Livial 2.5 Mg Tablets

Livial 2.5 Mg Tablets

Description:

Livial 2.5 mg tablets are a prescription hormonal medicine containing tibolone, a synthetic steroid hormone used as hormone replacement therapy (HRT) for postmenopausal women. Tibolone has tissue-selective estrogenic, progestogenic, and weak androgenic activity, helping relieve menopausal symptoms and prevent postmenopausal osteoporosis. Livial 2.5 mg is indicated for women at least 1 year after their last natural menstrual period and should be used under strict medical supervision.

Indications:

• Hormone replacement therapy (HRT) for postmenopausal women at least 12 months after natural menopause.
• Treatment of menopausal vasomotor symptoms due to estrogen deficiency, such as hot flushes, night sweats, and sleep disturbances.
• Improvement of urogenital atrophy symptoms, including vaginal dryness, discomfort, and urinary complaints associated with menopause.
• Prevention of osteoporosis in postmenopausal women at increased risk of fractures when alternative non-estrogen treatments are unsuitable.
• Support of mood and psychological well-being related to menopausal hormonal changes (as part of an overall management plan).
• Improvement of libido and sexual function in postmenopausal women with symptoms related to estrogen deficiency.

Active Ingredients / Key Components:

• Tibolone – 2.5 mg per tablet.
• Excipients: Full list of inactive ingredients is not available in the provided data; please refer to the official package leaflet for complete excipient information.

Dosage & Administration / How to Use:

• Usual adult dose: 1 tablet (2.5 mg tibolone) once daily, taken at the same time each day.
• Swallow the tablet whole with water; may be taken with or without food.
• For postmenopausal women only: treatment should start at least 12 months after the last natural menstrual period to reduce the risk of irregular bleeding.
• If switching from another form of continuous combined HRT, you may start Livial 2.5 mg on any convenient day; if switching from cyclic HRT, start the day after completing the cycle. Always follow your doctor’s instructions.
• If you miss a dose and less than 12 hours have passed, take it as soon as you remember. If more than 12 hours have passed, skip the missed dose and take the next tablet at the usual time. Do not take a double dose to make up for a missed tablet.
• Duration of use: Use the lowest effective dose for the shortest duration necessary to control symptoms. Your doctor should review the need for continued treatment at least once a year.
• Not recommended for women under 18 years of age.
• Always use exactly as prescribed by your physician and do not adjust the dose without medical advice.

Clinical Benefits:

• Helps relieve menopausal vasomotor symptoms such as hot flushes and night sweats by restoring hormonal balance.
• Improves urogenital atrophy, helping reduce vaginal dryness, discomfort, and urinary symptoms associated with menopause.
• Supports bone health by increasing bone mineral density and helping prevent postmenopausal osteoporosis and related fractures.
• May improve mood, psychological well-being, and quality of life in postmenopausal women as part of comprehensive menopausal management.
• Enhances libido and sexual function in some postmenopausal women by its androgenic and estrogenic activity.
• Provides tissue-selective hormonal effects designed to alleviate menopausal symptoms without significantly stimulating the endometrium when used as directed.

Warnings & Contraindications:

• Livial 2.5 mg tablets are for postmenopausal women only and must be used under medical supervision.
• Contraindicated in women with known, past, or suspected breast cancer, estrogen-dependent malignant tumors (e.g., endometrial cancer), unexplained vaginal bleeding, untreated endometrial hyperplasia, or a history of venous thromboembolism (deep vein thrombosis, pulmonary embolism).
• Contraindicated in women with active or recent arterial thromboembolic disease (e.g., angina, myocardial infarction, stroke), severe liver disease, or known thrombophilic disorders.
• Do not use if you have or have had benign or malignant liver tumors, porphyria, or known hypersensitivity to tibolone or any excipient.
• Use with caution in women with risk factors for estrogen-related conditions such as breast cancer, endometrial cancer, venous thromboembolism, hypertension, diabetes mellitus, obesity, systemic lupus erythematosus, or a strong family history of hormone-dependent cancers.
• Regular medical follow-up is required, including breast examinations and mammography according to national screening guidelines. Report any breast changes (dimples, lumps, nipple changes) to your doctor immediately.
• Stop treatment and seek urgent medical attention if you develop symptoms of blood clots (painful swelling in leg, sudden chest pain, shortness of breath), stroke (sudden weakness, vision or speech problems), or jaundice.
• Not for use in pregnancy or breastfeeding. If pregnancy occurs, discontinue immediately and consult a doctor.
• Drug interactions: Enzyme-inducing medicines such as rifampicin and certain antiepileptics (carbamazepine, phenobarbitone, phenytoin, primidone) may accelerate tibolone metabolism and reduce its effect. Inform your doctor about all medicines, herbal products, or supplements you are taking.
• Consult your doctor before use if you have liver disease, kidney disease, diabetes, migraine, epilepsy, asthma, or high blood pressure.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical supervision.
• Keep out of reach of children.

Side Effects:

• Common side effects may include abdominal pain, pelvic pain, breast tenderness, vaginal discharge, vaginal bleeding or spotting (especially in the first months of treatment), and weight changes.
• Other possible side effects can include headache, dizziness, edema (swelling of legs or ankles), itching, or skin rash.
• Serious side effects (seek immediate medical attention): signs of blood clots (leg pain/swelling, chest pain, sudden shortness of breath), stroke symptoms (sudden weakness, difficulty speaking, vision problems), jaundice or severe abdominal pain (possible liver problems), or any unusual vaginal bleeding after you have been on treatment for some time.
• If you experience any persistent, bothersome, or unexpected side effects, stop taking the tablets and consult your doctor or pharmacist promptly.

Storage Instructions:

Store in a cool, dry place away from direct sunlight and moisture. Keep the blister pack in the outer carton to protect from light. Do not store above the temperature stated on the pack (typically below 25°c, refer to leaflet). Keep container tightly closed if applicable. Keep out of reach of children.

Specifications:

• Product type: Prescription hormonal medicine (hormone replacement therapy).
• Active ingredient: tibolone 2.5 mg per tablet.
• Form: Tablet.
• Pack size: 28 tablets per pack (28 tab).
• Intended users: Postmenopausal adult women, at least 12 months after last natural menstrual period, under physician supervision.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.