Orchadexoline Drops

Orchadexoline Drops

Description:

Orchadexoline Eye Drops 5 ml is a prescription ophthalmic medication that combines a broad-spectrum antibiotic, a corticosteroid anti-inflammatory, and a vasoconstrictor decongestant to treat inflammatory and infectious eye conditions. Formulated by Orchidia, these sterile eye drops are specifically designed for short-term management of bacterial, allergic, adenoviral, and chlamydial conjunctivitis, helping to relieve redness, itching, swelling, and discharge. The formula also includes a lubricant polymer and vitamin E to support ocular surface comfort and protection during treatment.

Indications:

• Treatment of bacterial conjunctivitis (eye infection with redness, discharge, irritation).
• Management of allergic conjunctivitis with symptoms such as itching, tearing, and redness.
• Adjunctive treatment of adenoviral conjunctivitis (viral conjunctivitis) as prescribed by a doctor.
• Treatment of chlamydial conjunctivitis as part of a comprehensive therapy plan.
• Relief of ocular inflammation associated with infection or allergy, including redness, swelling, and discomfort.
• Reduction of conjunctival hyperemia (red eyes) due to the vasoconstrictor component.

Active Ingredients / Key Components:

• Chloramphenicol – 5 mg/ml (broad-spectrum antibiotic effective against many Gram-positive and Gram-negative bacteria).
• Dexamethasone sodium phosphate – 1 mg/ml (potent corticosteroid anti-inflammatory to reduce swelling, redness, and irritation).
• Tetryzoline hydrochloride – 0.25 mg/ml (vasoconstrictor to reduce eye redness and congestion).
• Hydroxypropyl methyl cellulose – 2 mg/ml (ocular lubricant to improve tear film stability and comfort).
• Alpha-tocopherol acetate (vitamin E) – 10 mg/ml (antioxidant to help protect ocular tissues from oxidative stress).
• Macrogol 400 – 8 mg/ml (humectant and lubricant to enhance ocular surface hydration).
• Other excipients: additional inactive ingredients, buffers, and stabilizers (full excipient list not available in the provided information).

Dosage & Administration / How to Use:

• Standard dose: Instill 1 drop into the affected eye(s) 4 times daily, or as directed by your ophthalmologist.
• In acute or severe cases: Your doctor may recommend up to 1 drop every hour initially, then gradually reduce frequency as symptoms improve.
• For ophthalmic use only: Use only in the eyes. Do not ingest or inject.
• Administration technique:
  • Wash hands thoroughly before use.
  • Tilt your head back and gently pull down the lower eyelid to form a small pocket.
  • Hold the bottle above the eye and instill one drop without touching the eye or eyelids with the dropper tip.
  • Close the eye gently for 1–2 minutes and press lightly on the inner corner of the eye (nasolacrimal occlusion) to reduce systemic absorption.
• If using other eye drops: Leave at least 5–10 minutes between different ophthalmic medications. Use eye ointments last.
• Duration of use: Use for the shortest duration necessary as prescribed. Prolonged use of steroid-containing eye drops should only be under strict medical supervision.
• If a dose is missed: Apply as soon as you remember, unless it is almost time for the next dose. Do not double the dose.
• Contact lens wearers: Generally, do not wear contact lenses during active eye infection or inflammation. If your doctor allows lens use, remove lenses before instillation and wait at least 15 minutes before reinsertion.

Clinical Benefits:

• Provides broad-spectrum antibacterial action to help eradicate common pathogens causing conjunctivitis.
• Reduces ocular inflammation, swelling, and discomfort through the corticosteroid component.
• Rapidly relieves eye redness and congestion thanks to the vasoconstrictor tetryzoline.
• Improves patient comfort with added lubricants and vitamin E, supporting the tear film and ocular surface.
• Combines multiple therapeutic actions (antibiotic, anti-inflammatory, decongestant, lubricant) in a single eye drop for convenient use.
• Helps restore clear, comfortable vision by controlling infection and inflammation when used as directed by a healthcare professional.

Warnings & Contraindications:

• Use only under medical supervision. This is a prescription ophthalmic medication.
• Contraindicated in patients with known hypersensitivity or allergy to chloramphenicol, dexamethasone, tetryzoline, or any component of the formulation.
• Do not use in viral infections of the cornea or conjunctiva such as herpes simplex keratitis, vaccinia, or varicella unless specifically directed by an ophthalmologist.
• Do not use in fungal or mycobacterial eye infections.
• Prolonged use of corticosteroid-containing eye drops may increase intraocular pressure, cause glaucoma, or lead to cataract formation; regular monitoring by an eye specialist is recommended for extended therapy.
• Chloramphenicol has been associated (rarely) with bone marrow suppression when used systemically; although topical ocular use has much lower risk, prolonged or repeated courses should be avoided unless clearly indicated.
• Avoid driving or operating machinery if temporary blurred vision occurs after instillation.
• To avoid contamination, do not touch the dropper tip to any surface, including the eye or hands. Close the bottle tightly after each use.
• Consult your doctor before use if pregnant or breastfeeding, or if you have glaucoma, eye hypertension, previous eye surgery, or chronic eye disease.
• Not intended to diagnose, treat, cure, or prevent any disease without medical supervision.
• Keep out of reach of children.

Side Effects:

• Common side effects: Mild transient burning or stinging, temporary blurred vision, eye irritation, or foreign body sensation after instillation.
• Less common side effects: Eye redness, allergic reactions (itching, swelling of eyelids, rash), dry eye, or increased tearing.
• Potential steroid-related effects with prolonged use: Increased intraocular pressure, glaucoma, cataract formation, delayed wound healing, or masking/worsening of ocular infections.
• Systemic effects from tetryzoline (rare, usually with excessive use): Headache, increased blood pressure, palpitations, or nervousness, especially in sensitive individuals.
• Stop use and seek immediate medical attention if you experience severe eye pain, sudden vision changes, intense redness or swelling, signs of allergic reaction, or if symptoms worsen or do not improve within a few days.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children. Do not use after the expiry date printed on the pack. Once opened, use within the period recommended by the manufacturer or your pharmacist (information not specified in the provided data; follow local pack instructions). Do not freeze.

Specifications:

• Product type: Prescription ophthalmic medicine (eye drops).
• Form: Sterile solution in dropper bottle.
• Volume: 5 ml per bottle.
• Route of administration: Topical ocular (eye) use only.
• Intended users: Adults and children as directed by a physician (age-specific guidance to be provided by the doctor).

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.