Natrixam 1.5/5 Mg 28 Tablets

Natrixam 1.5/5 Mg 28 Tablets

Description:

Natrixam 1.5/5 mg is a prescription antihypertensive medicine combining two active ingredients, indapamide and amlodipine, in a single modified-release, film-coated tablet. It is used as substitution therapy for adults with essential hypertension who are already well controlled on indapamide and amlodipine taken together at the same dose. By combining a calcium channel blocker (amlodipine) with a thiazide-like diuretic (indapamide), Natrixam helps lower and maintain blood pressure, reducing the risk of cardiovascular events such as stroke and heart attack. This pack contains 28 tablets, providing a 4‑week treatment course when taken once daily as directed by a physician.

Indications:

• Treatment of essential (primary) hypertension in adult patients.
• Substitution therapy in patients already controlled with separate tablets of indapamide and amlodipine at the same dose (1.5 mg indapamide + 5 mg amlodipine).
• Helps reduce elevated blood pressure and maintain long‑term blood pressure control.
• May lower the risk of hypertension-related complications such as stroke, myocardial infarction, and other cardiovascular events when used as part of a comprehensive treatment plan.

Active Ingredients / Key Components:

• Indapamide – 1.5 mg (thiazide-like diuretic, modified-release)
• Amlodipine (as amlodipine besilate) – 5 mg (dihydropyridine calcium channel blocker)
• Other excipients: film-coating and tablet core excipients (full excipient list is not available in the provided information; please refer to the official package leaflet for complete details).

Dosage & Administration / How to Use:

• Usual adult dose: one tablet of Natrixam 1.5/5 mg once daily.
• Take preferably in the morning at the same time each day.
• Swallow the tablet whole with a glass of water; do not crush, break, or chew, to maintain the modified-release profile.
• Can be taken with or without food, as directed by your doctor.
• Use only as substitution therapy if you are already stabilized on indapamide 1.5 mg and amlodipine 5 mg taken concurrently.
• Do not change the dose or stop treatment without consulting your physician, as abrupt discontinuation may cause a rise in blood pressure.
• If you miss a dose, take it as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
• Always follow your doctor’s instructions and the directions on the prescription label.

Clinical Benefits:

• Provides effective blood pressure reduction by combining two complementary antihypertensive mechanisms (vasodilation and mild diuretic effect).
• Once-daily modified-release formulation offers 24‑hour blood pressure control and convenient dosing.
• Single-tablet combination simplifies treatment for patients already taking indapamide and amlodipine separately, which may improve adherence.
• Helps reduce long-term cardiovascular risk associated with uncontrolled hypertension when used as part of a comprehensive management plan (diet, exercise, lifestyle changes).

Warnings & Contraindications:

• Contraindicated in patients with known hypersensitivity to indapamide, amlodipine, other sulfonamides, other dihydropyridine calcium channel blockers, or any excipient in the product.
• Contraindicated in severe renal failure, severe hepatic impairment, decompensated heart failure, cardiogenic shock, or in patients with severe hypotension.
• Do not use in patients with obstruction of the outflow tract of the left ventricle (e.g., high-grade aortic stenosis) without strict medical supervision.
• Use with caution in patients with electrolyte disturbances (such as low potassium or sodium), gout, diabetes, or a history of photosensitivity reactions to thiazide or thiazide-like diuretics.
• May cause dizziness or fatigue; use caution when driving or operating machinery until you know how the medicine affects you.
• Alcohol may enhance the blood pressure-lowering effect and increase dizziness; limit or avoid alcohol as advised by your doctor.
• Consult your doctor before use if pregnant or planning pregnancy. Amlodipine/indapamide should generally be avoided during pregnancy unless clearly needed and prescribed by a specialist.
• Consult your doctor before use if breastfeeding, as data on excretion in human milk are limited; your doctor will weigh the benefits and risks.
• Inform your doctor about all other medicines you are taking, including other antihypertensives, diuretics, lithium, NSAIDs, antidepressants, and any herbal products, to avoid interactions.
• Regular monitoring of blood pressure, kidney function, and electrolytes (especially potassium and sodium) may be required during treatment.
• Not intended for self-medication; use only under medical supervision.
• Keep out of reach of children.

Side Effects:

• Common side effects may include headache, dizziness, flushing, ankle or leg swelling (peripheral edema), palpitations, fatigue, nausea, abdominal pain, or muscle cramps.
• Indapamide may cause changes in electrolytes (low potassium, low sodium), increased uric acid, or slight increases in blood glucose; your doctor may monitor these with blood tests.
• Less common but serious side effects can include severe hypotension, fainting, irregular heartbeat, chest pain, shortness of breath, severe skin reactions, or signs of liver problems (yellowing of skin/eyes, dark urine).
• Allergic reactions such as rash, itching, swelling of the face, lips, tongue, or throat, or difficulty breathing require immediate medical attention.
• If you experience sudden worsening chest pain, severe dizziness, or any unusual or severe symptom, seek urgent medical help.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed in the original blister and carton to protect from moisture. Keep out of reach of children. Do not use after the expiry date stated on the packaging. Do not store above the temperature recommended in the official leaflet (specific temperature information is not available here; refer to the pack for details).

Specifications:

• Product type: Prescription antihypertensive medicine (fixed-dose combination).
• Active ingredients: indapamide 1.5 mg (modified-release) + amlodipine 5 mg.
• Form: film-coated, modified-release tablet.
• Pack size: 28 tablets – typically a 28‑day (4‑week) supply at one tablet per day.
• Route of administration: oral.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.