X-Tension Plus - 300/12.5 Mg 28 Tablets

X-Tension Plus - 300/12.5 mg 28 Tablets

Description:

X-Tension Plus 300/12.5 mg is a prescription antihypertensive medicine combining an angiotensin II receptor blocker (ARB) with a thiazide diuretic. Each scored tablet contains irbesartan and hydrochlorothiazide, working together to lower high blood pressure, improve blood vessel relaxation, and promote gentle diuresis. This fixed-dose combination is indicated for adults who require dual therapy to achieve optimal blood pressure control and reduce cardiovascular risk under medical supervision.

Indications:

• Treatment of essential (primary) hypertension in adults.
• Patients whose blood pressure is not adequately controlled with irbesartan or hydrochlorothiazide alone.
• Management of high blood pressure to help reduce the risk of complications such as stroke, heart attack, and kidney damage, as assessed by a physician.
• May be used as replacement therapy in patients already stabilized on the individual components at the same doses.

Active Ingredients / Key Components:

• Irbesartan – 300 mg per tablet (angiotensin II receptor blocker – ARB).
• Hydrochlorothiazide – 12.5 mg per tablet (thiazide diuretic).
• Excipients: Information on inactive ingredients (e.g., fillers, binders, coloring agents) is not available in the provided data. Please refer to the official package leaflet for the full excipient list.

Dosage & Administration / How to Use:

• Use only as prescribed by a physician experienced in the management of hypertension.
• Typical adult dose: 1 tablet (300/12.5 mg) once daily, preferably at the same time each day. The exact dose and duration are determined by your doctor.
• Can be taken with or without food. Swallow the tablet whole with a glass of water; do not crush or chew unless advised by your doctor.
• If a dose is missed, take it as soon as you remember on the same day. If it is almost time for the next dose, skip the missed dose and resume the regular schedule. Do not double the dose.
• Regular monitoring of blood pressure, kidney function, and electrolytes (especially potassium, sodium, and magnesium) is recommended during treatment.
• Do not stop taking X-Tension Plus suddenly without consulting your doctor, as uncontrolled blood pressure may increase cardiovascular risk.

Clinical Benefits:

• Provides effective blood pressure reduction by combining two complementary mechanisms: vasodilation via ARB action and mild diuresis via thiazide diuretic.
• Helps reduce total peripheral resistance and plasma volume, contributing to sustained blood pressure control.
• Supports long-term cardiovascular protection by helping lower the risk of complications associated with uncontrolled hypertension (e.g., stroke, heart attack), when used as part of overall risk management.
• Convenient once-daily fixed-dose combination improves treatment adherence compared to taking separate tablets.

Warnings & Contraindications:

• Contraindicated in patients with known hypersensitivity to irbesartan, hydrochlorothiazide, other sulfonamide-derived drugs, or any component of the product.
• Contraindicated during pregnancy, especially in the second and third trimesters, due to risk of fetal toxicity and death. If pregnancy is detected, discontinue immediately and contact your doctor.
• Contraindicated in severe renal impairment, anuria, or severe hepatic impairment, unless specifically evaluated and supervised by a specialist.
• Use with caution in patients with kidney disease, liver disease, heart failure, coronary artery disease, diabetes, gout, or a history of electrolyte imbalance.
• Hydrochlorothiazide may cause electrolyte disturbances (hypokalemia, hyponatremia, hypomagnesemia) and may increase uric acid and blood glucose levels; monitoring is required, especially in diabetic or gout patients.
• May interact with other medicines such as lithium, other antihypertensives, potassium supplements, potassium-sparing diuretics, NSAIDs, and certain antidiabetic drugs. Inform your doctor about all medications and supplements you are taking.
• May cause dizziness or fatigue, especially at the start of treatment or when the dose is increased. Avoid driving or operating machinery until you know how the medicine affects you.
• Consult your doctor before use if pregnant, nursing, planning pregnancy, taking other medications, or if you have medical conditions such as kidney disease, liver disease, heart failure, diabetes, gout, or electrolyte imbalance.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical supervision.
• Keep out of reach of children.

Side Effects:

• Common side effects may include dizziness, headache, fatigue, nausea, mild gastrointestinal discomfort, or increased urination due to the diuretic component.
• Possible laboratory changes: decreased potassium, sodium, or magnesium; increased uric acid; slight increases in blood glucose or blood lipids; changes in kidney function tests.
• Less common but serious side effects may include severe hypotension (very low blood pressure), kidney impairment, severe electrolyte imbalance, allergic reactions (rash, itching, swelling, difficulty breathing), or eye pain/vision changes suggestive of acute angle-closure glaucoma associated with sulfonamide drugs.
• Stop the medicine and seek immediate medical attention if you experience severe dizziness or fainting, difficulty breathing, swelling of the face or throat, severe abdominal pain, chest pain, or sudden changes in vision.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Product type: Prescription antihypertensive medicine (angiotensin II receptor blocker + thiazide diuretic).
• Strength: 300 mg irbesartan / 12.5 mg hydrochlorothiazide per tablet.
• Form: Scored tablets for oral use.
• Pack size: 28 tablets per pack.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.