Zyrovazet 10/20 Mg 30 Tablets

Zyrovazet 10/20 Mg 30 Tablets

Description:

Zyrovazet 10/20 mg 30 tablets is a prescription oral lipid-lowering medicine that combines ezetimibe and rosuvastatin to help reduce high cholesterol and triglyceride levels. It belongs to the class of anti-hyperlipidemic agents and is used as part of a comprehensive cardiovascular risk reduction plan, including a cholesterol-lowering diet, exercise, and lifestyle modification. By targeting both intestinal cholesterol absorption and hepatic cholesterol synthesis, Zyrovazet provides dual-action control of elevated low-density lipoprotein (ldl) cholesterol, helping to protect heart and blood vessels and support long-term cardiovascular health.

Indications:

• Primary hypercholesterolemia (high cholesterol), including heterozygous familial and non-familial hypercholesterolemia, as an adjunct to diet when response to diet and other non-pharmacological measures is inadequate.
• Mixed dyslipidemia (elevated ldl cholesterol, total cholesterol, triglycerides, and/or low high-density lipoprotein (hdl) cholesterol) in adults.
• Homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering treatments (such as ldl apheresis) or when such treatments are not available or not suitable.
• Patients requiring additional ldl cholesterol reduction when already on statin therapy and not achieving target lipid levels.
• Reduction of cardiovascular risk in patients with multiple risk factors where lowering ldl cholesterol is indicated as part of prevention of atherosclerotic cardiovascular disease (such as coronary artery disease, heart attack, and stroke).

Active Ingredients / Key Components:

• Ezetimibe – 10 mg per film-coated tablet (cholesterol absorption inhibitor).
• Rosuvastatin – 20 mg per film-coated tablet (hmg-coa reductase inhibitor / statin).
• Other excipients: The full list of inactive ingredients (excipients, colorants, coating agents, preservatives) is not available in the provided information. Please refer to the official package leaflet for a complete ingredient list.

Dosage & Administration / How to Use:

• Dosage must always be individualized and determined by the prescribing physician based on baseline cholesterol levels, treatment goals, patient response, and clinical guidelines.
• Usual adult dose for this strength: one tablet of Zyrovazet 10/20 mg once daily, or as directed by your doctor.
• Route of administration: oral use only. Swallow the tablet whole with a glass of water. Do not crush or chew.
• Can be taken with or without food, preferably at the same time each day to maintain consistent blood levels.
• Continue following a cholesterol-lowering diet and lifestyle (weight control, physical activity, smoking cessation) during treatment.
• If you are taking bile acid sequestrants (such as cholestyramine), take Zyrovazet at least 2 hours before or 4 hours after those medicines to avoid reduced absorption.
• If you miss a dose, take it as soon as you remember on the same day. If it is almost time for the next dose, skip the missed dose and resume your regular schedule. Do not double the dose to make up for a missed tablet.
• Do not stop taking Zyrovazet without consulting your doctor, as cholesterol levels may rise again, increasing cardiovascular risk.

Clinical Benefits:

• Provides dual mechanism of action by inhibiting intestinal cholesterol absorption (ezetimibe) and reducing hepatic cholesterol synthesis (rosuvastatin), leading to more effective ldl cholesterol reduction.
• Helps significantly lower total cholesterol, ldl cholesterol ("bad" cholesterol), and non-hdl cholesterol, supporting better lipid profile control.
• Can reduce elevated triglyceride levels and may modestly increase hdl cholesterol ("good" cholesterol) in patients with mixed dyslipidemia.
• Supports reduction of atherosclerotic plaque progression and may lower the risk of cardiovascular events when used as part of a comprehensive risk management plan.
• Convenient fixed-dose combination in a single daily tablet, which may improve treatment adherence compared to taking separate ezetimibe and statin tablets.

Warnings & Contraindications:

• Contraindicated in patients with known hypersensitivity to ezetimibe, rosuvastatin, or any component of the formulation.
• Contraindicated in patients with active liver disease or unexplained persistent elevations in serum transaminases.
• Contraindicated during pregnancy and breastfeeding, as statins may harm the fetus or nursing infant. Women of childbearing potential should use effective contraception during treatment.
• Use with caution in patients with a history of liver impairment, heavy alcohol use, or those taking other medicines that affect liver function. Regular liver function tests may be required.
• Use with caution in patients with kidney impairment, hypothyroidism, personal or family history of hereditary muscle disorders, or previous muscle toxicity with statins or fibrates.
• May increase risk of myopathy and rhabdomyolysis, especially at higher statin doses or when combined with certain drugs (e.g., some antivirals, fibrates, cyclosporine). Inform your doctor about all medicines and supplements you are taking.
• Stop treatment and seek medical advice immediately if you experience unexplained muscle pain, tenderness, weakness, or cramps, particularly if accompanied by malaise or fever.
• Consult your doctor before use if you have liver disease, kidney disease, thyroid disorders, diabetes, uncontrolled seizures, or a history of stroke.
• May slightly increase blood sugar levels; diabetic patients should monitor glucose regularly.
• Avoid excessive alcohol consumption during treatment, as this may increase the risk of liver side effects.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical supervision. Use only under the guidance of a licensed healthcare professional.
• Keep out of reach of children. Accidental ingestion by children requires immediate medical attention.

Side Effects:

• Common side effects may include headache, dizziness, abdominal pain, nausea, constipation, diarrhea, flatulence, fatigue, or muscle aches. These are usually mild and transient.
• Less common side effects can include rash, itching, elevated liver enzymes, joint pain, or sleep disturbances.
• Serious but rare side effects include myopathy, rhabdomyolysis (severe muscle breakdown with muscle pain, weakness, dark urine), severe liver injury (yellowing of skin or eyes, dark urine, persistent nausea), or allergic reactions (swelling of face, lips, tongue, difficulty breathing).
• Seek immediate medical attention if you develop severe muscle pain, unexplained muscle weakness, chest pain, shortness of breath, sudden severe abdominal pain, signs of liver problems, or symptoms of a serious allergic reaction.
• This is not a complete list of side effects. Refer to the official patient information leaflet and consult your doctor or pharmacist for more details.

Storage Instructions:

Store in a cool, dry place away from direct sunlight and moisture. Keep the tablets in their original blister pack and outer carton to protect from light. Do not store above 30°c unless otherwise specified on the package. Keep container tightly closed and out of reach of children. Do not use after the expiry date printed on the pack.

Specifications:

• Product type: prescription lipid-lowering medicine (anti-hyperlipidemic).
• Active ingredients: ezetimibe 10 mg + rosuvastatin 20 mg per film-coated tablet.
• Form: film-coated tablets for oral use.
• Pack size: 30 tablets per pack.
• Intended users: adults as prescribed by a healthcare professional.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.