Coaprovel 300/25 Mg 14 Tablets

Coaprovel 300/25 Mg 14 Tablets

Description:

Coaprovel 300/25 mg 14 tablets is a prescription antihypertensive medicine that combines two active ingredients, irbesartan and hydrochlorothiazide, to effectively lower high blood pressure and help protect cardiovascular health. It belongs to the class of angiotensin II receptor blockers (ARB) combined with a thiazide diuretic, offering dual action: relaxing blood vessels and promoting gentle diuresis to reduce blood volume. Coaprovel is used in adults for the management of essential hypertension, particularly when monotherapy is insufficient, and is commonly prescribed as part of long-term blood pressure control and heart disease prevention plans.

Indications:

• Treatment of essential hypertension (high blood pressure) in adults.
• Indicated in patients whose blood pressure is not adequately controlled by irbesartan or hydrochlorothiazide alone.
• Helps reduce the risk of cardiovascular complications associated with uncontrolled hypertension, such as stroke, heart attack, and heart failure (as part of an overall risk reduction strategy prescribed by a physician).
• May be used in patients requiring combination therapy to achieve target blood pressure levels.

Active Ingredients / Key Components:

• Irbesartan – 300 mg per tablet (angiotensin II receptor blocker – ARB).
• Hydrochlorothiazide – 25 mg per tablet (thiazide diuretic).
• Other tablet excipients (such as fillers, binders, coating agents, and preservatives) are present but specific names and concentrations , please check the product leaflet or the manufacturer’s official website.

Dosage & Administration / How to Use:

• Coaprovel 300/25 mg is for oral use only and should be taken exactly as prescribed by your physician.
• Usual adult dose: 1 tablet once daily, preferably at the same time each day. The exact dose and duration are determined by the doctor based on blood pressure response and clinical condition.
• Tablets may be taken with or without food. Swallow the tablet whole with a glass of water; do not crush or chew unless your doctor advises otherwise.
• If a dose is missed, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to make up for a missed dose.
• Continue taking Coaprovel even if you feel well, as high blood pressure often has no symptoms. Do not stop treatment without consulting your doctor.
• Regular monitoring of blood pressure, kidney function, and electrolytes (especially potassium and sodium) is recommended during treatment.

Clinical Benefits:

• Provides effective blood pressure reduction through dual mechanism: vasodilation via irbesartan and mild diuresis via hydrochlorothiazide.
• Helps lower the risk of serious cardiovascular events associated with uncontrolled hypertension, when used as part of a comprehensive treatment plan.
• Improves blood vessel relaxation and decreases total peripheral resistance, supporting healthier blood circulation.
• Convenient once-daily fixed-dose combination improves treatment adherence compared to taking two separate medicines.
• Hydrochlorothiazide component promotes excretion of excess sodium and water, helping to reduce plasma volume and blood pressure.

Warnings & Contraindications:

• Contraindicated in patients with known hypersensitivity to irbesartan, hydrochlorothiazide, other sulfonamide-derived drugs, or any component of the formulation.
• Contraindicated in severe renal impairment, anuria (inability to produce urine), severe hepatic impairment, and refractory hypokalemia or hypercalcemia.
• Do not use during the second and third trimesters of pregnancy. Use in the first trimester is not recommended. ARBs can cause injury and death to the developing fetus.
• Not recommended during breastfeeding; consult your doctor for safer alternatives.
• Use with caution in patients with kidney disease, liver disease, heart failure, diabetes, gout, systemic lupus erythematosus, or electrolyte imbalances (low potassium, low sodium, high calcium).
• May cause dizziness or fatigue, especially at the start of treatment or when the dose is increased. Avoid driving or operating machinery until you know how the medicine affects you.
• Concomitant use with other medicines that affect the renin–angiotensin–aldosterone system (ACE inhibitors, other ARBs, aliskiren) or potassium-sparing diuretics, potassium supplements, or lithium requires close medical supervision.
• Alcohol may enhance the blood pressure-lowering effect and increase dizziness; limit alcohol intake.
• Consult your doctor before use if pregnant, nursing, taking other medications, or have medical conditions such as kidney disease, liver disease, diabetes, heart failure, gout, or autoimmune disease.
• Keep out of reach of children.

Side Effects:

• Common side effects may include dizziness, headache, fatigue, nausea, abdominal discomfort, and increased urination due to the diuretic component.
• Possible changes in laboratory values: low potassium (hypokalemia), low sodium (hyponatremia), increased uric acid (which may trigger gout), slight increases in blood urea or creatinine, and changes in blood glucose, especially in diabetic patients.
• Less common but serious side effects may include severe allergic reactions (rash, itching, swelling of face/lips/tongue, difficulty breathing), severe dizziness or fainting, muscle weakness, irregular heartbeat, or signs of kidney problems (reduced urine output, swelling of legs or ankles).
• Stop taking the medicine and seek immediate medical attention if you experience signs of angioedema (swelling of the face, lips, tongue, or throat), severe skin reactions, or persistent severe dizziness or fainting.
• Report any unusual or persistent side effects to your doctor or pharmacist promptly.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Product type: Prescription antihypertensive medicine (angiotensin II receptor blocker + thiazide diuretic).
• Form: Tablets for oral use.
• Strength: 300 mg irbesartan + 25 mg hydrochlorothiazide per tablet.
• Pack size: 14 tablets per pack.
• Intended use: Adult patients for the management of essential hypertension under medical supervision.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.