Glucovance 1000/5 Mg 30 Flim Coated Tablets

Glucovance 1000/5 Mg 30 Flim Coated Tablets

Description:

Glucovance 1000/5 mg film coated tablets is a prescription oral anti-diabetic medicine used in the management of type 2 diabetes mellitus. It combines two well-established active ingredients, metformin (a biguanide) and glibenclamide (glyburide) (a sulfonylurea), in one tablet to help control blood glucose levels when diet, exercise, and metformin alone are not sufficient. This fixed-dose combination targets high blood sugar through complementary mechanisms: reducing glucose production in the liver, improving insulin sensitivity, and stimulating insulin release from the pancreas. It is intended for adult patients under medical supervision as part of a comprehensive diabetes care plan including diet, physical activity, and regular blood glucose monitoring.

Indications:

• Management of type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus) in adults.
• Indicated when blood glucose levels are not adequately controlled by metformin alone, glibenclamide alone, or diet and exercise alone.
• Helps reduce elevated fasting blood glucose and postprandial (after-meal) blood glucose.
• Used to help reduce the risk of long-term diabetes complications associated with poor glycemic control, such as neuropathy, nephropathy, retinopathy, and cardiovascular disease, as part of an overall treatment strategy.

Active Ingredients / Key Components:

• Metformin hydrochloride – 1000 mg per film coated tablet (biguanide oral anti-diabetic).
• Glibenclamide (glyburide) – 5 mg per film coated tablet (sulfonylurea oral anti-diabetic).
• Excipients: film coating and tablet core excipients (such as fillers, binders, disintegrants, and colorants) – exact composition and concentrations are not available in the provided information. Refer to the official package leaflet for full excipient list.

Dosage & Administration / How to Use:

• Glucovance 1000/5 mg must be used exactly as prescribed by your physician. Do not change your dose without medical advice.
• Typical dosing is 1 tablet once or twice daily, but the exact dose, frequency, and maximum daily dose are individualized based on blood glucose response and tolerance. Follow your doctor’s instructions.
• Take the tablets with meals (usually with breakfast and/or the main meal) to reduce the risk of gastrointestinal side effects from metformin and hypoglycemia from glibenclamide.
• Swallow the film coated tablet whole with a glass of water. Do not crush or chew unless your doctor or pharmacist specifically advises otherwise.
• If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not double the dose to make up for a missed tablet.
• Use in adults only; not recommended in children or adolescents unless specifically directed by a specialist.
• Always combine with a suitable diabetic diet, regular physical activity, and blood glucose monitoring as advised by your healthcare provider.

Clinical Benefits:

• Dual mechanism glucose control: Metformin decreases hepatic glucose production and improves insulin sensitivity, while glibenclamide increases insulin secretion from pancreatic beta cells.
• Improves fasting and post-meal blood sugar: Helps achieve better overall glycemic control in type 2 diabetes when monotherapy is insufficient.
• Supports long-term diabetes management: Better blood sugar control may help reduce the risk of microvascular and macrovascular complications when used as part of a comprehensive treatment plan.
• Convenient fixed-dose combination: Combines two active ingredients in one tablet, potentially improving treatment adherence compared to taking separate tablets.

Warnings & Contraindications:

• Use only under the supervision of a qualified healthcare professional. Do not use without a prescription.
• Contraindicated in patients with type 1 diabetes mellitus, diabetic ketoacidosis, severe renal impairment, acute or chronic metabolic acidosis (including lactic acidosis), severe liver disease, or known hypersensitivity to metformin, glibenclamide, sulfonylureas, or any excipients.
• Metformin is associated with a rare but serious risk of lactic acidosis, especially in patients with kidney dysfunction, dehydration, severe infection, heart failure, liver impairment, or in situations of hypoxia (e.g., respiratory failure, recent myocardial infarction). Seek urgent medical attention if you develop symptoms such as rapid breathing, muscle pain, abdominal pain, severe weakness, or unusual drowsiness.
• Glibenclamide may cause hypoglycemia (low blood sugar), particularly in elderly patients, those with irregular meal patterns, strenuous exercise, alcohol intake, or renal/hepatic impairment. Recognize symptoms such as sweating, tremor, hunger, palpitations, confusion, or blurred vision.
• Use with caution in elderly patients, those with adrenal or pituitary insufficiency, malnutrition, or chronic alcohol use.
• Inform your doctor about all medicines you are taking. The hypoglycemic effect of glibenclamide can be enhanced by certain drugs such as anticoagulants, androgens, chloramphenicol, clofibrate, fenfluramine, fluconazole, gemfibrozil, some histamine H2 antagonists, magnesium salts, and others, increasing the risk of low blood sugar.
• Before contrast imaging procedures with iodinated contrast agents or major surgery, metformin may need to be temporarily discontinued as advised by your doctor.
• Consult your doctor before use if you are pregnant, planning pregnancy, or breastfeeding. Insulin may be preferred in pregnancy.
• Avoid excessive alcohol intake while taking Glucovance, as it can increase the risk of lactic acidosis and hypoglycemia.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical supervision. It is a prescription medicine for the treatment of type 2 diabetes as directed by your doctor.
• Keep out of reach of children.

Side Effects:

• Common side effects (metformin-related): Nausea, vomiting, diarrhea, abdominal discomfort, loss of appetite, metallic taste. These are often mild and may decrease over time, especially when taken with food.
• Common side effects (glibenclamide-related): Hypoglycemia (low blood sugar) with symptoms such as sweating, shakiness, dizziness, headache, hunger, palpitations, or confusion.
• Less common side effects: Skin reactions (rash, itching), photosensitivity, mild weight gain (mainly due to sulfonylurea component), elevated liver enzymes.
• Serious side effects (seek immediate medical attention): Signs of lactic acidosis (rapid breathing, severe weakness, abdominal pain, unusual sleepiness), severe hypoglycemia, jaundice, severe allergic reactions (swelling of face, lips, tongue, throat, or difficulty breathing).
• If you experience any persistent, bothersome, or unexpected side effects, contact your doctor or pharmacist promptly.

Storage Instructions:

Store in a cool, dry place away from direct sunlight and moisture. Keep the blister pack or container tightly closed. Do not store above the temperature specified on the package (typically below 25–30°c, refer to the pack). Keep out of reach of children. Do not use after the expiry date printed on the pack.

Specifications:

• Product type: Prescription oral anti-diabetic medicine.
• Form: Film coated tablet.
• Strength per tablet: metformin 1000 mg + glibenclamide 5 mg.
• Pack size: 30 film coated tablets per pack.
• Intended users: Adults with type 2 diabetes mellitus, as prescribed by a healthcare professional.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.