Donifoxate 80 Mg 30 Tablets

Donifoxate 80 Mg 30 Tablets

Description:

Donifoxate 80 mg 30 tablets is a prescription oral medicine containing febuxostat, a xanthine oxidase inhibitor used to lower high uric acid levels in the blood. Manufactured by EVA Pharma, it is indicated for the long-term management of chronic hyperuricaemia in conditions where urate deposition has already occurred, such as a history of gouty arthritis or tophus formation. By selectively inhibiting xanthine oxidase, Donifoxate helps reduce serum uric acid, preventing further crystal deposition and supporting gout control and hyperuricaemia management.

Indications:

• Treatment of chronic hyperuricaemia in adult patients where urate deposition has already occurred (e.g., history of gouty arthritis or tophus).
• Prevention of recurrent gout attacks associated with elevated serum uric acid levels.
• Reduction of uric acid levels in patients at risk of urate crystal deposition and gout-related joint pain, swelling, and inflammation.
• Long-term management of high uric acid levels to help prevent complications such as tophi and joint damage related to chronic gout.

Active Ingredients / Key Components:

• Febuxostat – 80 mg per film-coated tablet.
• Excipients: The full list of inactive ingredients (tablet core and coating) is not available in the provided information. Refer to the official package leaflet for complete excipient details.

Dosage & Administration / How to Use:

• Recommended adult dose: 1 tablet (80 mg) once daily, or as directed by your physician.
• Administration: Swallow the tablet whole with a glass of water. Do not crush or chew.
• With or without food: Donifoxate 80 mg can be taken with or without food.
• Duration of use: This medicine is intended for long-term treatment of chronic hyperuricaemia. Do not stop taking it without consulting your doctor, even if symptoms improve.
• Missed dose: If you miss a dose, take it as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.
• Special populations: Dose adjustments and careful monitoring may be required in patients with renal or hepatic impairment. Use only under medical supervision.
• Not for acute gout attacks: Donifoxate is not intended for the treatment of acute gout flares. Your doctor may prescribe additional medicines to manage acute attacks during the initiation of therapy.

Clinical Benefits:

• Effectively lowers serum uric acid levels by selectively inhibiting xanthine oxidase, the key enzyme in uric acid production.
• Helps prevent recurrent gout attacks and reduces the risk of painful joint inflammation and swelling associated with hyperuricaemia.
• Supports long-term control of chronic gout by decreasing urate crystal formation and promoting gradual dissolution of existing deposits.
• Contributes to protecting joints and soft tissues from damage related to long-standing urate deposition and tophi formation.

Warnings & Contraindications:

• Contraindicated in patients with known hypersensitivity to febuxostat or any of the excipients.
• Not recommended in patients being treated with azathioprine, mercaptopurine, or theophylline unless under strict specialist supervision, due to potential serious interactions.
• Use with caution in patients with a history of major cardiovascular disease (e.g., heart attack, stroke, unstable angina); discuss risks and benefits with your doctor.
• Patients with severe renal or hepatic impairment require careful evaluation and monitoring before and during treatment.
• Acute gout attacks may occur when starting urate-lowering therapy; your doctor may prescribe prophylactic treatment (e.g., NSAIDs or colchicine) during initiation.
• Consult your doctor before use if pregnant, planning pregnancy, or breastfeeding. Use only if clearly needed and prescribed.
• Consult your doctor before use if you have liver disease, kidney disease, heart disease, thyroid disorders, or are taking other regular medications.
• Do not use this medicine to treat acute pain or for conditions other than those prescribed by your physician.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical supervision.
• Keep out of reach of children.

Side Effects:

• Common side effects may include headache, nausea, diarrhea, abdominal pain, joint pain, and mild rash.
• Less common side effects can include liver function test abnormalities, dizziness, and edema. Your doctor may periodically monitor liver function.
• Serious but rare side effects may include severe allergic reactions (such as widespread rash, itching, swelling of the face or throat, difficulty breathing), severe skin reactions, or cardiovascular events. Seek immediate medical attention if these occur.
• If you experience persistent or worsening side effects, or any unusual symptoms, contact your healthcare provider promptly.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Form: Film-coated tablets.
• Strength: 80 mg febuxostat per tablet.
• Pack size: 30 tablets per pack.
• Intended use: Oral prescription medicine for adults for long-term management of chronic hyperuricaemia and gout-related conditions.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.