Humulin 70/30

Humulin 70/30

Description:

Humulin 70/30 100 i.u. is a premixed human insulin suspension used as a prescription diabetes medicine to control high blood sugar in adults and children with type 1 and type 2 diabetes mellitus. It contains 70% insulin isophane protamine human (intermediate-acting) and 30% insulin neutral human (short-acting), providing both rapid onset and prolonged glucose-lowering action in a single injection. Humulin 70/30 is supplied in 5 cartridges for use with compatible insulin pens and is used as an adjunct to diet, exercise, and regular blood glucose monitoring to help achieve stable glycemic control and reduce the risk of diabetes-related complications.

Indications:

• Indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 1 diabetes mellitus.
• Indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 2 diabetes mellitus when oral antidiabetic agents alone are insufficient.
• Management of fasting and postprandial (after-meal) hyperglycemia.
• Helps reduce symptoms of uncontrolled diabetes such as excessive thirst, frequent urination, fatigue, and blurred vision when used as prescribed.

Active Ingredients / Key Components:

• Insulin neutral human (regular human insulin) – 30% of total 100 i.u. per ml (exact i.u. per ml for each component not specified in provided data).
• Insulin isophane protamine human (NPH human insulin) – 70% of total 100 i.u. per ml (exact i.u. per ml for each component not specified in provided data).
• Other excipients: Full excipient list and concentrations , please check the product leaflet or the manufacturer’s official website. Refer to the official package insert for complete details.

Dosage & Administration / How to Use:

• Humulin 70/30 is for subcutaneous injection only. Do not administer intravenously or intramuscularly.
• Usual dosing, timing, and total daily units must be individualized by the treating physician based on blood glucose monitoring, type of diabetes, body weight, diet, physical activity, and concomitant medications.
• Typically administered within 30 minutes before a meal to cover both immediate and intermediate insulin needs; dosing frequency is often once or twice daily, but exact regimen must be determined by a healthcare professional.
• Use only with compatible insulin pen devices designed for Humulin cartridges. Follow pen manufacturer’s instructions for loading the cartridge, priming, and injection.
• Before injection, gently roll the cartridge between the palms and invert it several times until the suspension appears uniformly cloudy. Do not use if the insulin remains clear, has clumps, particles, or appears unusually thick.
• Inject into recommended subcutaneous areas such as the abdomen, thigh, upper arm, or buttocks. Rotate injection sites within the same region to reduce the risk of lipodystrophy (thickening or thinning of the skin).
• Do not share insulin pens, cartridges, or needles with anyone, even if the needle is changed, to prevent cross-contamination and infection.
• If a dose is missed, follow your doctor’s instructions. Do not double the next dose to make up for a missed one. Monitor blood glucose and seek medical advice if levels are significantly high or low.
• Use with regular self-monitoring of blood glucose (and HbA1c as advised) to allow dose adjustments by your healthcare provider.

Clinical Benefits:

• Provides dual-phase insulin action (short-acting and intermediate-acting) in one injection to help control both post-meal and between-meal blood glucose levels.
• Supports improved glycemic control in type 1 and type 2 diabetes, helping reduce the risk of long-term complications such as neuropathy, nephropathy, retinopathy, and cardiovascular disease when used as part of a comprehensive diabetes management plan.
• Offers convenient premixed formulation, reducing the need to mix separate insulins and simplifying insulin regimens for many patients.
• Helps alleviate symptoms of hyperglycemia (excessive thirst, frequent urination, tiredness) when blood glucose is brought under control.

Warnings & Contraindications:

• For use only under medical supervision. Incorrect dosing or administration can cause severe hypoglycemia or hyperglycemia, which may be life-threatening.
• Contraindicated during episodes of hypoglycemia (low blood sugar). Do not inject if your blood glucose is already low; treat hypoglycemia first and contact your doctor for guidance.
• Contraindicated in patients with known hypersensitivity to human insulin or any component of the formulation.
• Use with extreme caution in patients with renal or hepatic impairment, as insulin requirements may be reduced and risk of hypoglycemia increased.
• Dosage adjustments may be required during illness, stress, changes in diet, physical activity, or when switching from other insulin products. Such changes must be supervised by a healthcare professional.
• Alcohol, certain medications (e.g., oral antidiabetics, beta-blockers, ACE inhibitors, corticosteroids, diuretics, and others) can alter insulin effect and blood glucose levels. Inform your doctor about all medicines and supplements you are taking.
• Beta-blockers and some other drugs may mask the symptoms of hypoglycemia (such as palpitations or tremor). Patients should be educated to recognize other signs like sweating or sudden fatigue.
• Consult your doctor before use if pregnant, planning pregnancy, or breastfeeding. Insulin needs often change during pregnancy and postpartum and require close monitoring.
• Use caution when driving or operating machinery, especially when initiating insulin therapy or when dose is changed, as hypoglycemia can impair concentration and reaction time.
• Keep out of reach of children. Accidental use by children can cause severe hypoglycemia.
• This product is a prescription medicine specifically intended to treat and manage diabetes mellitus under medical guidance.

Side Effects:

• Common side effects: Hypoglycemia (low blood sugar) is the most frequent adverse effect and may present with sweating, shakiness, palpitations, hunger, headache, dizziness, irritability, confusion, or blurred vision. Mild hypoglycemia should be treated promptly with fast-acting carbohydrates (e.g., glucose tablets, juice).
• Local reactions at injection site: Redness, swelling, itching, or mild pain may occur and usually resolve with continued use. Rotation of injection sites helps reduce these reactions.
• Lipodystrophy: Thickening or thinning of the fatty tissue at injection sites can occur with repeated injections in the same area.
• Allergic reactions: Rarely, generalized allergy (rash, itching, shortness of breath, wheezing, low blood pressure, rapid heartbeat, or sweating) may occur. This can be serious and requires immediate medical attention.
• Edema and weight gain: May occur, particularly when improving previously poor glycemic control or when used with other antidiabetic agents.
• Seek immediate medical attention if you experience severe hypoglycemia (confusion, seizures, loss of consciousness), signs of severe allergic reaction, or persistent, unexplained side effects.

Storage Instructions:

Store unopened Humulin 70/30 cartridges in a refrigerator at 2–8°c. Do not freeze. Do not use if the product has been frozen. Once in use, storage conditions and in-use shelf life should follow the official package insert; typically, in-use cartridges may be kept at room temperature below 25–30°c for a limited period (exact duration not provided in the available information (For full ingredient information, please check the product leaflet or the manufacturer’s official website.)). Protect from direct heat and light. Keep the cartridge in its carton until use. Do not expose to excessive heat. Keep container tightly closed where applicable and keep out of reach of children.

Specifications:

• Product type: Prescription insulin medicine for diabetes management.
• Form: Suspension for injection in cartridge format for use with compatible insulin pens.
• Strength: 100 i.u./ml (total human insulin content); premixed 70% insulin isophane protamine human and 30% insulin neutral human. Exact i.u. breakdown per component per ml is not specified in the provided data.
• Pack size: 5 cartridges (exact volume per cartridge not specified in the provided information).
• Route of administration: Subcutaneous injection.
• Intended users: Adults and children with type 1 or type 2 diabetes mellitus, as prescribed by a healthcare professional.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.