Gluokan 5/500 Mg 30 Tablets

Gluokan 5/500 Mg 30 Tablets

Description:

Gluokan 5/500 mg 30 tablets is an oral antidiabetic prescription medicine combining two active ingredients, glibenclamide (glyburide) and metformin, for the management of type 2 diabetes mellitus in adults. It belongs to the class of sulfonylureas (glibenclamide) and biguanides (metformin), working together to improve blood glucose control when diet and exercise alone are insufficient. This fixed-dose combination helps reduce elevated blood sugar levels, supports long-term glycemic control, and may decrease the risk of diabetes-related complications when used as part of a comprehensive diabetes care plan.

Indications:

• Management of type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus) in adults.
• Indicated in patients whose blood glucose levels are not adequately controlled by diet, exercise, and metformin or sulfonylurea monotherapy alone.
• Helps reduce fasting and postprandial (after-meal) blood glucose levels.
• Used to improve overall glycemic control and help prevent or delay diabetes-related complications such as neuropathy, nephropathy, retinopathy, and cardiovascular disease when used as part of a full treatment plan.

Active Ingredients / Key Components:

• Glibenclamide (Glyburide) – 5 mg per film-coated tablet.
• Metformin hydrochloride – 500 mg per film-coated tablet.
• Excipients and tablet core/coat ingredients (such as fillers, binders, film-coating agents, and stabilizers) are present but detailed composition is not available in the provided information.

Dosage & Administration / How to Use:

• Dosage must always be individualized by the treating physician based on blood glucose levels, prior therapy, and patient response.
• Typical starting dose (for patients switched from monotherapy) is usually 1 tablet once or twice daily, taken with meals, but the exact regimen should be determined by the doctor.
• Tablets should be swallowed whole with a glass of water and taken with food to reduce gastrointestinal side effects and the risk of hypoglycemia.
• Do not crush or chew the tablets unless your doctor or pharmacist specifically advises otherwise.
• Regular monitoring of blood glucose and HbA1c is recommended to adjust dose and assess treatment effectiveness.
• If a dose is missed, take it as soon as you remember with food, unless it is almost time for the next dose. Do not double the dose to make up for a missed dose.
• Use only under medical supervision. Do not change the dose or stop the medication without consulting your doctor.

Clinical Benefits:

• Provides dual mechanism of action: glibenclamide increases insulin secretion from pancreatic beta cells, while metformin reduces hepatic glucose production and improves peripheral insulin sensitivity.
• Helps achieve better glycemic control compared to monotherapy in many patients with type 2 diabetes.
• Metformin component may help improve lipid profile (lower triglycerides and LDL cholesterol) in type 2 diabetics and may support weight neutrality or modest weight reduction.
• Assists in lowering fasting and postprandial blood glucose levels, helping to maintain more stable daily blood sugar patterns.
• When used consistently with diet, exercise, and regular monitoring, it may help reduce the risk of long-term diabetes complications affecting the eyes, kidneys, nerves, and cardiovascular system.

Warnings & Contraindications:

• Use only under the supervision of a healthcare professional experienced in the management of diabetes.
• Contraindicated in patients with type 1 diabetes mellitus, diabetic ketoacidosis, or diabetic pre-coma.
• Contraindicated in severe renal impairment or significant renal dysfunction due to increased risk of lactic acidosis associated with metformin.
• Contraindicated in severe hepatic impairment, severe cardiac or respiratory failure, recent myocardial infarction, shock, or conditions associated with hypoxia.
• Do not use in patients with known hypersensitivity or allergy to glibenclamide, metformin, other sulfonylureas, sulfonamides, or any component of the formulation.
• Increased risk of hypoglycemia due to glibenclamide, especially in elderly patients, those with irregular meals, intense physical exercise, or concomitant use of other hypoglycemic agents.
• Metformin may cause lactic acidosis, a rare but serious metabolic complication; risk is higher in renal impairment, dehydration, alcohol abuse, or conditions causing tissue hypoxia.
• Temporary discontinuation of metformin-containing products is recommended before and after iodinated contrast imaging procedures or major surgery, as advised by your doctor.
• Alcohol intake should be limited or avoided due to increased risk of hypoglycemia (with glibenclamide) and lactic acidosis (with metformin).
• Consult your doctor before use if pregnant, planning pregnancy, or breastfeeding; insulin may be preferred during pregnancy.
• Use with caution in elderly, malnourished, or debilitated patients, and in those with adrenal, pituitary, or thyroid insufficiency.
• Drug interactions: the hypoglycemic effect of glibenclamide may be enhanced by anticoagulants, androgens, chloramphenicol, clofibrate, fenfluramine, fluconazole, gemfibrozil, histamine H2 antagonists, magnesium salts, methyl- and other interacting drugs; always inform your doctor about all medicines and supplements you are taking.
• May impair ability to drive or operate machinery if hypoglycemia occurs; caution is advised until you know how the medicine affects you.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical supervision; it is a prescription antidiabetic medicine.
• Keep out of reach of children.

Side Effects:

• Common side effects (usually mild and often transient): gastrointestinal disturbances such as nausea, vomiting, abdominal discomfort, diarrhea, metallic taste, and loss of appetite (mainly due to metformin), especially at the start of therapy.
• Hypoglycemia (low blood sugar) due to glibenclamide: symptoms may include sweating, tremor, hunger, palpitations, headache, dizziness, confusion, irritability, blurred vision, or, in severe cases, loss of consciousness or seizures.
• Possible weight gain related to the sulfonylurea component (glibenclamide).
• Rare but serious side effect: lactic acidosis with metformin, characterized by rapid breathing, abdominal pain, severe weakness, muscle cramps, drowsiness, and feeling cold; this is a medical emergency—stop the medicine and seek immediate medical attention.
• Allergic reactions (rare): rash, itching, urticaria, photosensitivity, or more severe reactions; discontinue and consult a doctor if signs of hypersensitivity occur.
• Long-term metformin use may be associated with decreased vitamin B12 absorption; periodic monitoring may be recommended in long-term therapy.
• If you experience persistent or severe side effects, or any symptoms of hypoglycemia or lactic acidosis, seek medical advice promptly.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Product type: Oral antidiabetic prescription medicine.
• Active ingredients: glibenclamide 5 mg + metformin hydrochloride 500 mg per film-coated tablet.
• Form: Film-coated tablet.
• Pack size: 30 tablets per pack.
• Intended use: Adult management of type 2 diabetes mellitus under medical supervision.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.