Azathioprine Rpg 50Mg 100 Tab

Azathioprine Rpg 50 Mg 30 Tablets

Description:

Azathioprine Rpg 50 mg 30 tablets is a prescription immunosuppressant medicine containing azathioprine, used to reduce immune system activity in various autoimmune diseases and to help prevent organ transplant rejection. It works by antagonizing purine metabolism, inhibiting the synthesis of DNA, RNA and proteins, and suppressing cellular immunity, particularly affecting leukocytes and lymphocytes. This medication is typically used as part of long-term management plans under strict medical supervision and is not a self-medication product.

Indications:

• Prevention of rejection in kidney transplant recipients (as part of immunosuppressive therapy).
• Rheumatoid arthritis inadequately controlled by conventional therapy.
• Ulcerative colitis and Crohn's disease (inflammatory bowel disease) for induction and maintenance of remission.
• Autoimmune liver diseases including cirrhosis and chronic active hepatitis (e.g., hepatitis C–related immune conditions) as directed by a specialist.
• Systemic lupus erythematosus and related connective tissue diseases.
• Dermatomyositis, myopathy and other autoimmune muscle disorders.
• Myasthenia gravis (autoimmune neuromuscular disease).
• Nephritic syndrome and other immune-mediated kidney diseases.
• Autoimmune blistering skin diseases such as pemphigus and pemphigoid.
• Severe atopic dermatitis and chronic cutaneous vasculitis or cutaneous polyarteritis nodosa, when other treatments are inadequate.
• Immune-mediated hematologic disorders such as immune-mediated hemolytic anemia and immune-mediated platelet destruction (immune thrombocytopenia), as prescribed by a hematologist.

Active Ingredients / Key Components:

• Azathioprine – 50 mg per tablet.
• Excipients: Exact inactive ingredients (e.g., fillers, binders, coloring agents) are not specified in the available information (For full ingredient information, please check the product leaflet or the manufacturer’s official website.) and may vary by manufacturer. Please refer to the package insert for the full excipient list.

Dosage & Administration / How to Use:

• Azathioprine Rpg 50 mg is to be used only under the supervision of a physician experienced in immunosuppressive therapy.
• Typical adult doses vary widely depending on indication, body weight, and concomitant medications. The usual daily dose often ranges from approximately 1–3 mg/kg/day, but your doctor will determine the exact dose for you.
• Tablets are usually taken once or twice daily, at the same time each day, with a glass of water.
• Can be taken with food to help reduce gastrointestinal upset, unless your doctor advises otherwise.
• Do not crush or chew the tablets unless specifically instructed by your doctor or pharmacist.
• Dosage adjustments are often required in patients with kidney or liver impairment and when used with allopurinol or other interacting medicines.
• Regular blood tests (complete blood count, liver function tests, kidney function) are mandatory to monitor for bone marrow suppression and organ toxicity.
• Do not change the dose, stop, or restart treatment without consulting your doctor.
• If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to make up for a missed tablet.

Clinical Benefits:

• Helps prevent rejection of kidney transplants by suppressing the immune response against the transplanted organ.
• Reduces inflammation and disease activity in autoimmune conditions such as rheumatoid arthritis, lupus, and inflammatory bowel disease.
• Decreases the frequency and severity of flares in chronic immune-mediated skin, muscle, and vascular disorders.
• Supports long-term disease control, potentially reducing the need for high-dose corticosteroids and their associated side effects.

Warnings & Contraindications:

• Azathioprine can cause serious bone marrow suppression leading to low white blood cells, red blood cells, and platelets. Regular blood monitoring is essential.
• May increase the risk of serious infections due to immune suppression. Avoid contact with people who have contagious infections and report signs of infection (fever, sore throat, cough, unusual fatigue) immediately.
• Long-term use may increase the risk of certain malignancies, particularly lymphomas and skin cancers. Use sun protection and attend regular medical follow-up.
• Contraindicated in patients with known hypersensitivity to azathioprine or 6-mercaptopurine.
• Use with extreme caution in patients with liver disease, kidney impairment, or known thiopurine methyltransferase (TPMT) or NUDT15 deficiency. Dose adjustment or alternative therapy may be required.
• Concomitant use with allopurinol, febuxostat, or other xanthine oxidase inhibitors requires major dose reduction and close monitoring due to risk of severe toxicity.
• Live vaccines should generally be avoided during treatment; discuss vaccination plans with your doctor.
• Pregnancy & breastfeeding: Azathioprine crosses the placenta and is excreted in breast milk. Use only if the potential benefit justifies the potential risk, and strictly under specialist supervision. Effective contraception is recommended for both men and women during treatment and for a period after stopping, as advised by the physician.
• Consult your doctor before use if pregnant, nursing, taking other medications, or if you have medical conditions such as liver disease, kidney disease, blood disorders, or a history of cancer.
• Not intended to diagnose, treat, cure, or prevent any disease without medical supervision; it is a prescription-only medicine.
• Keep out of reach of children.
• Do not share this medication with others, even if they have similar symptoms or conditions.

Side Effects:

• Common side effects: Nausea, vomiting, loss of appetite, mild abdominal discomfort, and fatigue. Taking the medicine with food may help reduce stomach upset.
• Hematologic effects: Leukopenia (low white blood cells), anemia, thrombocytopenia (low platelets), which may present as frequent infections, unusual bruising, or bleeding.
• Hepatic effects: Elevated liver enzymes, cholestasis, or liver injury. Symptoms may include yellowing of the skin or eyes, dark urine, or persistent abdominal pain.
• Infections: Increased susceptibility to bacterial, viral, and fungal infections.
• Hypersensitivity reactions: Fever, rash, muscle or joint pain, malaise. Severe reactions may require immediate discontinuation.
• Long-term risks: Increased risk of certain cancers, particularly lymphomas and skin cancers, especially with prolonged use and higher cumulative doses.
• Seek immediate medical attention if you experience high fever, severe sore throat, unusual bleeding or bruising, severe abdominal pain, yellowing of the skin/eyes, severe rash, difficulty breathing, or any other alarming symptoms.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Product type: Prescription immunosuppressant medicine.
• Active ingredient strength: Azathioprine 50 mg per tablet.
• Form: Tablet.
• Pack size: 30 tablets per pack.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.