Coveram 10/5 Mg 15 Tablets

Coveram 10/5 Mg 15 Tablets

Description:

Coveram 10/5 mg 15 tablets is a prescription combination antihypertensive medicine containing amlodipine and perindopril, used for long‑term control of high blood pressure and cardiovascular risk reduction. It combines a calcium channel blocker (amlodipine) with an angiotensin-converting enzyme (ACE) inhibitor (perindopril) in a single daily tablet to improve blood pressure control, protect the heart and blood vessels, and help prevent cardiovascular events in high‑risk patients. Manufactured by Servier, Coveram is commonly prescribed for adults with essential hypertension, heart failure, and stable coronary artery disease, especially after myocardial infarction.

Indications:

• Treatment of mild to moderate essential hypertension (high blood pressure) in adults.
• Management of mild to moderate congestive heart failure, as part of a comprehensive treatment plan prescribed by a cardiologist.
• Reduction of cardiovascular risk in patients with hypertension and/or stable coronary artery disease.
• Secondary prevention after myocardial infarction in patients with stable coronary disease to help reduce the risk of future cardiovascular events.
• Control of blood pressure in patients who require combination therapy with amlodipine and perindopril and are stabilized on the individual components at equivalent doses.

Active Ingredients / Key Components:

• Amlodipine – 10 mg per tablet (dihydropyridine calcium channel blocker; exact excipient composition and full formula , please check the product leaflet or the manufacturer’s official website).
• Perindopril (as perindopril arginine or perindopril erbumine depending on market formulation) – 5 mg per tablet (ACE inhibitor; specific salt form and excipient details , please check the product leaflet or the manufacturer’s official website).
• Inactive ingredients (excipients) – information on the full list of excipients and their concentrations is not available in the provided information. Refer to the official package leaflet for complete details.

Dosage & Administration / How to Use:

• Coveram 10/5 mg is intended for adults only and must be used exactly as prescribed by a physician.
• Usual dose: one tablet once daily, preferably taken at the same time each morning.
• Administration: Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.
• With or without food: It is generally recommended to take perindopril-containing products before a meal; follow your doctor’s specific instructions regarding food intake.
• Do not change the dose, split tablets, or discontinue treatment without consulting your doctor, even if you feel well, as hypertension often has no symptoms.
• If a dose is missed: Take it as soon as you remember on the same day. If it is almost time for the next dose, skip the missed dose and resume the regular schedule. Do not take a double dose to make up for a missed one.
• Duration of use: Long‑term, chronic therapy as directed by your physician to control blood pressure and reduce cardiovascular risk.
• Regular monitoring: Blood pressure, kidney function, and blood electrolytes (especially potassium) should be monitored periodically during treatment.

Clinical Benefits:

• Provides effective 24‑hour blood pressure control by combining two complementary antihypertensive mechanisms (calcium channel blockade and ACE inhibition).
• Reduces peripheral vascular resistance and improves arterial dilation, thereby lowering blood pressure and decreasing cardiac workload.
• Helps reduce the risk of cardiovascular events such as heart attack and stroke in patients with hypertension and stable coronary artery disease.
• Improves symptoms and hemodynamics in mild to moderate congestive heart failure as part of a comprehensive treatment regimen.
• Enhances patient adherence by combining two active ingredients in a single once‑daily tablet, simplifying treatment regimens.

Warnings & Contraindications:

• Contraindicated in patients with known hypersensitivity or allergy to amlodipine, other dihydropyridine calcium channel blockers, perindopril, other ACE inhibitors, or any of the excipients.
• Contraindicated in patients with a history of angioedema (swelling of the face, lips, tongue, or throat) associated with previous ACE inhibitor therapy or hereditary/idiopathic angioedema.
• Contraindicated during the second and third trimesters of pregnancy; ACE inhibitors can cause serious harm to the fetus. Use in the first trimester is not recommended.
• Contraindicated in severe hypotension, cardiogenic shock, or hemodynamically unstable heart failure after acute myocardial infarction.
• Use with caution in patients with renal impairment, renal artery stenosis, liver impairment, aortic stenosis, hypertrophic cardiomyopathy, or in those on diuretics or potassium‑sparing medicines.
• May cause symptomatic hypotension, especially in volume‑depleted patients (e.g., on high‑dose diuretics, low‑salt diet, vomiting, or diarrhea). Initiation and dose adjustments should be supervised by a physician.
• Hyperkalemia (high potassium levels) may occur, particularly in patients with renal impairment, diabetes, or those taking potassium supplements, potassium‑sparing diuretics, or other medicines affecting the renin‑angiotensin‑aldosterone system.
• May cause dizziness, fatigue, or visual disturbances; caution is advised when driving or operating machinery until you know how the medicine affects you.
• Alcohol may enhance the blood pressure‑lowering effect and increase the risk of dizziness or fainting.
• Consult your doctor before use if pregnant, planning pregnancy, or nursing. ACE inhibitors are not recommended in breastfeeding; your doctor may choose an alternative medicine.
• Consult your doctor before use if you are taking other medications, especially diuretics, other antihypertensives, potassium supplements, lithium, NSAIDs, or medicines for heart disease or diabetes.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical supervision and prescription.
• Keep out of reach of children.

Side Effects:

• Common side effects may include dizziness, headache, flushing, palpitations, ankle or leg swelling (peripheral edema), fatigue, nausea, abdominal discomfort, or cough (typically dry, persistent ACE inhibitor–related cough).
• Less common side effects may include low blood pressure (hypotension), muscle cramps, rash, pruritus, or changes in taste.
• Serious but rare side effects include angioedema (swelling of face, lips, tongue, or throat), severe hypotension, chest pain, irregular heartbeat, jaundice or signs of liver dysfunction, and significant changes in kidney function.
• Stop taking the medicine and seek immediate medical attention if you experience difficulty breathing, swelling of the face or throat, severe dizziness or fainting, chest pain, or signs of an allergic reaction.
• Report any persistent, bothersome, or unexpected side effects to your doctor or pharmacist.

Storage Instructions:

Store in a cool, dry place away from direct sunlight and moisture. Keep the blister pack in the outer carton to protect from light. Do not store above the temperature specified on the package (typically below 25–30°c; refer to the official pack for exact limit). Keep container tightly closed if repackaged. Keep out of reach of children.

Specifications:

• Product type: Prescription antihypertensive medicine (combination ACE inhibitor and calcium channel blocker).
• Strength: 10 mg amlodipine + 5 mg perindopril per tablet.
• Form: Tablet for oral use.
• Pack size: 15 tablets per pack.
• Intended users: Adult patients as prescribed by a healthcare professional.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.