Urosolvine Eff 12 Sachets

Urosolvine Eff 12 Sachets

Description:

Urosolvine Eff 12 Sachets (UROSOLVINE effervescent granules) is a prescription oral medicine formulated specifically for the management of gout and gouty arthritis, and for helping prevent uric acid urinary stones (urate lithiasis). Each sachet contains effervescent granules that are dissolved in water to provide a systemic uricosuric and anti-inflammatory effect. The combination of piperazine, colchicine, and atropine sulphate works together to increase urate solubility in urine, relieve acute gout pain and inflammation, and reduce painful smooth muscle spasm in the urinary tract. It is intended for adult use under medical supervision.

Indications:

• Acute gout attacks (acute gouty arthritis) with joint pain, redness, and swelling.
• Chronic gout and recurrent gouty arthritis to help control symptoms as part of a comprehensive treatment plan.
• Adjunctive treatment and prophylaxis against uric acid/urate urinary lithiasis (urate stones) in susceptible patients.
• Relief of pain and inflammation associated with deposition of monosodium urate crystals in joints and periarticular tissues.

Active Ingredients / Key Components:

• Atropine sulphate – concentration per sachet not specified in available information.
• Colchicine – concentration per sachet not specified in available information.
• Piperazine – concentration per sachet not specified in available information; used for its uricosuric and urate-solubilizing properties.
• Other excipients and effervescent base – full list and exact quantities , please check the product leaflet or the manufacturer’s official website. Refer to the product leaflet for complete composition.

Dosage & Administration / How to Use:

• Use only as directed by your physician. Dosage and duration depend on the severity of gout, frequency of attacks, kidney function, and overall clinical condition.
• Adults: The usual regimen is 1 sachet dissolved in a glass of water, taken orally. The exact number of sachets per day and treatment duration must be determined by the doctor.
• Pour the contents of one sachet into approximately half a glass of water, allow the granules to fully dissolve (effervesce), then drink the solution immediately.
• It may be taken with or after food to reduce potential gastrointestinal discomfort, unless your doctor advises otherwise.
• Maintain adequate fluid intake throughout the day to support uric acid excretion and help prevent stone formation, as recommended by your doctor.
• Do not exceed the prescribed dose. Do not use for longer than recommended without medical review.
• If a dose is missed, take it as soon as you remember unless it is nearly time for the next dose. Do not double the dose to make up for a missed one.

Clinical Benefits:

• Helps relieve pain and inflammation in acute gout attacks through the specific anti-inflammatory action of colchicine on neutrophils and urate crystal-induced inflammation.
• Increases the solubility of urates in urine via piperazine, supporting reduction of uric acid crystal deposition and aiding in the prevention of urate urinary stones.
• Provides adjunctive prophylaxis in chronic gout and gouty arthritis when used as part of a comprehensive uric acid–lowering strategy.
• Atropine sulphate component helps reduce smooth muscle spasm and gastrointestinal side effects associated with colchicine and piperazine, improving treatment tolerability.

Warnings & Contraindications:

• Use only under medical supervision. This is a prescription medicine for the treatment of gout and related conditions.
• Contraindicated in patients with known hypersensitivity or allergy to colchicine, piperazine, atropine sulphate, or any excipients in the formulation.
• Colchicine toxicity can be serious. Use with extreme caution in elderly patients, those with renal or hepatic impairment, or patients taking interacting medicines.
• Use with caution in patients with severe kidney disease, liver disease, gastrointestinal disorders, blood dyscrasias, or cardiac disease. Dose adjustments may be required.
• Atropine sulphate should be used carefully in patients with glaucoma, prostatic hypertrophy, urinary retention, paralytic ileus, or tachyarrhythmias.
• Piperazine should be used cautiously in patients with a history of seizures or neurological disorders.
• Drug interactions: Colchicine may interact with strong CYP3A4 inhibitors and P-gp inhibitors (such as certain macrolide antibiotics, some antifungals, some antivirals), increasing the risk of toxicity. Inform your doctor about all medicines and supplements you are taking.
• Pregnancy and breastfeeding: Use only if clearly needed and prescribed by a physician. Colchicine crosses the placenta and is excreted in breast milk; risk–benefit assessment is essential.
• May cause dizziness, blurred vision, or gastrointestinal discomfort. Avoid driving or operating machinery if you feel affected.
• Do not use in children unless specifically prescribed by a pediatric specialist.
• Consult your doctor before use if pregnant, nursing, taking other medications, or if you have medical conditions such as kidney disease, liver disease, heart disease, glaucoma, urinary retention, or blood disorders.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical supervision.
• Keep out of reach of children.

Side Effects:

• Common side effects may include nausea, vomiting, abdominal pain, diarrhea, and mild gastrointestinal discomfort, especially at higher doses of colchicine.
• Other possible effects: headache, dizziness, dry mouth, blurred vision, constipation, or urinary retention (related to atropine), and mild skin rash or hypersensitivity reactions.
• Serious side effects (seek immediate medical attention): severe or persistent vomiting or diarrhea, muscle weakness, numbness or tingling, unusual bleeding or bruising, signs of infection (fever, sore throat), severe abdominal pain, jaundice (yellowing of skin or eyes), palpitations, or difficulty urinating.
• If you experience any unexpected or severe symptoms, stop taking the medicine and contact your doctor or emergency services immediately.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed and sachets in their original packaging to protect from moisture. Do not store above the temperature stated on the pack (exact temperature not specified in available information; follow pack instructions). Keep out of reach of children.

Specifications:

• Product form: Effervescent granules in sachets for oral solution.
• Pack size: 12 sachets per pack.
• Intended use: Prescription medicine for gout, gouty arthritis, and prophylaxis of urate urinary lithiasis in adults, as directed by a physician.
• Active ingredients: Atropine sulphate, colchicine, piperazine (exact strengths per sachet not available in the provided information; refer to product leaflet).

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.