Depakine 5.764/100Ml Syrup 125Mll

Depakine 5.764 gm Syrup 125 ml

Description:

Depakine 5.764 gm Syrup 125 ml is a prescription anti-epileptic medicine containing valproic acid, designed to help control seizures and stabilize mood. It is commonly used in the management of epilepsy, certain types of seizures in children and adults, and as part of the treatment of bipolar disorder and migraine prophylaxis, under medical supervision. This oral syrup form is particularly suitable for patients who have difficulty swallowing tablets, including children, allowing accurate dose adjustment based on body weight.

Indications:

• Treatment of various types of epilepsy and seizures (generalized seizures, partial seizures, absence seizures) in adults and children, as prescribed by a neurologist.
• Adjunctive therapy in patients with refractory epilepsy when other anti-epileptic drugs are insufficient, according to physician recommendation.
• Management of acute manic episodes associated with bipolar disorder (as part of a comprehensive treatment plan, when prescribed by a psychiatrist).
• Prophylaxis of migraine headaches in adults when other treatments are unsuitable or ineffective (only under specialist supervision).
• Helps reduce seizure frequency and intensity and supports long-term seizure control when taken regularly as directed.

Active Ingredients / Key Components:

• Valproic acid (as sodium valproate equivalent) – 57.64 mg/ml oral syrup (total 5.764 g valproic acid in 125 ml bottle).
• Excipients: Full list of inactive ingredients (such as solvents, sweeteners, flavoring agents, stabilizers, and preservatives) is not available in the provided data. Please refer to the official package leaflet for complete excipient information.

Dosage & Administration / How to Use:

• Depakine syrup must be used exactly as prescribed by your doctor. Dosage is individualized based on age, body weight, type of seizures, and response to treatment.
• General dosing (epilepsy – typical guidance, always follow your doctor’s instructions): Initial doses are usually low and gradually increased. Pediatric doses are commonly calculated in mg/kg/day, divided into 2–3 doses. Adults may receive a total daily dose divided into 2–3 administrations.
• Measure the dose carefully using the supplied measuring device or an accurate oral syringe/spoon to ensure correct ml amount.
• Depakine syrup can usually be taken with or after food to help reduce gastrointestinal discomfort, unless your doctor advises otherwise.
• Take the doses at the same times each day to maintain stable blood levels and optimal seizure control.
• Do not stop taking Depakine suddenly without medical advice, as abrupt discontinuation may increase seizure risk or trigger status epilepticus.
• If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to make up for a missed one.
• This medicine is for oral use only. Do not inject or mix with other liquid medicines unless instructed by your doctor or pharmacist.

Clinical Benefits:

• Helps control and reduce the frequency and severity of epileptic seizures when used regularly under medical supervision.
• Stabilizes neuronal activity by modulating sodium and calcium channels and enhancing gamma-aminobutyric acid (gaba), an inhibitory neurotransmitter in the brain.
• Supports mood stabilization in patients with bipolar disorder during acute manic episodes as part of a comprehensive treatment plan.
• Provides effective migraine prophylaxis in selected patients, helping decrease the number and intensity of migraine attacks.
• Liquid syrup form allows flexible, precise dosing, especially useful for children or adults who cannot swallow tablets.

Warnings & Contraindications:

• Contraindicated in patients with known hypersensitivity to valproic acid, sodium valproate, or any component of the formulation.
• Contraindicated in patients with active liver disease, significant hepatic dysfunction, or a history of severe liver injury associated with valproate use.
• Contraindicated in patients with known urea cycle disorders, certain mitochondrial disorders (e.g., POLG-related disorders), or severe pancreatitis.
• Use with extreme caution in children under 3 years, especially when combined with other anti-epileptic drugs or in those with metabolic, genetic, or structural brain disorders.
• Valproic acid can cause serious liver toxicity, especially during the first 6 months of treatment. Regular liver function monitoring is required as advised by your doctor.
• May cause pancreatitis, which can be life-threatening. Seek immediate medical attention if you develop severe abdominal pain, nausea, or vomiting.
• May increase the risk of birth defects and developmental disorders if taken during pregnancy. Women of childbearing potential must use effective contraception and discuss pregnancy planning with their doctor.
• Consult your doctor before use if pregnant, planning pregnancy, nursing, taking other medications (especially other anti-epileptics, anticoagulants, aspirin, or psychotropic drugs), or if you have liver disease, kidney disease, metabolic disorders, or a history of pancreatitis.
• May cause drowsiness, dizziness, or blurred vision. Avoid driving or operating machinery until you know how the medicine affects you.
• Alcohol consumption should be limited or avoided, as it may increase central nervous system side effects and seizure risk.
• Keep out of reach of children.
• Not intended to diagnose, treat, cure, or prevent any disease without medical supervision. Use only under the guidance of a qualified healthcare professional.

Side Effects:

• Common side effects: Nausea, vomiting, stomach pain, indigestion, diarrhea, increased appetite or weight gain, tremor, drowsiness, dizziness, headache, hair thinning or temporary hair loss, and changes in menstrual cycle.
• Less common or serious side effects: Liver function abnormalities, jaundice (yellowing of skin or eyes), severe abdominal pain (possible pancreatitis), unusual bruising or bleeding, severe fatigue, confusion, behavior changes, depression, suicidal thoughts, or allergic reactions such as rash, itching, swelling, or difficulty breathing.
• Seek immediate medical attention if you notice signs of liver problems (loss of appetite, vomiting, tiredness, dark urine, yellowing of skin/eyes), severe abdominal pain, severe rash, swelling of face or throat, or any sudden change in seizure pattern.
• Report any persistent or bothersome side effects to your doctor or pharmacist. Do not stop the medicine without medical advice.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children. Do not use after the expiry date shown on the pack. Do not freeze. Store at the temperature range recommended in the official leaflet (information not provided here; refer to pack for exact storage conditions).

Specifications:

• Product type: Oral anti-epileptic medicine (valproic acid) syrup.
• Strength: 57.64 mg/ml valproic acid (total 5.764 g per 125 ml bottle).
• Form: Syrup for oral use.
• Pack size: 125 ml bottle.
• Intended users: Adults and children as prescribed by a healthcare professional.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.