Triplixam 5/1.25/5 Mg 15 Tablets

Triplixam 5/1.25/5 Mg 15 Tablets

Description:

Triplixam 5/1.25/5 mg 15 tablets is a prescription antihypertensive medicine that combines three active ingredients: amlodipine, indapamide, and perindopril. It is used as a substitution therapy for adults with essential hypertension (high blood pressure) who are already well controlled on the same doses of these three medicines taken separately. By combining a calcium channel blocker, a thiazide-like diuretic, and an angiotensin-converting enzyme (ACE) inhibitor in one tablet, Triplixam helps lower and maintain blood pressure, supports cardiovascular health, and improves treatment convenience and adherence.

Indications:

• Treatment of essential hypertension (high blood pressure) in adults.
• Substitution therapy in patients already controlled with amlodipine + indapamide + perindopril given concurrently at the same dose level (5 mg amlodipine, 1.25 mg indapamide, 5 mg perindopril).
• Helps reduce the risk associated with uncontrolled high blood pressure, such as heart disease, stroke, and kidney damage (as part of an overall cardiovascular risk management plan prescribed by a doctor).
• May help relieve hypertension-related symptoms such as headache, dizziness, and fatigue when elevated blood pressure is controlled (symptom improvement varies by patient).

Active Ingredients / Key Components:

• Amlodipine – 5 mg per film-coated tablet (calcium channel blocker of the dihydropyridine class).
• Indapamide – 1.25 mg per film-coated tablet (thiazide-like diuretic).
• Perindopril (as perindopril arginine or perindopril erbumine – salt form may vary by market) – 5 mg per film-coated tablet (angiotensin-converting enzyme (ACE) inhibitor).
• Other excipients (tablet core and film coating) are present but detailed inactive ingredient list and concentrations are not available in the provided information.

Dosage & Administration / How to Use:

• Recommended dose (adults): One tablet of Triplixam 5/1.25/5 mg once daily.
• Timing: Preferably taken in the morning at the same time each day to maintain consistent blood levels.
• Administration: Swallow the tablet whole with a glass of water. Do not chew, crush, or break the tablet.
• Can be taken with or without food, as directed by your physician. Follow your doctor’s instructions carefully.
• Use this combination only as a substitution if you are already stabilized on separate tablets of amlodipine, indapamide, and perindopril at the same strengths.
• Do not change the dose or stop taking the medicine without consulting your doctor, even if you feel well, as high blood pressure often has no symptoms.
• If you miss a dose, take it as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
• Use only under medical supervision and according to the prescribing physician’s instructions, especially in patients with kidney, liver, or heart conditions.

Clinical Benefits:

• Triple mechanism blood pressure control: Combines a calcium channel blocker, a diuretic, and an ACE inhibitor to provide effective, multi-pathway reduction of high blood pressure.
• Improved treatment convenience and adherence: Replaces three separate tablets with one daily tablet for patients already stabilized on the same doses, which may help improve compliance.
• Supports cardiovascular protection: By controlling blood pressure, Triplixam helps reduce strain on the heart and blood vessels, contributing to long-term cardiovascular risk reduction when used as part of a comprehensive treatment plan.
• Volume and vascular resistance control: Indapamide helps reduce fluid volume, perindopril reduces vascular resistance via ACE inhibition, and amlodipine relaxes blood vessel smooth muscle, together promoting more stable blood pressure.
• Once-daily dosing: Provides 24-hour blood pressure control with a single morning dose, improving ease of use.

Warnings & Contraindications:

• Prescription only: Triplixam is a prescription antihypertensive medicine and must be used only under the supervision of a qualified healthcare professional.
• Contraindications include (not exhaustive): history of hypersensitivity or allergy to amlodipine, indapamide, perindopril, other dihydropyridines, other sulfonamides, or other ACE inhibitors; history of angioedema (swelling of the face, lips, tongue, or throat) associated with ACE inhibitor therapy; hereditary or idiopathic angioedema; severe kidney impairment; severe liver impairment; severe hypotension; cardiogenic shock; significant aortic stenosis; and during the second and third trimesters of pregnancy. Full contraindication list is not fully available in the provided information and should be checked in the official leaflet.
• Pregnancy and breastfeeding: ACE inhibitors like perindopril are generally contraindicated especially in the second and third trimesters of pregnancy due to risk to the fetus. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor immediately. Do not use without medical advice.
• Kidney and liver disease: Use with caution in patients with renal or hepatic impairment. Dose adjustment or alternative therapy may be required. Regular monitoring of kidney function and electrolytes (especially potassium) may be necessary.
• Electrolyte disturbances: Indapamide may cause changes in electrolytes (such as low potassium, low sodium). Perindopril may increase potassium levels. Your doctor may monitor electrolytes regularly.
• Low blood pressure (hypotension): May cause symptomatic hypotension, especially at the start of treatment, in dehydrated patients, or those on other blood pressure–lowering drugs. Stand up slowly from sitting or lying positions.
• Drug interactions: Inform your doctor about all medicines you are taking, including other antihypertensives, diuretics, potassium supplements, potassium-sparing diuretics, lithium, NSAIDs, and any herbal or over-the-counter products.
• Consult your doctor before use if you have heart disease, heart failure, diabetes, kidney disease, liver disease, gout, or are on a low-salt or potassium-restricted diet.
• Do not use this product to initiate therapy; it is intended only for patients already controlled on the individual components at the same dose.
• Not intended to diagnose, treat, cure, or prevent any disease outside its approved indications.
• Keep out of reach of children.

Side Effects:

• Common side effects may include: headache, dizziness, flushing, ankle or leg swelling (edema), fatigue, palpitations, cough (typically dry, due to ACE inhibitor), gastrointestinal disturbances (nausea, abdominal pain, constipation or diarrhea), and muscle cramps. Not all side effects are listed here.
• Less common but serious side effects may include: severe hypotension (very low blood pressure), angioedema (swelling of face, lips, tongue, or throat with difficulty breathing), severe allergic reactions, chest pain or worsening angina, irregular heartbeat, significant changes in kidney function, or severe electrolyte disturbances.
• Seek immediate medical attention if you experience symptoms such as swelling of the face, lips, tongue, or throat; difficulty breathing; severe dizziness or fainting; chest pain; or signs of severe allergic reaction.
• If any side effects persist, worsen, or you notice any unusual symptoms, contact your doctor or pharmacist promptly.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children. Do not use after the expiry date printed on the packaging. Store at or below the temperature recommended in the official leaflet (specific temperature range is not available in the provided information).

Specifications:

• Product type: Prescription antihypertensive medicine.
• Form: Film-coated tablets.
• Strength per tablet: amlodipine 5 mg + indapamide 1.25 mg + perindopril 5 mg.
• Pack size: 15 tablets per pack.
• Intended use: Adult patients with essential hypertension already controlled on the same doses of the three separate components.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.