Domperidone Tablets

Domperidone Tablets

Description:

Domperidone Tablets 10 mg by SEDICO are prescription oral antiemetic and gastrointestinal motility stimulant medicines used to relieve nausea, vomiting, and symptoms related to delayed gastric emptying. Domperidone is a dopamine (D2) receptor antagonist that acts both centrally on the chemoreceptor trigger zone and peripherally on the gastrointestinal tract to improve gastric motility and facilitate gastric emptying. These tablets are commonly used in conditions such as nausea and vomiting associated with gastrointestinal disorders, migraine, and as an adjunct in patients receiving cytotoxic drugs or pre-anaesthetic medication. Always use under medical supervision.

Indications:

• Relief of nausea and vomiting of various causes, especially those associated with gastrointestinal disorders.
• Nausea and vomiting associated with migraine attacks (often used with analgesics for migraine management).
• Delayed gastric emptying of functional origin (functional dyspepsia), including symptoms such as early satiety, bloating, and upper abdominal discomfort related to slow gastric emptying.
• As an antiemetic in patients receiving cytotoxic (chemotherapy) drugs, as directed by a physician.
• Pre-anaesthetic and post-operative use to reduce the risk of nausea and vomiting, according to anaesthetist or surgeon instructions.

Active Ingredients / Key Components:

• Domperidone – 10 mg per tablet.
• Inactive ingredients (excipients): Exact excipient list and concentrations , please check the product leaflet or the manufacturer’s official website. Refer to the package leaflet for full details.

Dosage & Administration / How to Use:

• Use only as prescribed by your doctor or as directed by a pharmacist.
• Adults and adolescents (as directed by physician): Commonly 10 mg (1 tablet) taken up to 3 times daily before meals. Maximum daily dose and duration must be determined by the doctor.
• Take tablets preferably 15–30 minutes before meals to optimize effect on gastric motility.
• Swallow the tablet whole with a glass of water; do not crush or chew unless your doctor advises otherwise.
• Do not exceed the prescribed dose or duration of treatment, especially in elderly patients or those with underlying heart conditions.
• Patients with kidney impairment may require dose adjustment or less frequent dosing; follow medical advice.
• If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to make up for a missed one.
• Not recommended for use in children without explicit medical supervision; dosing in paediatric patients must be strictly according to a doctor’s instructions.

Clinical Benefits:

• Helps control and relieve nausea and vomiting from various causes, improving overall comfort and daily functioning.
• Enhances gastric motility and accelerates gastric emptying, which may reduce bloating, fullness, and upper abdominal discomfort.
• Increases oesophageal peristalsis and sphincter pressure, which may help reduce reflux-related symptoms as directed by a physician.
• Provides antiemetic support in patients receiving cytotoxic chemotherapy or undergoing anaesthesia, helping reduce treatment-related nausea and vomiting.

Warnings & Contraindications:

• Use only under medical supervision. Do not use this medicine without a doctor’s prescription and regular follow-up.
• Contraindicated in patients with known hypersensitivity to domperidone or any of the tablet components.
• Contraindicated in patients with prolactin-releasing pituitary tumour (prolactinoma).
• Do not use in patients with gastrointestinal bleeding, mechanical obstruction, or perforation, where increased gastrointestinal motility could be harmful.
• Use with caution in patients with liver impairment; dose adjustment or alternative therapy may be required.
• Domperidone has been associated with QT interval prolongation and serious ventricular arrhythmias, especially at higher doses or in patients with underlying cardiac disease. Use cautiously in patients with heart disease, electrolyte disturbances, or those taking other QT-prolonging drugs.
• Avoid concomitant use with potent CYP3A4 inhibitors (such as certain antifungals, macrolide antibiotics, and some antivirals) unless specifically advised by your doctor.
• Consult your doctor before use if pregnant or planning pregnancy. Domperidone should only be used in pregnancy if the potential benefit justifies the potential risk.
• If breastfeeding, consult your doctor before use, as domperidone may pass into breast milk in small amounts.
• Consult your doctor before use if you have liver disease, kidney disease, heart disease, arrhythmias, electrolyte imbalance, or are taking other medications.
• May cause drowsiness or dizziness in some patients; if affected, avoid driving or operating machinery.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical supervision.
• Keep out of reach of children.

Side Effects:

• Common side effects may include dry mouth, headache, abdominal cramps, diarrhoea, or constipation.
• Endocrine-related effects such as increased prolactin levels may occur, potentially causing breast tenderness, galactorrhoea (milk secretion), or menstrual irregularities.
• Rare but serious side effects include allergic reactions (rash, itching, swelling of face or throat, severe dizziness, difficulty breathing) and cardiac effects such as palpitations, arrhythmias, or fainting.
• Stop using the medicine and seek immediate medical attention if you experience chest pain, severe dizziness, fainting, irregular heartbeat, or signs of severe allergy.
• If any side effects persist or worsen, contact your doctor or pharmacist promptly.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Strength: 10 mg domperidone per tablet.
• Form: Oral tablets.
• Pack size: 20 tablets per pack (20 tab).
• Intended use: Prescription antiemetic and gastrointestinal motility stimulant for adults and adolescents as directed by a healthcare professional.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.