IMUTREXATE 2.5MG 10TAB

IMUTREXATE 2.5MG 10TAB

Description:

IMUTREXATE 2.5mg 10tab is a prescription systemic medicine containing methotrexate, an antimetabolite, antifolate, immunosuppressant, antineoplastic, and antirheumatic agent. It is used in low doses for chronic inflammatory and autoimmune diseases such as rheumatoid arthritis and psoriasis, and in higher or specialized regimens as part of chemotherapy protocols for certain cancers. IMUTREXATE works by inhibiting dihydrofolate reductase, reducing folic acid–dependent DNA and RNA synthesis, thereby suppressing rapidly dividing cells and modulating immune activity. This product is intended for use only under strict medical supervision and individualized dosing by a specialist.

Indications:

• Rheumatoid arthritis (RA) in adults, as a disease-modifying antirheumatic drug (DMARD), to reduce joint inflammation, pain, and structural damage (as directed by a rheumatologist).
• Severe, recalcitrant, disabling psoriasis that is not adequately responsive to other forms of therapy and only under the supervision of a dermatologist experienced in systemic therapy.
• Part of combination chemotherapy regimens for certain malignancies such as acute lymphoblastic leukemia (ALL), choriocarcinoma, Burkitt's lymphoma, meningeal leukemia, lymphosarcoma, hydatidiform mole, non‑metastatic osteosarcoma, and mycosis fungoides (as per oncology protocols).
• Other immune-mediated conditions such as some cases of corticosteroid‑dependent asthma or other autoimmune diseases, only when specifically prescribed by a specialist.
• Helps control symptoms such as joint pain, swelling, stiffness, skin plaques in psoriasis, and disease progression in indicated cancers, when used as part of a comprehensive treatment plan.

Active Ingredients / Key Components:

• Methotrexate – 2.5 mg per tablet.
• Excipients (inactive ingredients such as fillers, binders, and coating agents) – exact composition not available in the provided information; refer to the package leaflet for full excipient list.

Dosage & Administration / How to Use:

• IMUTREXATE 2.5mg 10tab must only be used exactly as prescribed by your doctor. Never adjust the dose or schedule on your own.
• Rheumatoid arthritis / Psoriasis (low‑dose therapy): Methotrexate is typically given once weekly, not daily. The total weekly dose and number of 2.5 mg tablets are determined individually by the physician. Taking methotrexate daily instead of weekly can cause severe and potentially fatal toxicity.
• Oncologic indications: Dose, frequency, and duration vary widely depending on the cancer type, treatment protocol, and patient factors. It may be given orally, intramuscularly, intravenously, or intrathecally. Follow the exact oncology regimen provided by your specialist.
• Tablets should usually be swallowed whole with water, with or without food, at the time specified by your doctor. Do not crush or chew unless your doctor or pharmacist advises otherwise.
• Your doctor may prescribe folic acid supplementation on days you are not taking methotrexate to reduce some side effects. Follow these instructions carefully.
• Regular blood tests (complete blood count, liver and kidney function, etc.) and clinical monitoring are essential during treatment to detect toxicity early.
• If you miss a dose, contact your doctor or pharmacist immediately for advice. Do not double the next dose or take extra tablets without medical guidance.
• Do not stop methotrexate abruptly unless your doctor instructs you to do so, especially in oncology protocols. For RA/psoriasis, dose tapering may be required.

Clinical Benefits:

• Provides disease‑modifying control in rheumatoid arthritis by reducing joint inflammation, pain, and stiffness, and slowing structural joint damage.
• Improves severe psoriasis by reducing excessive skin cell proliferation and plaque formation, leading to smoother, clearer skin over time.
• Acts as a key antineoplastic agent in specific chemotherapy regimens, helping inhibit growth and spread of certain malignant cells.
• Offers immunosuppressive and anti‑inflammatory effects in selected autoimmune and inflammatory conditions when other treatments are inadequate.

