Crestor 20Mg 28Tab

Crestor 20Mg 28Tab

Description:

Crestor 20 mg film-coated tablets are a prescription lipid-lowering medicine containing rosuvastatin, a statin (HMG‑CoA reductase inhibitor) used to reduce high cholesterol and triglycerides and to help protect against cardiovascular disease. Manufactured by AstraZeneca, Crestor is indicated for adults and certain adolescents with hypercholesterolemia or mixed dyslipidemia to lower low-density lipoprotein (LDL) cholesterol, non-HDL cholesterol, total cholesterol, and triglycerides, while modestly increasing high-density lipoprotein (HDL) cholesterol. It is used as part of a comprehensive cardiovascular risk reduction plan that includes diet, exercise, and lifestyle modification.

Indications:

• Treatment of primary hypercholesterolemia (heterozygous familial and non-familial) and mixed dyslipidemia as an adjunct to diet.
• Treatment of homozygous familial hypercholesterolemia as an adjunct to diet and other lipid-lowering treatments (such as LDL apheresis) or when such treatments are not appropriate.
• Reduction of elevated LDL cholesterol, total cholesterol, non-HDL cholesterol, apolipoprotein B, and triglycerides.
• Increase in HDL cholesterol and improvement of overall lipid profile in patients with dyslipidemia.
• Prevention of major cardiovascular events (such as myocardial infarction, stroke, or arterial revascularization) in patients at high risk for a first cardiovascular event, as part of a comprehensive risk reduction strategy.
• Management of patients with multiple cardiovascular risk factors (e.g., hypertension, low HDL, smoking, family history of premature coronary heart disease, or elevated C-reactive protein) where statin therapy is indicated.

Active Ingredients / Key Components:

• Rosuvastatin calcium – equivalent to 20 mg rosuvastatin per film-coated tablet.
• Excipients (inactive ingredients) may include lactose monohydrate, microcrystalline cellulose, calcium phosphate, crospovidone, magnesium stearate, and film-coating agents; exact excipient list and concentrations are not available here and should be confirmed from the package leaflet.

Dosage & Administration / How to Use:

• Use Crestor 20 mg only under medical supervision and according to your doctor’s prescription.
• Usual starting dose in adults is often 5 mg or 10 mg once daily, adjusted based on lipid levels and cardiovascular risk. The 20 mg strength is typically used when lower doses are insufficient or when higher-intensity statin therapy is required. Do not initiate or change to 20 mg without medical advice.
• Recommended dose range in adults is generally 5–40 mg once daily. The 40 mg dose is reserved for severe hypercholesterolemia and high-risk patients and requires close monitoring.
• Take one tablet once daily, at the same time each day, with or without food. Swallow the tablet whole with a glass of water; do not crush or chew.
• Continue to follow a cholesterol-lowering diet and lifestyle (low saturated fat diet, regular physical activity, weight management, smoking cessation) during treatment.
• If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not take a double dose to make up for a missed tablet.
• Dosage adjustments may be required in patients with kidney impairment, liver impairment, Asian ethnicity, or those taking interacting medicines. Always follow your doctor’s instructions regarding dose.
• Not recommended in children unless specifically prescribed by a pediatric specialist according to approved indications and dosing guidelines.

Clinical Benefits:

• Potent LDL cholesterol reduction: Helps significantly lower “bad” LDL cholesterol, a key factor in atherosclerosis and cardiovascular disease.
• Improves overall lipid profile: Reduces total cholesterol, non-HDL cholesterol, apolipoprotein B, and triglycerides while modestly increasing “good” HDL cholesterol.
• Cardiovascular risk reduction: When used long term as prescribed, Crestor helps reduce the risk of heart attack, stroke, and the need for coronary revascularization in high-risk patients.
• Slows progression of atherosclerosis: By lowering LDL and non-HDL cholesterol, rosuvastatin helps slow plaque buildup in arteries and supports better vascular health.
• Once-daily dosing: Convenient once-daily tablet supports adherence to long-term lipid-lowering therapy.

Warnings & Contraindications:

• Contraindicated in patients with active liver disease, including unexplained persistent elevations of serum transaminases.
• Contraindicated in patients with severe renal impairment (unless specifically adjusted and supervised by a specialist), and in those with a history of serious muscle disorders related to statin use (e.g., myopathy, rhabdomyolysis).
• Contraindicated during pregnancy and breastfeeding. Women of childbearing potential should use effective contraception during treatment.
• Use with caution in patients with risk factors for myopathy/rhabdomyolysis, such as age >65 years, hypothyroidism, personal or family history of hereditary muscle disorders, previous muscle toxicity with statins or fibrates, excessive alcohol intake, or concomitant use of drugs that increase rosuvastatin levels.
• Periodic monitoring of liver function tests and creatine kinase (CK) may be recommended, especially after dose increases or if symptoms occur.
• Stop treatment and seek medical advice immediately if you develop unexplained muscle pain, tenderness, weakness, or cramps, especially if accompanied by malaise or fever.
• Use with caution in patients with moderate renal impairment, hypothyroidism, or a history of liver disease, and in those of Asian origin, as lower starting doses may be required.
• Potential interactions with cyclosporine, certain protease inhibitors, some fibrates (e.g., gemfibrozil), niacin at lipid-lowering doses, and other medicines that affect statin metabolism. Inform your doctor about all medicines and supplements you are taking.
• Alcohol: Excessive alcohol consumption may increase the risk of liver side effects; limit alcohol intake during therapy.
• Consult your doctor before use if pregnant, nursing, taking medications, or have medical conditions such as liver disease, kidney disease, thyroid disorders, diabetes, or muscle disorders.
• Not intended for use without medical supervision. This prescription medicine must be used strictly according to your doctor’s directions.
• Keep out of reach of children.

Side Effects:

• Common side effects may include headache, dizziness, abdominal pain, constipation, nausea, muscle pain (myalgia), and weakness. These are usually mild and transient.
• Less common side effects can include itching or rash, joint pain, and elevated liver enzymes on blood tests.
• Serious but rare side effects include myopathy, rhabdomyolysis (severe muscle breakdown that can lead to kidney damage), severe muscle pain or weakness, dark-colored urine, and significant liver injury (e.g., jaundice, marked fatigue, dark urine, upper right abdominal pain).
• Rosuvastatin may slightly increase blood sugar levels and in some patients can unmask or worsen diabetes; regular monitoring may be advised in at-risk individuals.
• Seek immediate medical attention if you experience severe muscle pain, unexplained muscle weakness, difficulty breathing, swelling of the face or tongue, severe abdominal pain, yellowing of the skin or eyes, or any signs of an allergic reaction.

Storage Instructions:

Store in a cool, dry place away from direct sunlight and moisture. Keep the blister pack in the outer carton to protect from light. Do not store above the temperature specified on the package (typically below 25–30°c; check local pack instructions). Keep container tightly closed and out of reach of children. Do not use after the expiry date printed on the pack.

Specifications:

• Product type: Prescription lipid-lowering medicine (statin).
• Strength: 20 mg rosuvastatin per film-coated tablet.
• Form: Film-coated tablet.
• Pack size: 28 tablets per pack.
• Route of administration: Oral.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.