Colchicine 500 Microgram 100 Tablets

Colchicine 500 Microgram 100 Tablets

Description:

Colchicine 500 microgram 100 tablets is a prescription oral medicine used primarily for the treatment and prevention of gout attacks and certain inflammatory conditions. Each tablet contains 500 microgram of colchicine, an anti-inflammatory agent that works by inhibiting microtubule polymerization and reducing the activity of inflammatory cells. This targeted action helps decrease lactic acid production by leukocytes, reduce uric acid crystal deposition, and attenuate the inflammatory response in gout and related disorders. Manufactured by El Nasr, this product is intended for adult use under medical supervision and is commonly used in chronic management and acute flare control of gout and other colchicine-responsive conditions.

Indications:

• Acute gout attacks (gout flares) to reduce pain, swelling, and inflammation.
• Gouty arthritis for prevention of recurrent gout attacks as part of long-term management.
• Calcium pyrophosphate deposition disease (pseudogout) to relieve joint inflammation and pain.
• Familial Mediterranean fever (FMF) to prevent inflammatory attacks and complications such as amyloidosis.
• Amyloidosis (certain types) as part of the therapeutic regimen as directed by a specialist.
• Behcet's syndrome to help control inflammatory manifestations as prescribed by a physician.
• Sarcoid arthritis and other selected inflammatory arthritides when recommended by a rheumatologist.
• Pericarditis (including recurrent pericarditis) as adjunct therapy to reduce inflammation and recurrence risk.
• Cirrhosis-related inflammatory conditions where colchicine is specifically indicated by a specialist.
• Used as an immunosuppressive/anti-inflammatory agent in specific conditions under specialist guidance.

Active Ingredients / Key Components:

• Colchicine – 500 microgram per tablet.
• Excipients: Information on other inactive ingredients (such as fillers, binders, coloring agents, or preservatives) is not available in the provided data. Please refer to the package leaflet for the full excipient list.

Dosage & Administration / How to Use:

• Use only as prescribed by a physician. Dosage varies according to indication, age, kidney and liver function, and concomitant medications.
• Acute gout attack (typical adult regimen – may vary by guideline and physician): Often initiated at the first sign of a flare. A common regimen is a loading dose followed by smaller doses until symptom relief or maximum dose is reached. Exact dosing must be determined by the treating doctor to minimize toxicity.
• Gout prophylaxis: Usually a lower daily dose taken once or twice daily to prevent recurrent attacks, often in combination with urate-lowering therapy. Follow your doctor’s exact instructions.
• Familial Mediterranean fever and other chronic indications: Taken regularly every day at a dose individualized by the specialist to control disease activity while minimizing side effects.
• Tablets are taken orally with a glass of water, with or without food. Taking with food may help reduce gastrointestinal discomfort.
• Do not exceed the prescribed daily dose. Colchicine has a narrow therapeutic index and overdose can be serious or fatal.
• If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to make up for a missed dose.
• In patients with kidney or liver impairment, or in elderly patients, lower doses and/or extended dosing intervals are usually required. Strictly follow medical advice.
• Avoid concomitant use with certain medicines (e.g., strong CYP3A4 inhibitors or P-glycoprotein inhibitors) unless your doctor has adjusted the dose and is closely monitoring you.

Clinical Benefits:

• Rapidly reduces pain, redness, and swelling associated with acute gout attacks when taken early in the flare.
• Helps prevent recurrent gout flares and gouty arthritis when used as long-term prophylaxis as directed by a physician.
• Controls inflammatory attacks in familial Mediterranean fever and reduces the risk of secondary amyloidosis.
• Provides anti-inflammatory and immunomodulatory effects in selected conditions such as pseudogout, Behcet’s syndrome, pericarditis, and certain inflammatory arthritides.

Warnings & Contraindications:

• Colchicine is a potent prescription medicine with a narrow safety margin. Use only under medical supervision and never exceed the prescribed dose.
• Contraindicated in patients with severe renal or hepatic impairment unless specifically adjusted and supervised by a specialist.
• Contraindicated in patients with known hypersensitivity to colchicine or any component of the formulation.
• Use with extreme caution in elderly patients, debilitated patients, or those with gastrointestinal, cardiac, renal, or hepatic disease.
• Serious and potentially fatal toxicity may occur, especially with overdose or in combination with strong CYP3A4 or P-glycoprotein inhibitors (such as certain macrolide antibiotics, azole antifungals, some antivirals). Inform your doctor about all medications you are taking.
• May cause bone marrow suppression, leading to low white blood cells, anemia, or low platelets. Periodic blood tests may be required in long-term use.
• Consult your doctor before use if pregnant or planning pregnancy. Colchicine should be used in pregnancy only if clearly needed and prescribed by a specialist.
• Consult your doctor before use if breastfeeding. Colchicine passes into breast milk; your doctor will weigh benefits and risks.
• Inform your doctor if you have kidney disease, liver disease, blood disorders, gastrointestinal disease, or if you consume large amounts of alcohol.
• Not intended for self-treatment of joint pain without a confirmed diagnosis of gout or other colchicine-responsive condition.
• Keep out of reach of children.
• Not intended to diagnose, treat, cure, or prevent any disease without medical supervision and prescription.

Side Effects:

• Common side effects: Nausea, vomiting, abdominal pain, diarrhea, and loss of appetite. Gastrointestinal symptoms are dose-related and may improve with dose reduction as advised by your doctor.
• Less common side effects: Fatigue, headache, hair loss (alopecia), muscle pain or weakness, numbness or tingling, and skin rash.
• Serious side effects (seek immediate medical attention): Severe or persistent vomiting or diarrhea, signs of dehydration, unusual bleeding or bruising, signs of infection (fever, sore throat), severe muscle pain or weakness, dark urine, yellowing of the skin or eyes (jaundice), extreme fatigue, or difficulty breathing.
• Stop taking the medicine and contact your doctor or go to the nearest emergency department if you suspect overdose or experience severe or rapidly worsening symptoms.

Storage Instructions:

Store in a cool, dry place away from direct sunlight and moisture. Keep the container tightly closed and store at or below the temperature specified on the package (typically below 25°c, if indicated on the pack). Do not use after the expiry date printed on the packaging. Keep out of reach of children.

Specifications:

• Product type: Prescription oral medicine for gout and inflammatory conditions.
• Strength: 500 microgram colchicine per tablet.
• Form: Tablet.
• Pack size: 100 tablets per pack.
• Intended users: Adults and adolescents as prescribed by a healthcare professional.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.