Anafronil Sr 75 Mg 20 Tablets

Anafronil Sr 75 Mg 20 Tablets

Description:

Anafronil sr 75 mg 20 tablets is a prescription antidepressant medicine containing clomipramine, a tricyclic antidepressant (tertiary amine) with strong anti-obsessional properties. It is formulated as sustained-release (sr) film-coated tablets to provide gradual release of the active ingredient over time, helping maintain stable blood levels with once-daily dosing. Anafronil sr is primarily used in the treatment of major depressive disorders and obsessive compulsive disorder (ocd), and as an adjunctive treatment of cataplexy associated with narcolepsy. This product is intended for adult use under strict medical supervision.

Indications:

• Treatment of major depressive episodes and depressive disorders, including symptoms such as persistent low mood, loss of interest, fatigue, sleep disturbances, and impaired concentration (as prescribed by a psychiatrist or physician).
• Treatment of obsessive compulsive disorder (ocd), including recurrent intrusive thoughts (obsessions) and repetitive behaviors (compulsions) that interfere with daily functioning.
• Adjunctive treatment of cataplexy associated with narcolepsy, helping reduce sudden episodes of muscle weakness triggered by emotions (as part of a comprehensive narcolepsy management plan).
• Management of associated anxiety symptoms in patients with depression or ocd, when judged appropriate by the treating physician.

Active Ingredients / Key Components:

• Clomipramine hydrochloride – 75 mg per sustained-release film-coated tablet (tricyclic antidepressant, anti-obsessional agent).
• Excipients: The full list of inactive ingredients (tablet core and film-coating components, such as fillers, binders, colorants, and coating agents) is not available in the provided information. Please refer to the official package leaflet for the complete excipient list.

Dosage & Administration / How to Use:

• Anafronil sr 75 mg must be used exactly as prescribed by your doctor. Do not adjust the dose or stop the medication without medical advice.
• General adult dosing (immediate-release reference): For depression, treatment is usually started at 10 mg at night and gradually increased up to 150 mg per day in divided doses or as a single night dose. Maintenance doses are typically 30–50 mg daily. Maximum dose can reach 250 mg per day in adults, under close medical supervision. For obsessive compulsive disorder, initial dose is often 25 mg at night, increased gradually up to around 150 mg per day in divided doses or as a single night dose, according to response and tolerability.
• For Anafronil sr 75 mg specifically: The sustained-release formulation is usually taken once daily, preferably in the evening or as directed by the physician. The exact daily dose (number of tablets) and duration of therapy are determined individually by the doctor based on the condition, severity, and patient response.
• Swallow the tablets whole with a sufficient amount of water. Do not crush, chew, or break the sustained-release tablets, as this may affect the controlled release of the medicine.
• Can be taken with or without food, but try to take it at the same time each day to maintain consistent blood levels.
• If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to make up for a missed one.
• Long-term use may be required in depression and ocd. Treatment should be tapered gradually when discontinuing to reduce the risk of withdrawal symptoms, strictly under medical supervision.
• Not recommended for children and adolescents unless specifically prescribed by a specialist, due to safety considerations and the need for close monitoring.

Clinical Benefits:

• Helps relieve symptoms of major depression by increasing the levels of serotonin (5-ht) and noradrenaline in the central nervous system, improving mood, motivation, and overall emotional balance.
• Provides strong anti-obsessional effects, reducing the frequency and intensity of intrusive thoughts and compulsive behaviors in patients with obsessive compulsive disorder.
• Assists in the management of cataplexy associated with narcolepsy, helping decrease sudden episodes of muscle weakness and improving daily functioning.
• Sustained-release (sr) formulation offers gradual release of clomipramine, supporting more stable plasma concentrations, potentially improved tolerability, and convenient once-daily dosing.

Warnings & Contraindications:

• Use only under medical supervision. This is a prescription-only medicine.
• Contraindications: Do not use Anafronil sr if you are allergic to clomipramine, other tricyclic antidepressants, or any of the excipients; if you are currently taking or have taken monoamine oxidase inhibitors (maois) within the last 14 days; if you have recently had a myocardial infarction; or if you have severe cardiac conduction disorders. Always confirm contraindications with your doctor and the official leaflet.
• Use with extreme caution in patients with a history of cardiovascular disease (arrhythmias, heart failure, conduction disorders), liver disease, kidney impairment, glaucoma (especially narrow-angle glaucoma), urinary retention, prostatic hypertrophy, epilepsy or seizure disorders, hyperthyroidism, or those taking thyroid medication.
• May increase the risk of suicidal thoughts and behavior, particularly at the beginning of treatment or when doses are changed, especially in young adults. Close monitoring by family and healthcare providers is essential.
• Can cause drowsiness, dizziness, blurred vision, and impaired concentration. Avoid driving, operating machinery, or performing hazardous tasks until you know how the medicine affects you.
• May interact with many other medicines, including maois, ssris, snris, other antidepressants, antipsychotics, antiarrhythmics, antihypertensives, anticoagulants, antiepileptics, and certain antibiotics. Inform your doctor and pharmacist about all medicines, supplements, and herbal products you are taking.
• Alcohol should be avoided, as it can enhance drowsiness and other central nervous system side effects.
• Consult your doctor before use if pregnant, planning pregnancy, or nursing. Clomipramine should be used during pregnancy or breastfeeding only if the potential benefit justifies the potential risk to the fetus or infant.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical supervision and prescription.
• Keep out of reach of children.
• Do not stop taking Anafronil sr suddenly without consulting your doctor, as this may cause withdrawal symptoms such as nausea, headache, malaise, and sleep disturbances.

Side Effects:

• Common side effects: Dry mouth, constipation, nausea, vomiting, abdominal discomfort, increased sweating, dizziness, drowsiness, fatigue, tremor, headache, blurred vision, weight gain or loss, and changes in appetite. These are often dose-related and may decrease as treatment continues.
• Cardiovascular effects: Palpitations, tachycardia (fast heartbeat), orthostatic hypotension (drop in blood pressure when standing), and changes in heart conduction (seen on ecg). Patients with heart disease require close monitoring.
• Neuropsychiatric effects: Agitation, anxiety, confusion (especially in elderly), insomnia, restlessness, mood changes, or, rarely, seizures in predisposed individuals.
• Serious side effects (seek immediate medical attention): Severe allergic reactions (rash, itching, swelling of face or throat, difficulty breathing), severe dizziness or fainting, chest pain, irregular heartbeat, seizures, signs of serotonin syndrome (fever, agitation, muscle rigidity, rapid heartbeat), or signs of liver problems (yellowing of skin or eyes, dark urine, persistent nausea).
• If any side effects are severe, persistent, or worrying, or if you notice any unusual symptoms, contact your doctor or pharmacist promptly.

Storage Instructions:

Store in a cool, dry place away from direct sunlight and moisture. Keep the blister pack or original container tightly closed. Do not store above the temperature indicated on the package (specific temperature information is not available here; please check the official pack). Keep out of reach and sight of children. Do not use after the expiry date printed on the pack. Do not use if the blister is damaged or tablets appear deteriorated.

Specifications:

• Product type: Prescription antidepressant medicine (tricyclic antidepressant, anti-obsessional).
• Active ingredient strength: Clomipramine hydrochloride 75 mg per sustained-release film-coated tablet.
• Form: Sustained-release (sr) film-coated tablets.
• Pack size: 20 tablets per pack.
• Intended users: Adults, under physician supervision.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.