Diglifloz Plus 5/1000 Mg 30 Tablets

Diglifloz Plus 5/1000 Mg 30 Tablets

Description:

Diglifloz Plus 5/1000 mg is an oral antidiabetic prescription medicine that combines dapagliflozin (an SGLT2 inhibitor) and metformin (a biguanide) in one film-coated tablet. It is used as part of a comprehensive diabetes care plan, including diet and exercise, to help control blood glucose levels in adults with type 2 diabetes mellitus. By reducing glucose reabsorption in the kidneys and decreasing hepatic glucose production while improving insulin sensitivity, Diglifloz Plus 5/1000 mg helps achieve better long-term glycemic control and supports diabetes-related health prevention.

Indications:

• Adjunct to diet and exercise for the treatment and management of type 2 diabetes mellitus in adults.
• Improvement of glycemic control when metformin alone, or metformin in combination with other antidiabetic agents, is insufficient.
• Reduction of elevated fasting and postprandial blood glucose levels.
• Helps lower HbA1c (glycated hemoglobin), contributing to long-term diabetes control and reduction of diabetes-related complications when used as prescribed.
• May be used in patients who require combination therapy with dapagliflozin and metformin in a single tablet for improved treatment adherence, as directed by a physician.

Active Ingredients / Key Components:

• Dapagliflozin – 5 mg per film-coated tablet (sodium-glucose co-transporter 2 (SGLT2) inhibitor).
• Metformin hydrochloride – 1000 mg per film-coated tablet (biguanide class oral antidiabetic).
• Other inactive ingredients (excipients, film-coating agents, stabilizers, etc.) are present but specific details , please check the product leaflet or the manufacturer’s official website.

Dosage & Administration / How to Use:

• Use exactly as prescribed by your physician. Do not change your dose or stop the medicine without medical advice.
• Typical adult dose: One tablet taken once or twice daily, depending on individual prescription and previous metformin dose. The exact regimen must be determined by the treating doctor.
• Take the tablets with meals to reduce the risk of gastrointestinal side effects associated with metformin (such as nausea or stomach upset).
• Swallow the tablet whole with a glass of water. Do not crush, break, or chew the tablet unless your doctor or pharmacist specifically advises otherwise.
• If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not take a double dose to make up for a missed dose.
• Regular monitoring of blood glucose and HbA1c is recommended to assess treatment response and adjust dosage.
• Use in combination with other antidiabetic medications (such as insulin or sulfonylureas) only under close medical supervision due to increased risk of hypoglycemia.
• Not recommended for use in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis.

Clinical Benefits:

• Improved glycemic control: Combination of dapagliflozin and metformin helps reduce fasting and post-meal blood glucose and lowers HbA1c when diet, exercise, and metformin alone are not sufficient.
• Dual mechanism of action: Dapagliflozin inhibits SGLT2 in the kidneys, promoting urinary glucose excretion, while metformin decreases hepatic glucose production and improves insulin sensitivity.
• Weight and blood pressure support: The glycosuric effect of dapagliflozin may contribute to modest weight reduction and slight blood pressure lowering in some patients, as observed in clinical use.
• Convenient fixed-dose combination: Provides two effective antidiabetic agents in a single tablet, which may improve adherence and simplify treatment regimens.

Warnings & Contraindications:

• Contraindicated in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.
• Contraindicated in patients with severe renal impairment, end-stage renal disease, or on dialysis due to increased risk of adverse effects and reduced efficacy (metformin accumulation and reduced dapagliflozin action).
• Contraindicated in patients with acute or chronic metabolic acidosis, including diabetic ketoacidosis and lactic acidosis.
• Use with caution in patients with moderate renal impairment, liver disease, dehydration, low blood pressure, or in the elderly. Dose adjustment and close monitoring may be required.
• Metformin is associated with a rare but serious risk of lactic acidosis, especially in patients with renal dysfunction, dehydration, severe infection, heart failure, or in those consuming excessive alcohol.
• Dapagliflozin increases urinary glucose excretion and may increase the risk of genital mycotic infections and urinary tract infections. Maintain good personal hygiene and report symptoms early.
• May cause volume depletion (e.g., dizziness, low blood pressure), particularly in patients on diuretics, the elderly, or those with low blood pressure. Ensure adequate fluid intake unless otherwise advised.
• Consult your doctor before use if pregnant, planning pregnancy, or breastfeeding. Use during pregnancy or lactation should only occur if clearly needed and under strict medical supervision.
• Consult your doctor before use if you have kidney disease, liver disease, heart failure, recurrent urinary or genital infections, hypotension, or are taking diuretics or other antidiabetic medicines.
• Avoid excessive alcohol intake while on metformin due to increased risk of lactic acidosis.
• Not intended to diagnose, treat, cure, or prevent any disease without medical supervision; it is a prescription medicine for the management of type 2 diabetes as directed by a healthcare professional.
• Keep out of reach of children.

Side Effects:

• Common side effects: Genital fungal infections (e.g., vulvovaginal candidiasis, balanitis), urinary tract infections, increased urination, nausea, vomiting, diarrhea, abdominal discomfort, loss of appetite, headache, and dizziness.
• Metformin-related effects: Gastrointestinal disturbances such as nausea, diarrhea, abdominal pain, and metallic taste, especially at the start of therapy; usually improve with continued use and taking with food.
• Serious but rare side effects: Lactic acidosis (symptoms may include rapid breathing, muscle pain, unusual tiredness, abdominal pain, feeling cold, dizziness, or slow/irregular heartbeat); severe dehydration; severe urinary tract infection; ketoacidosis; or severe allergic reactions (rash, swelling, difficulty breathing).
• Hypoglycemia: Usually low when used alone with metformin, but risk increases if combined with insulin or sulfonylureas. Symptoms include sweating, tremor, hunger, confusion, palpitations, and weakness.
• Stop the medicine and seek immediate medical attention if you experience signs of lactic acidosis, severe infection, severe abdominal pain, difficulty breathing, or any signs of a serious allergic reaction.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Form: Film-coated tablet for oral use.
• Strength per tablet: dapagliflozin 5 mg + metformin hydrochloride 1000 mg.
• Pack size: 30 tablets per pack.
• Intended use: Prescription oral antidiabetic medicine for adults with type 2 diabetes mellitus.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.