Glybofen 2.5/500mg 30 RAMEDA

Glybofen 2.5/500mg 30 RAMEDA

Description:

Glybofen 2.5/500mg is an oral antidiabetic medicine combining glibenclamide (a sulfonylurea) and metformin (a biguanide) in one film-coated tablet, manufactured by RAMEDA. It is used in the management of type 2 diabetes mellitus in adults when blood glucose levels are not adequately controlled by diet, exercise, or metformin alone. By combining two complementary mechanisms of action, Glybofen helps lower high blood sugar, improve glycemic control, and reduce the risk of diabetes-related complications when used as part of a comprehensive diabetes care plan.

Indications:

• Type 2 diabetes mellitus (non–insulin-dependent diabetes mellitus) in adults.
• Patients insufficiently controlled on metformin alone, glibenclamide alone, or diet and exercise alone.
• Helps control elevated fasting and postprandial (after-meal) blood glucose levels.
• Used as part of a long-term diabetes management plan to help reduce the risk of complications such as neuropathy, nephropathy, retinopathy, and cardiovascular disease, when combined with lifestyle modifications.

Active Ingredients / Key Components:

• Glibenclamide (Glyburide) – 2.5 mg per film-coated tablet.
• Metformin hydrochloride – 500 mg per film-coated tablet.
• Other excipients (tablet core and film coating) are present but detailed composition is not available in the provided information.

Dosage & Administration / How to Use:

• Dosage must be individualized by the physician based on blood glucose response, previous therapy, and patient profile.
• Typical starting dose (for adults previously on metformin or sulfonylurea alone) is usually 1 tablet once or twice daily, then adjusted according to blood glucose monitoring and medical advice. Exact dosing regimen should be determined by the treating doctor.
• Take the tablets orally with meals to reduce gastrointestinal side effects and the risk of hypoglycemia.
• Swallow the tablet whole with a glass of water. Do not crush or chew unless directed by your healthcare provider.
• Use regularly at the same times each day for optimal blood sugar control.
• If a dose is missed, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to make up for a missed one.
• Always follow your doctor’s instructions regarding diet, exercise, and blood glucose monitoring while using Glybofen.

Clinical Benefits:

• Provides dual mechanism of action: glibenclamide increases insulin secretion from pancreatic beta cells, while metformin reduces hepatic glucose production and improves peripheral glucose uptake.
• Helps achieve better overall glycemic control (fasting and postprandial blood glucose, and HbA1c) compared to monotherapy in appropriate patients.
• Metformin component may improve insulin sensitivity and support a more favorable lipid profile in type 2 diabetics.
• Convenient fixed-dose combination reduces pill burden and may improve treatment adherence.
• Supports long-term management of type 2 diabetes when combined with lifestyle modifications, potentially reducing the risk of microvascular and macrovascular complications.

Warnings & Contraindications:

• Do not use in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.
• Contraindicated in severe renal impairment or significant kidney disease due to the risk of lactic acidosis from metformin.
• Contraindicated in severe hepatic impairment, acute alcohol intoxication, or chronic alcoholism.
• Do not use in patients with known hypersensitivity or allergy to glibenclamide, metformin, other sulfonylureas, or any component of the product.
• Use with caution in elderly, malnourished, debilitated patients, or those with adrenal, pituitary, or hepatic insufficiency due to increased risk of hypoglycemia.
• Temporary discontinuation may be required before and after radiologic studies with iodinated contrast media or major surgery (as advised by the physician) because of lactic acidosis risk.
• Alcohol intake should be limited or avoided, as it may potentiate the effect of metformin on lactate metabolism and increase hypoglycemia risk with glibenclamide.
• Consult your doctor before use if pregnant, planning pregnancy, or breastfeeding; insulin is often preferred during pregnancy.
• Consult your doctor before use if you have heart failure, recent myocardial infarction, respiratory failure, severe infection, dehydration, or other serious conditions.
• May cause hypoglycemia; caution is advised when driving or operating machinery, especially at treatment initiation or after dose changes.
• Consult your doctor before use if you are taking other medications such as anticoagulants, androgens, chloramphenicol, clofibrate, fenfluramine, fluconazole, gemfibrozil, histamine h2 antagonists, magnesium salts, methyl derivatives, diuretics, corticosteroids, beta-blockers, or other antidiabetic agents, as interactions may alter blood glucose levels.
• Not intended to diagnose, treat, cure, or prevent any disease without medical supervision.
• Keep out of reach of children.

Side Effects:

• Common side effects (usually related to metformin) may include gastrointestinal disturbances such as nausea, vomiting, diarrhea, abdominal discomfort, and loss of appetite, especially at the start of therapy.
• Hypoglycemia (low blood sugar) can occur, especially if meals are skipped, during intense exercise, with alcohol intake, or when combined with other antidiabetic drugs. Symptoms include sweating, tremor, hunger, palpitations, dizziness, confusion, or blurred vision.
• Rare but serious side effect: lactic acidosis associated with metformin, characterized by rapid breathing, severe weakness, muscle pain, abdominal pain, irregular heartbeat, or feeling very unwell. This is a medical emergency and requires immediate medical attention.
• Allergic reactions such as rash, itching, or swelling may occur; discontinue and seek medical help if severe reactions appear.
• Long-term use of metformin may be associated with decreased vitamin b12 absorption in some patients.
• If you experience persistent or severe side effects, or signs of hypoglycemia or lactic acidosis, stop the medication and contact your doctor or seek emergency care immediately.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Form: Film-coated tablets.
• Strength: 2.5 mg glibenclamide + 500 mg metformin hydrochloride per tablet.
• Pack size: 30 film-coated tablets per pack.
• Route of administration: Oral.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.