Trental Sr 400 Mg 20 Tablets

Trental Sr 400 Mg 20 Tablets

Description:

Trental Sr 400 mg is a prescription medicine containing pentoxifylline, a xanthine derivative and blood viscosity–reducing agent used to improve blood flow in patients with peripheral and cerebral circulatory disorders. It belongs to the class of phosphodiesterase inhibitors and works by improving the flexibility of red blood cells and reducing blood viscosity, thereby enhancing microcirculation and oxygen delivery to tissues, especially in ischaemic (poorly perfused) areas. Trental Sr 400 mg is formulated as sustained-release (sr) film-coated tablets to provide a controlled release of the active ingredient over time for stable therapeutic effect. It is typically used under medical supervision as part of the management of chronic vascular conditions.

Indications:

• Intermittent claudication associated with chronic occlusive peripheral arterial disease (pain, cramps, or fatigue in the legs during walking due to poor blood flow).
• Occlusive arterial diseases of the limbs to improve blood flow and reduce ischaemic symptoms.
• Cerebrovascular insufficiency (chronic disorders of brain circulation) where improved microcirculation is required, as directed by a physician.
• Circulatory disorders due to arteriosclerosis and other chronic occlusive vascular disorders.
• Trophic disorders related to impaired blood supply (e.g., certain chronic ulcers or tissue nutrition problems) as part of a comprehensive treatment plan.
• Adjunctive treatment in acute non-haemorrhagic stroke, when prescribed by a specialist, to support microcirculation.
• Other chronic occlusive vascular disorders where improving blood rheology and capillary blood flow is clinically indicated.

Active Ingredients / Key Components:

• Pentoxifylline – 400 mg per sustained-release film-coated tablet.
• Other excipients: The full list of inactive ingredients (excipients, coating agents, stabilizers) is not available in the provided information. Please refer to the official package leaflet for a complete excipient list.

Dosage & Administration / How to Use:

• Trental Sr 400 mg is for oral use only and should be taken exactly as prescribed by your doctor.
• Typical adult dosing (for guidance only – always follow your doctor’s instructions): often 400 mg 2–3 times daily in sustained-release form, depending on the severity of the condition and patient tolerance. The exact dose, frequency, and duration must be individualized by the physician.
• Tablets should be swallowed whole with a sufficient amount of water; do not crush, chew, or break the sustained-release tablets, as this may alter the release profile.
• It is generally recommended to take the tablets with or after meals to reduce the risk of gastrointestinal side effects, unless your doctor advises otherwise.
• If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to make up for a missed one.
• Use in patients with kidney or liver impairment, elderly patients, or those on anticoagulant therapy may require dose adjustment and close monitoring by a healthcare professional.
• Do not stop treatment abruptly without consulting your doctor, as the therapeutic benefits depend on continuous use.

Clinical Benefits:

• Improves blood rheology by increasing red blood cell flexibility and reducing blood viscosity, enhancing overall blood flow.
• Increases capillary blood flow to ischaemic tissues, helping to improve oxygen delivery and tissue nutrition.
• Helps reduce symptoms of intermittent claudication, such as leg pain and cramps during walking, potentially increasing walking distance and functional capacity.
• Supports management of chronic peripheral and cerebral circulatory disorders associated with arteriosclerosis and other occlusive vascular diseases.

Warnings & Contraindications:

• Use only under medical supervision. Do not use this medicine without a prescription and proper evaluation by a healthcare professional.
• Contraindicated in patients with known hypersensitivity to pentoxifylline, other xanthine derivatives (such as caffeine, theophylline), or any of the excipients.
• Generally contraindicated in patients with recent cerebral or retinal haemorrhage or any active significant bleeding disorder, unless specifically directed by a specialist.
• Use with caution in patients with a history of severe cardiac arrhythmias, recent myocardial infarction, severe coronary artery disease, or low blood pressure, as changes in blood flow may affect cardiovascular status.
• Use with caution in patients with impaired kidney or liver function; dose adjustment and close monitoring may be required.
• Concomitant use with anticoagulants (e.g., warfarin) or antiplatelet agents may increase the risk of bleeding. Prothrombin time (pt) and/or inr should be monitored regularly in patients receiving warfarin with pentoxifylline.
• May enhance the effect of antihypertensive medications, potentially leading to low blood pressure; blood pressure monitoring is recommended.
• Consult your doctor before use if you are pregnant or breastfeeding. Pentoxifylline should be used in pregnancy or lactation only if the potential benefit justifies the potential risk, as determined by the physician.
• Not recommended for use in children unless specifically prescribed by a pediatric specialist, as safety and efficacy data in pediatric populations are limited.
• Patients with a history of bleeding disorders, gastric or duodenal ulcers, recent surgery, or retinal haemorrhage should be closely monitored.
• May cause dizziness or lightheadedness in some patients; caution is advised when driving or operating machinery until you know how the medicine affects you.
• Consult your doctor before use if you have any chronic medical condition such as heart disease, stroke history, diabetes, severe hypertension or hypotension, kidney or liver disease, or if you are taking any other medications, including over-the-counter drugs and herbal supplements.
• Keep out of reach of children.

Side Effects:

• Common side effects may include nausea, vomiting, stomach discomfort, abdominal pain, diarrhoea, or bloating, especially at the start of treatment.
• Headache, dizziness, flushing, or a feeling of warmth may occur due to vasodilation and changes in blood flow.
• Less common side effects can include palpitations, chest discomfort, low blood pressure, or agitation.
• Allergic reactions such as rash, itching, urticaria, or, rarely, more severe reactions (e.g., angioedema, bronchospasm) may occur in susceptible individuals.
• Rare but serious side effects may include significant bleeding (e.g., nosebleeds, gastrointestinal bleeding, unusual bruising), severe hypotension, or arrhythmias. Seek immediate medical attention if you experience signs of serious bleeding, severe dizziness, fainting, chest pain, difficulty breathing, or swelling of the face, lips, or tongue.
• If any side effect persists, worsens, or you notice any other unusual symptoms, contact your doctor or pharmacist promptly.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children. Do not use after the expiry date printed on the pack. Store at or below the temperature specified on the package insert (specific temperature range is not available in the provided information; refer to the official leaflet).

Specifications:

• Product type: Prescription medicine – blood viscosity reducing agent / phosphodiesterase inhibitor.
• Active ingredient strength: Pentoxifylline 400 mg per sustained-release film-coated tablet.
• Form: Sustained-release film-coated tablets for oral use.
• Pack size: 20 tablets per pack.
• Intended users: Adults, as prescribed by a healthcare professional.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.