Avivavasc 5/160 Mg

Avivavasc 5/160 Mg

Description:

Avivavasc 5/160 mg film-coated tablets are a prescription antihypertensive medicine combining two active substances, amlodipine and valsartan. It is used for the treatment of high blood pressure (hypertension) in adults who require combination therapy to achieve adequate blood pressure control. By combining a calcium channel blocker (amlodipine) with an angiotensin II receptor blocker (valsartan), Avivavasc 5/160 mg helps relax and widen blood vessels, lower blood pressure, and reduce the risk of serious cardiovascular events such as stroke and heart attack when used as part of a comprehensive cardiovascular risk management plan.

Indications:

• Treatment of essential hypertension (high blood pressure) in adults.
• Patients whose blood pressure is not adequately controlled on amlodipine or valsartan alone and who require a fixed-dose combination.
• Management of persistently elevated blood pressure to help reduce the risk of cardiovascular complications such as stroke, myocardial infarction (heart attack), and other target-organ damage when used according to current treatment guidelines.

Active Ingredients / Key Components:

• Amlodipine (as amlodipine besylate) – 5 mg per film-coated tablet.
• Valsartan – 160 mg per film-coated tablet.
• Other excipients: Full list of inactive ingredients (excipients, colorants, coating agents, preservatives) is not available in the provided information. Please refer to the official package leaflet for the complete composition.

Dosage & Administration / How to Use:

• Avivavasc 5/160 mg is for oral use only and should be taken exactly as prescribed by your physician.
• Usual dose: One tablet once daily, preferably taken at the same time each day. The exact dose and strength may be adjusted by the doctor based on blood pressure response and clinical condition.
• Tablets should be swallowed whole with a glass of water. Do not crush, chew, or break the tablets.
• Avivavasc 5/160 mg may be taken with or without food. Taking it consistently with regard to meals is recommended for routine use.
• If a dose is missed, take it as soon as you remember on the same day. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
• Do not stop taking Avivavasc without consulting your doctor, even if you feel well, as high blood pressure often has no symptoms.
• Use in children and adolescents: Safety and efficacy in patients under 18 years have not been established; use only if specifically directed by a specialist.

Clinical Benefits:

• Provides effective blood pressure reduction by combining two complementary mechanisms of action (calcium channel blockade and angiotensin II receptor blockade).
• Helps relax and widen blood vessels, improving blood flow and reducing strain on the heart.
• Supports long-term management of hypertension, which may reduce the risk of stroke, heart attack, and other cardiovascular events when used as part of guideline-directed therapy.
• Fixed-dose combination in a single tablet may improve treatment adherence compared with taking separate medications.

Warnings & Contraindications:

• Contraindicated in patients with known hypersensitivity to amlodipine, valsartan, other dihydropyridine calcium channel blockers, or any of the excipients.
• Contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of injury and death to the developing fetus associated with drugs acting on the renin-angiotensin system.
• Contraindicated in patients with severe hepatic impairment, biliary cirrhosis, or cholestasis, unless specifically assessed and approved by a specialist.
• Use with caution in patients with renal impairment, renal artery stenosis, recent kidney transplant, or conditions predisposing to kidney dysfunction. Regular monitoring of renal function and serum potassium is recommended.
• Use with caution in patients with heart failure, recent myocardial infarction, aortic stenosis, or other obstructive cardiac disorders, as amlodipine may increase the risk of hypotension or worsening heart failure in susceptible individuals.
• Concomitant use with potassium-sparing diuretics, potassium supplements, or potassium-containing salt substitutes may increase the risk of hyperkalemia; monitor potassium levels when such combinations are necessary.
• May cause symptomatic hypotension, especially in volume- or salt-depleted patients (e.g., those on high-dose diuretics, with diarrhea or vomiting). Correct volume depletion before starting therapy when possible.
• Consult your doctor before use if pregnant, nursing, planning pregnancy, taking other antihypertensives, diuretics, NSAIDs, lithium, or have medical conditions such as liver disease, kidney disease, heart failure, diabetes, or electrolyte imbalances.
• Not intended to diagnose, treat, cure, or prevent any disease outside its approved indications. Use only under medical supervision.
• Keep out of reach of children.
• Do not drive or operate machinery if you experience dizziness, fatigue, or visual disturbances after taking this medicine.

Side Effects:

• Common side effects may include dizziness, headache, flushing, palpitations, ankle or leg swelling (peripheral edema), fatigue, and mild gastrointestinal discomfort (nausea, abdominal pain).
• Less common side effects can include low blood pressure (hypotension), rapid heartbeat (tachycardia), muscle cramps, joint pain, or rash.
• Serious but rare side effects may include severe hypotension, angioedema (swelling of the face, lips, tongue, or throat), chest pain, worsening heart failure, or significant changes in kidney function or potassium levels.
• Seek immediate medical attention if you experience difficulty breathing, severe dizziness or fainting, chest pain, or swelling of the face, lips, tongue, or throat.
• This is not a complete list of side effects. For full safety information, refer to the patient information leaflet and consult your healthcare provider.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed in the original blister and carton to protect from moisture. Keep out of reach of children.

Specifications:

• Strength: Amlodipine 5 mg + valsartan 160 mg per film-coated tablet.
• Form: Film-coated tablets for oral administration.
• Pack size: 28 film-coated tablets per pack (28 f.c. tabs.).
• Intended use: Prescription antihypertensive medicine for adults.
• Manufacturer: Marcyrl Pharmaceutical Industries (MPI).

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.