctor before use if you have kidney disease, liver disease, heart failure, recent heart attack, severe infection, dehydration, or respiratory problems.
• Monitor blood glucose regularly as directed. Be aware of symptoms of hypoglycemia (sweating, tremor, hunger, dizziness, palpitations) and hyperglycemia (increased thirst, frequent urination, fatigue).
• Not intended to diagnose, treat, cure, or prevent any disease without medical supervision; it is a prescription antidiabetic medicine and must be used only under a healthcare provider’s guidance.
• Keep out of reach of children.

Side Effects:

• Common side effects: gastrointestinal disturbances such as nausea, vomiting, diarrhea, abdominal discomfort, and loss of appetite (mainly due to metformin), especially at the start of therapy. These often improve with continued use or dose adjustment.
• Hypoglycemia (low blood sugar) may occur, particularly if meals are skipped, caloric intake is reduced, intense physical exercise is not compensated with additional carbohydrate intake, or when combined with other antidiabetic drugs. Symptoms include sweating, shakiness, hunger, headache, dizziness, confusion, and palpitations.
• Less common side effects: taste disturbances, skin reactions such as rash, itching, or redness; mild weight changes; headache or dizziness.
• Rare but serious side effects: lactic acidosis (a medical emergency) associated with metformin, especially in patients with significant kidney or liver impairment or conditions causing hypoxia. Symptoms include deep and rapid breathing, severe weakness, abdominal pain, muscle cramps, and feeling very unwell. Seek immediate medical attention if suspected.
• Severe allergic reactions (angioedema, difficulty breathing, severe skin reactions) are rare but require urgent medical attention.
• If you experience persistent, severe, or unusual symptoms, contact your doctor or pharmacist promptly.

Storage Instructions:

Store in a cool, dry place away from direct sunlight and moisture. Keep the blister pack in the original outer carton to protect from light. Do not store above the temperature specified on the package (exact temperature not provided in the available information (For full ingredient information, please check the product leaflet or the manufacturer’s official website.); follow pack instructions). Keep container tightly closed and keep out of reach of children.

Specifications:

• Product type: Prescription oral antidiabetic medicine (combination of sulfonylurea and biguanide).
• Form: Film-coated tablets.
• Strength: Metformin hydrochloride 500 mg per tablet; glimepiride strength not specified in the provided data.
• Pack size: 20 tablets per pack.
• Route of administration: Oral.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.