Gliptus Plus 50/1000 Mg

Gliptus Plus 50/1000 Mg

Description:

Gliptus Plus 50/1000 mg is an oral anti-diabetic prescription medicine used for the management of type 2 diabetes mellitus in adults. It combines two active ingredients, vildagliptin and metformin hydrochloride, to help control high blood glucose levels when diet, exercise, and/or metformin alone are not sufficient. Gliptus Plus belongs to the class of DPP-4 inhibitors (vildagliptin) and biguanides (metformin), offering dual and complementary mechanisms of action to improve glycemic control and reduce the risk of diabetes-related complications such as cardiovascular disease, kidney damage, and neuropathy.

Indications:

• Type 2 diabetes mellitus in adults, particularly in patients insufficiently controlled on metformin alone.
• Type 2 diabetes mellitus in adults already treated with the combination of vildagliptin and metformin as separate tablets, to simplify therapy into a single tablet.
• Helps reduce elevated fasting and postprandial (after-meal) blood glucose levels.
• Used as an adjunct to diet and exercise to improve glycemic control and help prevent long-term complications of diabetes such as cardiovascular events, nephropathy, retinopathy, and neuropathy.

Active Ingredients / Key Components:

• Vildagliptin – 50 mg per tablet
• Metformin hydrochloride – 1000 mg per tablet
• Other inactive ingredients (excipients) are present but detailed composition is not available in the provided information.

Dosage & Administration / How to Use:

• Gliptus Plus 50/1000 mg is for oral use only and must be taken exactly as prescribed by your physician.
• Usual adult dose: commonly 1 tablet twice daily (morning and evening), or as directed by the treating doctor, depending on previous therapy and blood glucose control. The exact dose regimen must be individualized.
• Take the tablet with meals to reduce the risk of gastrointestinal side effects related to metformin (such as nausea and abdominal discomfort).
• Swallow the tablet whole with a glass of water; do not crush or chew unless your doctor or pharmacist specifically advises otherwise.
• If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not double the dose to make up for a missed dose.
• Regular monitoring of blood glucose, HbA1c, and kidney function is recommended during treatment.
• Do not stop taking this medication without consulting your doctor, even if you feel well, as diabetes is a chronic condition.

Clinical Benefits:

• Provides dual mechanism of action: vildagliptin enhances incretin hormones to increase insulin secretion and decrease glucagon release, while metformin reduces hepatic glucose production and improves peripheral glucose uptake.
• Helps achieve better overall glycemic control, including fasting and postprandial blood glucose levels, in patients with type 2 diabetes.
• May help reduce the risk of diabetes-related complications when used long term as part of a comprehensive management plan including diet and exercise.
• Combination in a single tablet improves treatment convenience and may enhance adherence compared to taking separate vildagliptin and metformin tablets.

Warnings & Contraindications:

• Contraindicated in patients with known hypersensitivity to vildagliptin, metformin, or any of the excipients.
• Contraindicated in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.
• Contraindicated in patients with severe renal impairment or significant reduction in kidney function, due to increased risk of lactic acidosis from metformin.
• Use with caution in patients with hepatic impairment, heart failure, dehydration, severe infection, or conditions associated with hypoxia, as these may increase the risk of lactic acidosis.
• Discontinue temporarily before major surgery or procedures involving iodinated contrast media and follow your doctor’s instructions regarding restarting therapy.
• Consult your doctor before use if pregnant, planning pregnancy, or breastfeeding. Insulin may be preferred during pregnancy.
• Consult your doctor before use if you have liver disease, kidney disease, heart disease, history of pancreatitis, alcohol abuse, or any serious acute illness.
• Avoid excessive alcohol intake while using this medicine, as it increases the risk of lactic acidosis.
• Not intended to diagnose, treat, cure, or prevent any disease without medical supervision; it is a prescription-only medicine that must be used under a healthcare provider’s guidance.
• Keep out of reach of children.

Side Effects:

• Common side effects may include nausea, vomiting, diarrhea, abdominal discomfort, loss of appetite, headache, dizziness, or mild upper respiratory symptoms.
• Metformin-related gastrointestinal symptoms often improve when taken with food and may decrease over time.
• Rare but serious side effect: lactic acidosis (a medical emergency) characterized by deep and rapid breathing, severe weakness, unusual muscle pain, abdominal pain, feeling cold, dizziness, or slow/irregular heartbeat. Stop the medicine and seek immediate medical attention if these occur.
• Vildagliptin may rarely cause liver function abnormalities or pancreatitis (symptoms include severe, persistent abdominal pain, sometimes radiating to the back, with or without vomiting). Contact your doctor immediately if these symptoms appear.
• Hypoglycemia (low blood sugar) is more likely when used in combination with other anti-diabetic agents such as sulfonylureas or insulin. Symptoms include sweating, trembling, palpitations, hunger, confusion, or blurred vision. Treat promptly according to your doctor’s advice.
• If you experience any severe, persistent, or unusual side effects, stop the medication and consult your healthcare provider.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Strength: 50 mg vildagliptin + 1000 mg metformin hydrochloride per tablet.
• Form: Film-coated tablets for oral administration.
• Pack size: 30 tablets per pack (30 tabs) – quantity suitable for typical 2–4 weeks of therapy depending on prescribed dose.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.