Nebilet 12.5/5 Mg 14 Tablets

Nebilet 12.5/5 Mg 14 Tablets

Description:

Nebilet 12.5/5 mg 14 tablets (marketed as Nebilet Plus 5/25 mg in some references) is a prescription antihypertensive medicine combining a cardioselective beta-blocker (nebivolol hydrochloride) with a thiazide diuretic (hydrochlorothiazide). It is used for the long-term management of high blood pressure (hypertension) in adults, helping to reduce cardiovascular risk such as heart attack and stroke. Nebivolol lowers blood pressure by blocking beta-1 receptors and promoting vasodilation via nitric oxide release, while hydrochlorothiazide increases urinary excretion of sodium and water to decrease blood volume and blood pressure.

Indications:

• Treatment of essential (primary) hypertension in adults.
• Management of high blood pressure in patients who require combination therapy with a beta-blocker and a thiazide diuretic.
• Helps reduce the risk of cardiovascular complications associated with uncontrolled hypertension, such as heart attack, stroke, and heart failure (as part of an overall risk-reduction plan prescribed by a physician).
• May be used in patients whose blood pressure is not adequately controlled with nebivolol or hydrochlorothiazide alone, as directed by the treating physician.

Active Ingredients / Key Components:

• Nebivolol (as nebivolol hydrochloride) – 5 mg per tablet.
• Hydrochlorothiazide – 12.5 mg per tablet.
• Other inactive ingredients (excipients) may include tablet fillers, binders, and coating agents; detailed excipient list and their concentrations , please check the product leaflet or the manufacturer’s official website.

Dosage & Administration / How to Use:

• Use only as prescribed by a physician. Do not self-medicate or adjust the dose without medical advice.
• Typical adult dose: 1 tablet once daily, preferably at the same time each day. The exact dose and duration are determined by your doctor based on blood pressure response and clinical status.
• Administration: Swallow the tablet whole with a sufficient amount of water. Do not crush, chew, or break the tablet unless your doctor or pharmacist specifically instructs you to.
• With or without food: Nebilet tablets can generally be taken with or without food; take consistently in the same way each day as advised by your doctor.
• Elderly patients or those with renal impairment: Dose adjustment may be required; treatment should always be individualized and closely monitored by a physician.
• If you miss a dose: Take it as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose to make up for a missed tablet.
• Do not stop taking Nebilet suddenly without consulting your doctor, especially if you have ischemic heart disease, as abrupt discontinuation may worsen your condition.

Clinical Benefits:

• Effectively lowers high blood pressure by combining beta-1 receptor blockade (nebivolol) with mild diuretic action (hydrochlorothiazide).
• Helps reduce vascular resistance and promotes vasodilation through nitric oxide release, supporting better blood flow and arterial function.
• Decreases blood volume via increased urinary excretion of sodium and water, contributing to sustained blood pressure control.
• Supports long-term cardiovascular protection when used as part of a comprehensive hypertension management plan (diet, exercise, lifestyle changes, and other medications as needed).

Warnings & Contraindications:

• Prescription-only medicine. Use strictly under medical supervision.
• Contraindicated in patients with known hypersensitivity to nebivolol, hydrochlorothiazide, other sulfonamide-derived drugs, or any component of the formulation.
• Contraindicated in severe bradycardia, second or third-degree heart block (without a pacemaker), cardiogenic shock, decompensated heart failure, sick sinus syndrome, or severe peripheral circulatory disorders unless specifically allowed by a cardiologist.
• Contraindicated in anuria or severe renal impairment, severe hepatic impairment, and refractory hypokalemia or hypercalcemia.
• Use with caution in patients with diabetes, as beta-blockers may mask signs of hypoglycemia (e.g., rapid heartbeat), and thiazides may affect blood glucose levels.
• Use with caution in patients with bronchospastic diseases (e.g., asthma, COPD), thyroid disorders, gout, electrolyte imbalances (especially low potassium, sodium, or magnesium), or a history of psoriasis.
• May interact with other antihypertensives, antiarrhythmics, digitalis glycosides, NSAIDs, lithium, certain antidepressants, and other drugs. Inform your doctor about all medications and supplements you are taking.
• Consult your doctor before use if pregnant, planning pregnancy, or nursing. Beta-blockers and thiazide diuretics may not be recommended during pregnancy or breastfeeding unless clearly needed and prescribed by a specialist.
• May cause dizziness or fatigue. Avoid driving, operating machinery, or performing tasks requiring alertness until you know how the medicine affects you.
• Not intended to diagnose, treat, cure, or prevent any disease outside its approved medical indications.
• Keep out of reach of children.

Side Effects:

• Common side effects may include headache, dizziness, fatigue, slow heart rate (bradycardia), cold extremities, nausea, abdominal discomfort, or mild gastrointestinal upset.
• Due to hydrochlorothiazide, possible side effects include increased urination, electrolyte disturbances (low potassium, sodium, or magnesium), increased blood uric acid (which may trigger gout in susceptible individuals), and mild increases in blood sugar or cholesterol levels.
• Less common but serious side effects may include severe dizziness or fainting, very slow heartbeat, chest pain, shortness of breath, swelling of the face or limbs, severe skin reactions, eye pain or vision changes, or signs of severe electrolyte imbalance (muscle weakness, irregular heartbeat, confusion).
• Allergic reactions (rash, itching, swelling, severe dizziness, difficulty breathing) require immediate medical attention.
• If you experience any unusual, persistent, or severe symptoms while taking Nebilet, stop the medication only if instructed and contact your doctor or seek emergency medical care.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Product type: Prescription antihypertensive medicine (beta-blocker plus thiazide diuretic combination).
• Form: Tablet.
• Strength: Each tablet contains nebivolol 5 mg + hydrochlorothiazide 12.5 mg.
• Pack size: 14 tablets per pack.
• Intended use: Adult patients with hypertension, as prescribed by a healthcare professional.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.