Minirin Melt 120 Mcg Tablets

Minirin Melt 120 Mcg Tablets

Description:

Minirin Melt 120 mcg sublingual tablets are a prescription antidiuretic medicine containing desmopressin acetate, a synthetic analogue of the natural pituitary hormone vasopressin (antidiuretic hormone, ADH). They are designed to dissolve under the tongue (melt formulation) for rapid absorption without the need for water, making them particularly suitable for patients with nocturnal enuresis (bedwetting) or diabetes insipidus who require precise control of urine production. Minirin Melt helps reduce excessive urine output, control frequent urination, and limit night-time urination episodes, thereby improving sleep quality, hydration balance, and overall quality of life.

Indications:

• Central diabetes insipidus: management of excessive urination (polyuria) and excessive thirst (polydipsia) due to deficiency of antidiuretic hormone.
• Nocturnal enuresis (bedwetting) in children and adults: treatment of primary nocturnal enuresis associated with nocturnal polyuria, after organic causes have been excluded.
• Nocturia due to nocturnal polyuria in adults: reduction of night-time urine production and frequency of night-time urination.
• Conditions requiring controlled antidiuretic effect as determined by a physician (e.g. certain cases of post-operative polyuria) – only under specialist supervision.

Active Ingredients / Key Components:

• Desmopressin acetate – 120 mcg per sublingual tablet (melt).
• Other excipients: full excipient list and their exact concentrations , please check the product leaflet or the manufacturer’s official website; please refer to the official package leaflet for complete details.

Dosage & Administration / How to Use:

• Minirin Melt 120 mcg is for sublingual use only. Do not swallow, chew, or crush. Place the tablet under the tongue and allow it to dissolve completely.
• Take with a dry mouth. Do not drink water while the tablet is under the tongue.
• Typical dosing for primary nocturnal enuresis (bedwetting): usually 120 mcg at bedtime; the dose may be adjusted by the doctor (sometimes increased to 240 mcg) according to response and tolerability.
• Central diabetes insipidus: dose and frequency are individualized by the physician based on urine output, serum sodium, and clinical response. Follow your doctor’s exact instructions.
• Nocturia due to nocturnal polyuria: dose and treatment duration must be determined by a healthcare professional, usually taken at bedtime.
• Strictly limit fluid intake from 1 hour before taking Minirin Melt until at least 8 hours after the dose to reduce the risk of water retention and low blood sodium (hyponatremia).
• If you miss a dose, skip the missed dose and take the next dose at the usual time. Do not double the dose.
• Use only under medical supervision and for the duration prescribed by your doctor. Regular monitoring of serum sodium and kidney function may be required, especially in elderly patients or those at risk of fluid and electrolyte imbalance.

Clinical Benefits:

• Reduces excessive urine production by selectively stimulating V2 receptors in the kidney collecting ducts, increasing water reabsorption.
• Helps control symptoms of central diabetes insipidus, including frequent urination and intense thirst, supporting better hydration balance.
• Decreases night-time urine volume and frequency of bedwetting episodes, improving sleep quality and daily functioning for patients and caregivers.
• Convenient sublingual melt formulation allows administration without water, beneficial for children, elderly patients, and those with swallowing difficulties.

Warnings & Contraindications:

• Use only under the supervision of a physician experienced in managing disorders of water balance.
• Contraindicated in patients with known hypersensitivity to desmopressin acetate or any component of the product.
• Contraindicated in conditions associated with fluid overload or risk of fluid retention, such as moderate to severe renal impairment, heart failure, or syndrome of inappropriate antidiuretic hormone secretion (SIADH).
• Do not use in patients with hyponatremia (low blood sodium) or a history of hyponatremia.
• Strict fluid restriction is essential from 1 hour before dose until at least 8 hours after dose to minimize risk of water intoxication and hyponatremia.
• Use with caution in elderly patients, children, and those at risk of electrolyte imbalance, as they are more susceptible to hyponatremia.
• Discontinue treatment and contact a doctor immediately if symptoms of water intoxication or hyponatremia occur (headache, nausea, vomiting, weight gain, confusion, seizures).
• Consult your doctor before use if pregnant, planning pregnancy, or breastfeeding. The doctor will weigh benefits and potential risks.
• Inform your doctor about all other medicines you are taking, especially diuretics, non-steroidal anti-inflammatory drugs (nsaids), antidepressants (such as ssris, tricyclics), antipsychotics, carbamazepine, or other drugs that may affect water and sodium balance.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical evaluation and prescription.
• Keep out of reach of children. Accidental ingestion, especially with unrestricted fluid intake, can be dangerous.

Side Effects:

• Common side effects: headache, mild nausea, abdominal pain, nasal or throat discomfort, dry mouth, or mild fluid retention.
• Less common but serious side effects: hyponatremia (low blood sodium) with symptoms such as headache, nausea, vomiting, drowsiness, confusion, weight gain, muscle cramps, or in severe cases seizures and loss of consciousness. These require immediate medical attention and discontinuation of treatment.
• Allergic reactions (rash, itching, swelling of face, lips, tongue, or throat, difficulty breathing) are rare but require urgent medical care.
• If you experience any unexpected or severe side effects, stop using the product and consult your doctor or pharmacist promptly.

Storage Instructions:

Store in a cool, dry place away from direct sunlight and moisture. Keep the blister pack tightly closed until use to protect the tablets from humidity. Do not store above the temperature recommended on the package insert. Keep out of reach of children.

Specifications:

• Product type: Prescription antidiuretic medicine.
• Active ingredient strength: desmopressin acetate 120 mcg per sublingual tablet.
• Form: sublingual tablet (melt) – dissolves under the tongue without water.
• Pack size: 30 sublingual tablets (as indicated by the product name MINIRIN MELT 120MCG 30 SUBLINGUAL TAB.).
• Intended users: adults and children as prescribed by a physician for central diabetes insipidus, nocturnal enuresis, or nocturnal polyuria.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.