Avara 20 Mg 30 Tablets

Avara 20 Mg 30 Tablets

Description:

Avara 20 mg 30 tablets is a prescription oral medicine containing leflunomide, a disease-modifying antirheumatic drug (DMARD) used for the long-term management of autoimmune joint diseases. It works as an immunomodulatory and anti-inflammatory agent by inhibiting pyrimidine synthesis, helping to slow disease progression, reduce joint damage, and relieve symptoms such as pain, swelling, and stiffness in rheumatoid arthritis and psoriatic arthritis. Avara 20 mg is intended for adult patients under the supervision of a rheumatologist or qualified healthcare professional.

Indications:

• Management of active rheumatoid arthritis in adults, including reduction of joint pain, swelling, and morning stiffness, and slowing structural joint damage.
• Treatment of active psoriatic arthritis in adults to improve joint function, reduce inflammation, and help maintain mobility.
• Used as a disease-modifying therapy (DMARD) when conventional symptomatic treatments such as non-steroidal anti-inflammatory drugs (nsaids) are insufficient.

Active Ingredients / Key Components:

• Leflunomide – 20 mg per film-coated tablet.
• Excipients: The full list of inactive ingredients (such as tablet core and coating components, binders, and coloring agents) is not available in the provided information. Please refer to the official package leaflet for a complete excipient list.

Dosage & Administration / How to Use:

• Avara 20 mg is for oral use only and should be taken exactly as prescribed by your doctor.
• Usual adult dosing for rheumatoid arthritis and psoriatic arthritis often starts with a loading dose followed by a maintenance dose (commonly 20 mg once daily), but the exact regimen must be determined by the treating physician. Specific loading dose information is not provided here; follow your doctor’s instructions and the package insert.
• Tablets may be taken with or without food, swallowed whole with a glass of water. Do not crush or chew the tablets unless advised by your doctor.
• Take the medicine at the same time each day to maintain a consistent level in your body.
• Do not change the dose, skip doses, or stop treatment without consulting your doctor, as leflunomide has a long half-life and requires medical supervision for discontinuation or washout procedures.
• If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not double the dose to make up for a missed tablet.
• Regular monitoring of liver function tests, blood counts, and blood pressure is usually required during treatment. Attend all scheduled follow-up appointments and laboratory tests.

Clinical Benefits:

• Helps slow the progression of rheumatoid arthritis and psoriatic arthritis by acting as a disease-modifying antirheumatic drug (DMARD).
• Reduces joint pain, tenderness, swelling, and stiffness, improving daily comfort and quality of life.
• Improves joint mobility and physical function, supporting better movement and ability to perform everyday activities.
• Provides sustained immunomodulatory and anti-inflammatory effects through inhibition of dihydroorotate dehydrogenase (dhodh), reducing overactive immune responses in autoimmune joint disease.

Warnings & Contraindications:

• Contraindicated in patients with known hypersensitivity to leflunomide or any component of the formulation.
• Contraindicated in patients with severe liver impairment or significant pre-existing liver disease due to risk of serious hepatotoxicity.
• Contraindicated in pregnant women and women of childbearing potential not using reliable contraception, as leflunomide may cause fetal harm (teratogenic). It is also not recommended in breastfeeding women.
• Use with extreme caution in patients with a history of chronic infections, severe immunodeficiency, bone marrow suppression, or severe uncontrolled infections.
• Co-administration with hepatotoxic drugs (such as certain methotrexate regimens or other liver-toxic medicines) may increase the risk of liver damage and should be carefully monitored or avoided.
• Cholestyramine or activated charcoal: co-administration can rapidly and significantly decrease leflunomide plasma levels and activity (used as a washout procedure when rapid elimination is needed).
• Rifampicin: co-administration may increase leflunomide plasma levels and the risk of adverse effects; close monitoring is required.
• Concomitant use with nsaids may increase the free fraction of some agents (e.g., diclofenac, ibuprofen); clinical monitoring is recommended.
• Regular liver function tests and complete blood counts are recommended before starting therapy and periodically during treatment.
• Consult your doctor before use if you have liver disease, kidney disease, chronic infections, hypertension, history of blood disorders, or are taking other immunosuppressive or hepatotoxic medications.
• Do not receive live vaccines during treatment and for a period after stopping therapy without medical advice, as immune response may be altered.
• Avoid alcohol or limit intake, as concurrent alcohol use may increase the risk of liver toxicity.
• Consult your doctor before use if pregnant, nursing, planning pregnancy, taking medications, or have medical conditions such as liver disease, kidney disease, hypertension, or immune disorders.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical supervision.
• Keep out of reach of children.

Side Effects:

• Common side effects may include gastrointestinal disturbances (nausea, diarrhea, abdominal pain), mild hair thinning or hair loss, weight loss, headache, dizziness, and mild increases in blood pressure.
• Liver-related side effects such as elevated liver enzymes may occur; your doctor will monitor liver function regularly. Contact your doctor immediately if you notice yellowing of the skin or eyes, dark urine, persistent nausea, or unusual fatigue.
• Hematologic effects such as decreased white blood cells, red blood cells, or platelets may occur, increasing the risk of infections, anemia, or bleeding. Report signs of infection (fever, sore throat), unusual bruising, or bleeding promptly.
• Allergic or hypersensitivity reactions including rash, itching, or more severe skin reactions may occur. Seek urgent medical attention if you develop widespread rash, blistering, or difficulty breathing.
• Serious but less common side effects may include severe infections, severe liver injury, interstitial lung disease, or severe skin reactions. Immediate medical attention is required if severe symptoms develop.
• If any side effects become severe, persistent, or concerning, stop taking the medicine and contact your doctor or pharmacist immediately.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Product type: Prescription medicine – disease-modifying antirheumatic drug (DMARD).
• Active ingredient strength: leflunomide 20 mg per film-coated tablet.
• Form: Film-coated tablets for oral administration.
• Pack size: 30 tablets per pack.
• Intended use: Adult patients with rheumatoid arthritis or psoriatic arthritis under medical supervision.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.