Prontogest 400 Mg 30 Suppository

Prontogest 400 Mg 30 Suppository

Description:

Prontogest 400 mg vaginal/rectal pessaries are a prescription hormonal medicine containing natural micronized progesterone. They are used to supplement or replace progesterone in women with documented deficiency, particularly during assisted reproductive technology (ART) treatments, and in several gynecological and menopausal conditions. Each suppository is designed for vaginal or rectal administration to provide systemic progesterone support, helping to regulate the menstrual cycle, stabilize the endometrium, and support early pregnancy when indicated by a specialist. This product is intended for adult women under medical supervision.

Indications:

• Progesterone supplementation or replacement as part of assisted reproductive technology (ART) treatment in infertile women with progesterone deficiency (e.g., IVF cycles), as prescribed by a fertility specialist.
• Treatment of secondary amenorrhea (absence of menstrual periods in women who previously had normal cycles) due to progesterone deficiency.
• Reduction of the incidence of endometrial hyperplasia in postmenopausal women receiving estrogen replacement therapy, thereby lowering the associated risk of endometrial carcinoma.
• Treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology such as fibroids or uterine cancer.
• Support of the luteal phase when progesterone deficiency is diagnosed, as directed by a gynecologist.

Active Ingredients / Key Components:

• Progesterone (micronized) – 400 mg per vaginal/rectal pessary
• Excipients: The full list of inactive ingredients (base and stabilizers) is not available in the provided information. Please refer to the official package leaflet for complete excipient details.

Dosage & Administration / How to Use:

• Use only as prescribed by your doctor or fertility specialist. Dosage and duration vary according to indication (ART support, secondary amenorrhea, hormone replacement therapy, or abnormal uterine bleeding).
• Route of administration: Vaginal or rectal use only. Do not swallow.
• Common regimens (for reference only – your doctor may adjust):
  • ART / luteal phase support: Often 400 mg once or twice daily via vaginal route, starting after ovulation or embryo transfer and continuing as directed by the specialist.
  • Secondary amenorrhea / abnormal uterine bleeding: Typically given for a defined number of days in the second half of the cycle to induce withdrawal bleeding, as per physician instructions.
  • With estrogen replacement therapy: Administered for part of each cycle (e.g., 10–14 days per month) to protect the endometrium, as prescribed.
• Vaginal use: Wash and dry hands, remove the pessary from its packaging, lie on your back with knees bent, and gently insert the suppository deep into the vagina, preferably at bedtime to reduce leakage.
• Rectal use: Wash and dry hands, if possible empty the bowel first, gently insert the pessary into the rectum while lying on your side, and remain lying for a few minutes.
• Use at the same time(s) each day for best effect.
• If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose.
• Do not stop treatment abruptly without consulting your doctor, especially during early pregnancy or ART cycles.

Clinical Benefits:

• Provides reliable progesterone supplementation in women with luteal phase or general progesterone deficiency.
• Supports implantation and early pregnancy maintenance in ART cycles when prescribed by a fertility specialist.
• Helps regulate the menstrual cycle and induce withdrawal bleeding in cases of secondary amenorrhea due to hormonal imbalance.
• Reduces the risk of estrogen-induced endometrial hyperplasia and subsequent risk of endometrial carcinoma in postmenopausal women on estrogen therapy.
• Stabilizes the endometrium and helps control abnormal uterine bleeding related to hormonal imbalance in the absence of structural uterine disease.

Warnings & Contraindications:

• Use only under the supervision of a qualified healthcare professional. This is a prescription hormonal medicine.
• Contraindicated in known or suspected pregnancy unless specifically prescribed for luteal support or ART by your doctor.
• Contraindicated in known or suspected breast or genital tract malignancy (e.g., breast cancer, endometrial cancer), unless your specialist decides otherwise.
• Do not use in cases of undiagnosed vaginal bleeding, active or recent thromboembolic disorders (e.g., deep vein thrombosis, pulmonary embolism), severe liver disease, or known hypersensitivity to progesterone or any excipient.
• Use with caution in patients with a history of depression, migraine, epilepsy, asthma, diabetes, or cardiovascular disease; close medical monitoring may be required.
• May cause drowsiness or dizziness in some patients; avoid driving or operating machinery if affected.
• Consult your doctor before use if pregnant, planning pregnancy, or breastfeeding. Progesterone use in pregnancy must be individualized and supervised by a specialist.
• Inform your doctor about all other medicines you are taking, including hormonal therapies, anticoagulants, and herbal supplements, to avoid interactions.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical evaluation and prescription.
• Keep out of reach of children.

Side Effects:

• Common side effects may include headache, breast tenderness, abdominal discomfort, bloating, nausea, drowsiness, dizziness, mood changes, or local irritation/discharge at the site of insertion.
• Less common effects can include changes in menstrual bleeding pattern, spotting, fluid retention, or weight changes.
• Serious side effects (seek immediate medical attention) may include signs of thromboembolism (sudden leg pain or swelling, chest pain, shortness of breath), severe headache, visual disturbances, jaundice (yellowing of skin or eyes), or severe depression.
• Allergic reactions such as rash, itching, swelling of the face or tongue, or difficulty breathing require urgent medical care.
• If you experience any unexpected or persistent side effects, contact your doctor or pharmacist promptly.

Storage Instructions:

Store in a cool, dry place away from direct sunlight and heat sources. Keep the blister pack tightly closed until use. Do not store above the temperature stated on the package (specific temperature information is not available here; please refer to the product carton). Keep out of reach of children. Do not use after the expiry date printed on the pack.

Specifications:

• Form: Vaginal/rectal pessaries (suppositories)
• Strength: 400 mg progesterone per pessary
• Pack size: 30 pessaries per pack
• Intended user group: Adult women, under medical supervision

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.