Diavance 5 Glyburide 5Mg Metformin Hci 500Mg 30Tab

Diavance 5 Mg 30 Tablets

Description:

Diavance 5 mg 30 tablets is an oral anti-diabetic prescription medicine used for the management of type 2 diabetes mellitus. The product referred to in the note is DIAVANCE 5/500 mg 30 film-coated tablets, which contains a fixed-dose combination of glibenclamide (glyburide) and metformin, manufactured by Sigma. It helps control high blood sugar in adults with type 2 diabetes when diet and exercise alone are not sufficient, and is typically used as part of a comprehensive diabetes care plan including lifestyle modification and regular blood glucose monitoring.

Indications:

• Management of type 2 diabetes mellitus (non–insulin-dependent diabetes mellitus) in adults.
• Used when blood glucose levels are inadequately controlled by diet, exercise, and metformin or sulfonylurea monotherapy.
• Helps reduce elevated fasting and postprandial (after-meal) blood glucose levels.
• May help reduce the risk of diabetes-related complications when used as part of long-term glycemic control under medical supervision.

Active Ingredients / Key Components:

• Glibenclamide (Glyburide) – 5 mg per tablet (sulfonylurea class oral hypoglycemic agent).
• Metformin – 500 mg per tablet (biguanide class oral anti-diabetic agent).
• Other excipients: film-coating agents and tablet core excipients (full excipient list is not available in the provided information; please refer to the printed package insert for complete details).

Dosage & Administration / How to Use:

• Diavance 5/500 mg is a prescription medicine; dosage must always be individualized and determined by a physician based on blood glucose levels, clinical response, and tolerance.
• Typical adult dosing: usually 1 tablet once or twice daily, taken with meals to reduce gastrointestinal side effects and the risk of hypoglycemia. The exact dose and frequency are set by the treating doctor.
• Swallow the tablet whole with a glass of water; do not crush or chew unless your doctor or pharmacist specifically advises otherwise.
• Take the medicine at the same time(s) each day, preferably with breakfast and/or the main meal, to maintain consistent blood levels and better glycemic control.
• Do not skip meals while taking this medication, as this increases the risk of low blood sugar (hypoglycemia).
• If a dose is missed, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to make up for a missed one.
• Regular monitoring of blood glucose (and sometimes HbA1c) is recommended to assess treatment effectiveness and guide dose adjustments.
• Use in elderly patients, those with renal or hepatic impairment, or those at risk of lactic acidosis requires special caution and strict medical supervision.

Clinical Benefits:

• Provides dual mechanism of action: glibenclamide increases insulin secretion from pancreatic beta cells, while metformin reduces hepatic glucose production and improves peripheral insulin sensitivity.
• Helps achieve better overall glycemic control in type 2 diabetes compared with monotherapy in suitable patients.
• Metformin component may contribute to improved lipid profile and weight neutrality or modest weight reduction in many patients.
• May help reduce the risk of long-term microvascular and macrovascular complications of diabetes (such as neuropathy, nephropathy, and retinopathy) when used as part of comprehensive diabetes management.

Warnings & Contraindications:

• Contraindicated in patients with known hypersensitivity to glibenclamide, metformin, other sulfonylureas, sulfonamides, or any component of the formulation.
• Contraindicated in type 1 diabetes mellitus, diabetic ketoacidosis, diabetic pre-coma or coma.
• Contraindicated in severe renal impairment or significant renal dysfunction due to increased risk of metformin-associated lactic acidosis. Renal function must be assessed before starting and periodically during treatment.
• Use with caution in hepatic impairment, heart failure, dehydration, severe infection, shock, or conditions associated with hypoxia, as these increase the risk of lactic acidosis.
• Glibenclamide can cause hypoglycemia, sometimes severe; risk is higher in elderly, malnourished patients, those with irregular meals, strenuous exercise, or concomitant use of other hypoglycemic agents or alcohol.
• Alcohol intake should be limited or avoided, as it may potentiate the effect of metformin on lactate metabolism and increase the risk of lactic acidosis and hypoglycemia.
• Temporarily discontinue metformin-containing products before iodinated contrast imaging procedures and in situations of acute illness, dehydration, or surgery, as directed by a physician.
• Consult your doctor before use if pregnant, planning pregnancy, or breastfeeding; insulin may be preferred during pregnancy and lactation.
• Consult your doctor before use if you have kidney disease, liver disease, heart failure, respiratory disease, alcohol abuse, endocrine disorders (e.g., adrenal or pituitary insufficiency), or are taking other medications that may affect blood glucose.
• May cause dizziness or blurred vision due to hypoglycemia; use caution when driving or operating machinery until you know how the medicine affects you.
• Keep out of reach of children.

Side Effects:

• Common side effects (usually related to metformin): gastrointestinal disturbances such as nausea, vomiting, abdominal discomfort, diarrhea, metallic taste, and loss of appetite, especially at the start of therapy; these often improve with continued use and taking the tablets with meals.
• Hypoglycemia (low blood sugar) due to glibenclamide: symptoms include sweating, tremor, hunger, palpitations, headache, dizziness, blurred vision, confusion, and in severe cases loss of consciousness or seizures. Immediate intake of fast-acting carbohydrates (e.g., glucose tablets, sugary drink) and medical attention may be required.
• Rare but serious: lactic acidosis associated with metformin, a medical emergency characterized by rapid breathing, muscle pain, abdominal pain, severe fatigue, feeling cold, dizziness, or slow/irregular heartbeat. Stop the medicine and seek urgent medical care if these occur.
• Other possible effects: skin reactions (rash, pruritus, urticaria), liver enzyme changes, or hematologic changes (e.g., rare blood dyscrasias). Report any unusual or persistent symptoms to your doctor.
• Seek immediate medical attention if you experience severe hypoglycemia, signs of lactic acidosis, allergic reactions (swelling of face, lips, tongue, or throat; difficulty breathing), or severe abdominal pain.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Form: film-coated tablet.
• Strength: glibenclamide 5 mg + metformin 500 mg per tablet (fixed-dose combination) – based on the referenced DIAVANCE 5/500 mg product.
• Pack size: 30 tablets per pack.
• Route of administration: oral.
• Intended use: prescription medicine for adults with type 2 diabetes mellitus.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.