Donifoxate 40 Mg 30 Tablets

Donifoxate 40 Mg 30 Tablets

Description:

Donifoxate 40 mg 30 tablets is a prescription oral medicine containing febuxostat, a xanthine oxidase inhibitor used to lower high uric acid levels in the blood. It is indicated for the long-term management of chronic hyperuricaemia in conditions where urate deposition has already occurred, such as a history of gouty arthritis or tophus formation. By reducing serum uric acid, Donifoxate helps prevent recurrent gout attacks and long-term joint damage associated with persistent hyperuricaemia.

Indications:

• Treatment of chronic hyperuricaemia in adult patients where urate deposition has already occurred (e.g. history of gout attacks or presence of tophi).
• Prevention of recurrent gout flares associated with elevated serum uric acid levels.
• Reduction of uric acid levels in patients who are intolerant to, or inadequately controlled with, other urate-lowering therapies such as allopurinol (as decided by the physician).

Active Ingredients / Key Components:

• Febuxostat – 40 mg per film-coated tablet.
• Other excipients (tablet core and film-coating agents) are present but detailed composition is not available in the provided information.

Dosage & Administration / How to Use:

• Recommended adult dose: 1 tablet (40 mg) once daily, or as directed by your physician.
• Tablets are taken orally, with or without food, at approximately the same time each day.
• Swallow the tablet whole with a sufficient amount of water; do not crush or chew.
• Your doctor may adjust the dose based on your serum uric acid levels and clinical response. Do not change the dose or stop treatment without medical advice.
• Donifoxate is intended for long-term treatment. Continue taking it even if you do not have symptoms, as stopping suddenly may increase uric acid levels and trigger gout attacks.
• If you miss a dose, take it as soon as you remember on the same day. If it is almost time for the next dose, skip the missed dose and resume your regular schedule. Do not take a double dose.
• Use only under medical supervision in patients with kidney or liver impairment; dose adjustment or additional monitoring may be required.

Clinical Benefits:

• Effectively lowers serum uric acid levels by inhibiting xanthine oxidase, the key enzyme responsible for uric acid production.
• Helps prevent recurrent painful gout attacks and reduces the risk of long-term joint damage associated with chronic hyperuricaemia.
• Supports gradual dissolution of urate crystals and tophi over time when target uric acid levels are maintained.
• Once-daily dosing improves treatment adherence and long-term management of gout and hyperuricaemia.

Warnings & Contraindications:

• Contraindicated in patients with known hypersensitivity to febuxostat or any of the excipients.
• Use with caution in patients with a history of major cardiovascular disease (e.g. myocardial infarction, stroke, unstable angina); discuss risks and benefits with your doctor.
• Use with caution in patients with severe renal or hepatic impairment; dose adjustment and close monitoring may be required.
• Acute gout attacks may still occur at the start of therapy due to mobilization of urate deposits. Do not stop the medicine during an attack unless instructed by your doctor; prophylactic treatment (e.g. low-dose NSAIDs or colchicine) may be recommended at initiation.
• Monitor liver function tests periodically during treatment as febuxostat may affect liver enzymes.
• Inform your doctor about all medications you are taking, especially azathioprine, mercaptopurine, theophylline, or other urate-lowering therapies, due to potential interactions.
• Consult your doctor before use if pregnant, planning pregnancy, or breastfeeding. Use only if the potential benefit justifies the potential risk.
• Not recommended for use in children and adolescents, as safety and efficacy in this age group have not been established.
• Patients with organ transplant receiving immunosuppressive therapy should only use febuxostat under strict specialist supervision.
• Consult your doctor before use if you have heart disease, kidney disease, liver disease, thyroid disorders, or a history of severe allergic reactions.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical supervision.
• Keep out of reach of children.

Side Effects:

• Common side effects may include headache, dizziness, nausea, diarrhea, abdominal pain, joint pain, or mild skin rash.
• Increased gout flares can occur during the initial phase of treatment as urate deposits are mobilized.
• Less common but serious side effects may include severe skin reactions, signs of liver problems (yellowing of skin or eyes, dark urine, persistent nausea), chest pain, shortness of breath, or sudden neurological symptoms.
• Stop taking the medicine and seek immediate medical attention if you experience severe rash, swelling of the face or throat, difficulty breathing, chest pain, or any symptoms of a serious allergic reaction.
• Report any persistent or bothersome side effects to your doctor or pharmacist for further evaluation.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children. Do not use after the expiry date printed on the pack. Store at or below the temperature indicated on the package insert (specific temperature information is not available in the provided data; follow pack instructions).

Specifications:

• Product form: Film-coated tablets.
• Strength: 40 mg febuxostat per tablet.
• Pack size: 30 film-coated tablets per pack.
• Intended use: Prescription urate-lowering medicine for adults with chronic hyperuricaemia associated with gout.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.