Avara 10 Mg Tablets

Avara 10 Mg Tablets

Description:

Avara 10 mg tablets are a prescription disease-modifying antirheumatic drug (DMARD) containing leflunomide, used to manage chronic inflammatory joint diseases such as rheumatoid arthritis and psoriatic arthritis. As an immunomodulatory medicine, Avara helps reduce joint pain, swelling, and stiffness, and slows structural joint damage by inhibiting pyrimidine synthesis in activated lymphocytes. It is intended for adult patients and must be used under the supervision of a rheumatologist or qualified healthcare professional.

Indications:

• Treatment of active rheumatoid arthritis in adults to reduce signs and symptoms such as joint pain, swelling, morning stiffness, and reduced mobility.
• Treatment of active psoriatic arthritis in adults to improve joint function and decrease inflammatory symptoms.
• Helps slow progression of joint damage associated with chronic inflammatory arthritis when used as a long-term disease-modifying therapy.

Active Ingredients / Key Components:

• Leflunomide – 10 mg per film-coated tablet.
• Excipients: The full list of inactive ingredients (excipients, colorants, preservatives) is not available in the provided information. Please refer to the official package leaflet for complete excipient details.

Dosage & Administration / How to Use:

• Avara 10 mg tablets are for oral use only and are intended for adults.
• Tablets should be swallowed whole with water and can usually be taken with or without food, preferably at the same time each day.
• Typical dosing in rheumatoid arthritis and psoriatic arthritis often starts with a loading dose followed by a maintenance dose; however, the exact dose (including whether a loading dose is needed) must be determined individually by the treating physician based on disease severity, concomitant therapy, and patient tolerance.
• Do not exceed the dose prescribed by your doctor. Do not stop or change the dose without medical advice, as disease flare or adverse effects may occur.
• If you miss a dose, take it as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose to make up for a missed tablet.
• Regular monitoring of liver function tests, blood counts, and blood pressure is usually required during treatment with leflunomide.

Clinical Benefits:

• Helps reduce joint pain, swelling, and tenderness in rheumatoid arthritis and psoriatic arthritis.
• Improves joint mobility and physical function, supporting better daily activity and quality of life.
• Acts as a disease-modifying antirheumatic drug (DMARD) to slow progression of structural joint damage.
• Provides immunomodulatory and anti-inflammatory effects by inhibiting dihydroorotate dehydrogenase, reducing proliferation of activated lymphocytes involved in autoimmune joint inflammation.

Warnings & Contraindications:

• Contraindicated in patients with known hypersensitivity to leflunomide or any component of the formulation.
• Contraindicated in patients with severe immunodeficiency, significant bone marrow dysfunction, or severe infections.
• Contraindicated in patients with severe hepatic impairment or significantly elevated liver enzymes.
• Contraindicated in pregnant women and women of childbearing potential not using reliable contraception, due to risk of serious fetal harm. Leflunomide is teratogenic.
• Men planning to father a child should discuss washout procedures with their doctor before conception attempts.
• Use with caution in patients with a history of liver disease, alcohol abuse, renal impairment, uncontrolled hypertension, or hematologic disorders.
• Concomitant use with other hepatotoxic drugs (such as certain antirheumatics, methotrexate, or high-dose paracetamol) may increase the risk of liver damage and requires close monitoring.
• Drug interactions: co-administration with cholestyramine or activated charcoal can rapidly and significantly decrease leflunomide activity (used for washout in toxicity or pregnancy planning). Co-administration with rifampicin may increase leflunomide plasma levels. Use with non-steroidal anti-inflammatory drugs (nsaids) may increase the free fraction of diclofenac and ibuprofen; clinical monitoring is advised.
• Regular liver function tests, complete blood counts, and blood pressure monitoring are recommended throughout therapy.
• Consult your doctor before use if pregnant, nursing, planning pregnancy, taking other medications, or if you have liver disease, kidney disease, infections, hypertension, or blood disorders.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical supervision.
• Keep out of reach of children.

Side Effects:

• Common side effects may include gastrointestinal disturbances (diarrhea, nausea, abdominal pain), headache, dizziness, weight loss, and mild hair thinning.
• Laboratory abnormalities may include elevated liver enzymes, mild decreases in white blood cells or platelets, and increased blood pressure.
• Less common but serious side effects can include severe liver injury, severe infections, significant bone marrow suppression, allergic reactions, severe skin reactions, or peripheral neuropathy.
• Stop the medicine and seek immediate medical attention if you experience symptoms such as persistent nausea or vomiting, dark urine, yellowing of the skin or eyes (jaundice), unexplained bruising or bleeding, severe abdominal pain, shortness of breath, persistent fever, severe rash, or signs of infection.
• Report any unusual or bothersome symptoms to your doctor promptly. Your physician may adjust the dose, perform a washout procedure, or discontinue treatment if necessary.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Form: Film-coated tablet.
• Strength: 10 mg leflunomide per tablet.
• Pack size: 30 film-coated tablets per pack (as commonly available; confirm exact pack size on the package).
• Intended use: Prescription medicine for adult patients with rheumatoid arthritis or psoriatic arthritis, under medical supervision.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.