Warnings & Contraindications:

• Methotrexate is a potent medicine with potentially serious or life‑threatening side effects. It must be prescribed and monitored by a specialist experienced in its use.
• Contraindications (do not use unless your doctor decides otherwise): severe liver disease, significant kidney impairment, severe bone marrow suppression, active serious infections, severe immunodeficiency, pregnancy, breastfeeding, known hypersensitivity to methotrexate or any component of the product, and chronic alcohol abuse.
• Pregnancy and fertility: Methotrexate is highly teratogenic and can cause fetal death or congenital abnormalities. It must not be used during pregnancy. Effective contraception is required for both women and men during treatment and for a recommended period after stopping (follow your doctor’s advice).
• Breastfeeding: Contraindicated. Methotrexate passes into breast milk and may harm the infant.
• Liver toxicity: Use with extreme caution in patients with liver disease, history of hepatitis, or regular alcohol consumption. Avoid alcohol during treatment. Regular liver function tests are mandatory.
• Kidney function: Impaired renal function increases the risk of toxicity. Dose adjustment and close monitoring are required in renal impairment.
• Bone marrow suppression: Methotrexate can cause leukopenia, thrombocytopenia, and anemia. Regular blood counts are essential. Report signs of infection, unusual bruising, or bleeding immediately.
• Infections: Avoid use in active serious infections. Methotrexate suppresses the immune system and may increase susceptibility to infections or worsen existing ones.
• Lung toxicity: Methotrexate can cause interstitial pneumonitis and pulmonary fibrosis. Report persistent dry cough, shortness of breath, or chest pain promptly.
• Gastrointestinal toxicity: Severe mouth ulcers, vomiting, diarrhea, or gastrointestinal bleeding may occur, especially with overdose or incorrect dosing.
• Avoid live vaccines during methotrexate therapy unless your doctor specifically advises otherwise.
• Inform your doctor about all medicines, supplements, or herbal products you are taking, especially NSAIDs, antibiotics (e.g., trimethoprim‑sulfamethoxazole), proton pump inhibitors, other immunosuppressants, and nephrotoxic or hepatotoxic drugs, due to potential interactions.
• Consult your doctor before use if you have liver disease, kidney disease, blood disorders, peptic ulcer disease, diabetes, obesity, or are elderly, as the risk of toxicity may be higher.
• Keep out of reach of children. Accidental ingestion can be fatal.
• This product is a prescription medicine and must not be used for self‑medication.

Side Effects:

• Common side effects: Nausea, vomiting, loss of appetite, abdominal discomfort, fatigue, headache, dizziness, mild hair thinning, and mouth sores (stomatitis). These may be reduced by folic acid supplementation as advised by your doctor.
• Hematologic effects: Decreased white blood cells, red blood cells, or platelets, leading to increased risk of infections, anemia, bruising, or bleeding.
• Hepatic effects: Elevated liver enzymes, liver inflammation, and, with long‑term use, risk of liver fibrosis or cirrhosis. Regular liver function monitoring is required.
• Renal effects: Worsening kidney function, especially at higher doses or in patients with pre‑existing renal impairment.
• Respiratory effects: Dry cough, shortness of breath, fever, or chest pain may indicate methotrexate‑induced pneumonitis; seek urgent medical attention.
• Dermatologic effects: Skin rash, photosensitivity, itching, or worsening of skin lesions in some cases.
• Serious reactions (seek immediate medical attention): Severe or persistent vomiting or diarrhea, black or bloody stools, severe mouth ulcers, yellowing of the skin or eyes, dark urine, severe fatigue, confusion, chest pain, difficulty breathing, high fever, severe sore throat, unusual bruising or bleeding, or signs of severe allergic reaction (swelling of face/lips/tongue, difficulty breathing).
• Not all possible side effects are listed. Always report any new, persistent, or severe symptoms to your doctor or pharmacist.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Active ingredient: Methotrexate 2.5 mg per tablet.
• Form: Oral tablet.
• Pack size: 10 tablets per pack.
• Intended use: Prescription systemic medicine for selected autoimmune diseases and specific cancers, under specialist supervision.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.