Bi- Profenid Tablets

Bi- Profenid Tablets

Description:

Bi- Profenid 150 mg Tablets are a prescription-strength oral non-steroidal anti-inflammatory drug (NSAID) containing ketoprofen, indicated for the relief of pain, inflammation, and fever. Manufactured by Sanofi, these scored tablets are designed for adults and are commonly used in the management of rheumatic and musculoskeletal disorders, acute pain, and dysmenorrhea. As an NSAID of the propionic acid derivative class, Bi- Profenid helps reduce prostaglandin synthesis, thereby providing effective analgesic, anti-inflammatory, and antipyretic action.

Indications:

• Rheumatoid arthritis: relief of pain, stiffness, and inflammation in chronic inflammatory joint disease.
• Osteoarthritis: symptomatic treatment of pain and inflammation in degenerative joint disease.
• Acute musculoskeletal disorders: treatment of exacerbations of musculoskeletal, periarticular, and soft tissue conditions (e.g., sprains, strains, tendonitis, bursitis).
• Dysmenorrhea: relief of pain associated with primary dysmenorrhea (menstrual cramps).
• Acute gout attacks: reduction of pain and inflammation in acute gouty arthritis (as part of short-term management).
• Migraine (as per ketoprofen indications): relief of pain in migraine attacks, when recommended by a physician.
• General moderate pain and inflammatory conditions, where an NSAID is indicated and prescribed by a healthcare professional.

Active Ingredients / Key Components:

• Ketoprofen – 150 mg per tablet (propionic acid derivative NSAID, analgesic, antipyretic, anti-inflammatory).
• Excipients: The full list of inactive ingredients (excipients, coloring agents, preservatives, etc.) is not available in the provided information. Please refer to the official package insert for complete excipient details.

Dosage & Administration / How to Use:

• Bi- Profenid Tablets are for oral use only and should be swallowed with a sufficient amount of water.
• Recommended adult dosage (general guidance for ketoprofen 150 mg): usually 150 mg daily, which may be given as a single dose or divided according to physician instructions. Exact dose, frequency, and duration must be determined by the prescribing doctor based on the condition and patient response.
• It is generally recommended to take the tablet with food or after meals to help reduce the risk of gastrointestinal irritation.
• Do not exceed the maximum daily dose prescribed by your doctor. Long-term or high-dose use increases the risk of serious side effects, especially gastrointestinal and cardiovascular events.
• Use in elderly patients, those with renal or hepatic impairment, or patients with a history of gastrointestinal disease requires dose adjustment and close medical supervision.
• Do not crush or chew unless your doctor specifically advises otherwise, even though the tablet is scored to allow dose adjustment.
• If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to make up for a missed dose.
• Always follow your doctor’s instructions and the patient information leaflet provided with the medication.

Clinical Benefits:

• Provides effective analgesic action for moderate pain associated with arthritis, musculoskeletal conditions, and dysmenorrhea.
• Delivers strong anti-inflammatory effects by inhibiting cyclo-oxygenase (COX-1 and COX-2) and reducing prostaglandin synthesis at sites of inflammation.
• Helps reduce fever (antipyretic effect) in inflammatory conditions when indicated.
• Improves mobility and functional capacity in patients with rheumatic and degenerative joint diseases by decreasing pain and swelling.
• Offers convenient 150 mg strength in scored tablet form, allowing flexible dosing as directed by the physician.

Warnings & Contraindications:

• Contraindicated in patients with known hypersensitivity (allergy) to ketoprofen, other NSAIDs (including aspirin), or any component of the formulation.
• Contraindicated in patients with a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
• Contraindicated in active or history of recurrent peptic ulcer/bleeding, gastrointestinal perforation, or severe gastrointestinal disorders related to NSAID use.
• Contraindicated in severe heart failure, severe renal impairment, or severe hepatic impairment unless specifically advised and monitored by a specialist.
• Use with extreme caution in patients with cardiovascular disease, hypertension, hyperlipidemia, diabetes, or in smokers, as NSAIDs may increase the risk of serious cardiovascular thrombotic events (e.g., myocardial infarction, stroke).
• Use with caution in patients with a history of gastrointestinal disease (ulcerative colitis, Crohn’s disease), bleeding disorders, or those taking anticoagulants, antiplatelet agents, or corticosteroids.
• May cause fluid retention and edema; caution in patients with hypertension or heart failure.
• Pregnancy and breastfeeding: Use is generally not recommended, especially in the third trimester of pregnancy, due to risk to the fetus and complications during delivery. Consult your doctor before use if you are pregnant, planning pregnancy, or breastfeeding.
• May cause dizziness, drowsiness, or visual disturbances; if affected, do not drive or operate machinery.
• Avoid concomitant use with other NSAIDs, including selective COX-2 inhibitors, unless specifically directed by your doctor.
• Regular monitoring of renal function, liver function, and blood counts may be required during prolonged therapy.
• Consult your doctor before use if pregnant, nursing, taking medications, or have medical conditions such as kidney disease, liver disease, heart disease, hypertension, gastrointestinal ulcers, bleeding disorders, or asthma.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical supervision.
• Keep out of reach of children.

Side Effects:

• Common side effects: nausea, vomiting, abdominal pain, dyspepsia, heartburn, diarrhea, constipation, flatulence, headache, dizziness, and mild skin rash.
• Less common but serious side effects: gastrointestinal bleeding, ulceration or perforation (may present as black/tarry stools, vomiting blood, severe abdominal pain); severe allergic reactions (angioedema, bronchospasm, anaphylaxis); severe skin reactions (Stevens–Johnson syndrome, toxic epidermal necrolysis); liver function disturbances; kidney function impairment; edema; increased blood pressure.
• Stop taking the medication and seek immediate medical attention if you experience chest pain, shortness of breath, sudden weakness or slurred speech, severe abdominal pain, vomiting blood, black stools, severe skin rash, facial or throat swelling, or difficulty breathing.
• If any side effects persist, worsen, or you notice any unusual symptoms, contact your doctor or pharmacist promptly.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Active ingredient: ketoprofen 150 mg per tablet.
• Form: scored oral tablets.
• Strength: 150 mg.
• Pack size: 20 scored tablets per pack.
• Intended use: prescription NSAID for pain, inflammation, and fever control in adults, as directed by a healthcare professional.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.