Special Import - Colchicine Opocalcium 1Mg 20 Comprimés

Colchicine Opocalcium 1 Mg 20 Tablets

Description:

Colchicine Opocalcium 1 mg 20 tablets is a prescription oral medicine used primarily for the treatment and prevention of gout attacks and certain inflammatory conditions. Each tablet contains colchicine, a well-known anti-inflammatory agent that works by inhibiting microtubule polymerization in inflammatory cells, thereby reducing lactic acid production, uric acid crystal deposition, and the inflammatory response in joints. It is commonly used under medical supervision for gouty arthritis, familial Mediterranean fever, and other colchicine-responsive inflammatory diseases. This product is intended for adult use and must be taken exactly as directed by a healthcare professional.

Indications:

• Treatment of acute gout attacks (acute gouty arthritis), helping relieve pain, redness, and swelling in affected joints.
• Prevention of recurrent gout flares in patients with chronic gout when used as part of a long-term management plan.
• Management of familial Mediterranean fever (FMF) to reduce the frequency and intensity of inflammatory attacks (per physician guidance).
• Adjunct treatment in certain inflammatory conditions such as Behçet's syndrome, pericarditis, sarcoid arthritis, amyloidosis, and calcium pyrophosphate deposition disease (pseudogout), only when specifically prescribed by a specialist.
• Use as an immunomodulatory/anti-inflammatory agent in selected conditions where colchicine is indicated by clinical guidelines and physician judgment.

Active Ingredients / Key Components:

• Colchicine – 1 mg per tablet.
• Excipients: Other inactive ingredients (tablet core and coating excipients) are present but not specified in the available product information.

Dosage & Administration / How to Use:

• Always use exactly as prescribed by your doctor. Do not exceed the recommended dose due to the narrow therapeutic index and risk of toxicity.
• For acute gout attack (typical adult dosing – may vary by guideline and physician):
  • An initial dose is usually given at the first sign of a flare, followed by smaller doses as directed by the physician. Your doctor will determine the exact regimen and maximum total dose per attack.
  • Treatment should be started as soon as possible after symptom onset.
• For prevention of gout attacks / chronic gout:
  • A lower maintenance dose is usually prescribed once or twice daily to prevent recurrent flares. The exact dose and duration are individualized by the treating physician.
• For familial Mediterranean fever and other indications:
  • Dose, frequency, and duration are strictly individualized based on age, weight, kidney and liver function, and clinical response.
• Swallow the tablet whole with a full glass of water. It can be taken with or without food. Taking with food may help reduce gastrointestinal discomfort.
• If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to make up for a missed one.
• In elderly patients or those with kidney or liver impairment, lower doses and longer intervals between doses are usually required. Strict medical supervision is essential.

Clinical Benefits:

• Rapidly reduces inflammation in acute gout attacks, helping relieve joint pain, swelling, and redness.
• Decreases lactic acid production by leukocytes and reduces uric acid crystal deposition, contributing to better long-term gout control when used as prescribed.
• Helps prevent recurrent gout flares when used as part of a comprehensive uric acid–lowering treatment plan.
• Provides proven anti-inflammatory and immunomodulatory effects in familial Mediterranean fever and other colchicine-responsive inflammatory conditions.

Warnings & Contraindications:

• Colchicine has a narrow therapeutic index; overdose can be life-threatening. Never exceed the prescribed dose.
• Contraindicated in patients with severe renal impairment or severe hepatic impairment unless specifically adjusted and monitored by a specialist.
• Contraindicated in patients with known hypersensitivity to colchicine or any component of the formulation.
• Use with extreme caution in elderly patients and those with mild to moderate kidney or liver disease; dose adjustment and close monitoring are required.
• Concomitant use with strong CYP3A4 inhibitors (such as certain macrolide antibiotics, some antifungals, and some HIV protease inhibitors) or P-glycoprotein inhibitors can significantly increase colchicine levels and risk of toxicity; such combinations may be contraindicated or require strict medical supervision.
• Consult your doctor before use if pregnant or planning pregnancy. Colchicine should only be used in pregnancy if the potential benefit justifies the potential risk. Discuss contraception if of childbearing potential.
• Consult your doctor before use if breastfeeding; colchicine may pass into breast milk. Your doctor will weigh the benefits and risks.
• Inform your doctor if you have blood disorders, gastrointestinal disease, heart disease, or are taking other medications such as statins, fibrates, immunosuppressants, or other gout medicines.
• Not intended for self-medication or casual use. This medicine must be used under medical supervision.
• Keep out of reach of children.

Side Effects:

• Common side effects: Nausea, vomiting, abdominal pain, diarrhea, and loss of appetite. Gastrointestinal symptoms are dose-related and may indicate that the dose is too high.
• Less common side effects: Fatigue, headache, muscle pain or weakness, numbness or tingling, rash, or hair loss.
• Serious side effects (seek immediate medical attention): Severe or persistent vomiting or diarrhea, signs of dehydration, severe muscle pain or weakness (possible myopathy or rhabdomyolysis), unusual bruising or bleeding, signs of infection (fever, sore throat), pale skin or extreme tiredness (possible blood disorders), or any symptoms suggestive of overdose (burning throat, severe abdominal pain, multi-organ symptoms).
• If you experience any unexpected or severe side effects, stop taking the medicine and contact your doctor or seek emergency care immediately.

Storage Instructions:

Store in a cool, dry place away from direct sunlight and moisture. Keep the blister pack or container tightly closed. Do not store above 30°c unless otherwise stated on the pack. Keep out of reach of children. Do not use after the expiry date printed on the packaging.

Specifications:

• Product form: Tablets for oral use.
• Strength: 1 mg colchicine per tablet.
• Pack size: 20 tablets per pack.
• Intended use: Prescription medicine for gout and other colchicine-indicated inflammatory conditions in adults, under medical supervision.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.