Nevilob Plus 5/12.5 Mg 20 Tablets

Nevilob Plus 5/12.5 Mg 20 Tablets

Description:

Nevilob Plus 5/12.5 mg 20 tablets is a prescription antihypertensive medicine that combines a beta-1 selective blocker (nebivolol) with a thiazide diuretic (hydrochlorothiazide) to effectively lower high blood pressure and help protect cardiovascular health. This fixed-dose combination is produced by Marcyrl Pharmaceutical Industries (MPI) and is designed for adult patients who require dual therapy to achieve optimal blood pressure control. By reducing vascular resistance and promoting gentle diuresis, Nevilob Plus supports long-term management of hypertension and helps reduce the risk of complications such as stroke, heart attack, and heart failure when used as part of a comprehensive treatment plan.

Indications:

• Treatment of essential (primary) hypertension in adults.
• Management of high blood pressure in patients who require combination therapy with a beta-blocker and a thiazide diuretic.
• Helps reduce cardiovascular risk associated with uncontrolled hypertension, such as stroke, myocardial infarction, and other heart and vascular complications (as part of overall medical management and lifestyle modification).

Active Ingredients / Key Components:

• Nebivolol hydrochloride – 5 mg per tablet (third-generation cardioselective beta-1 receptor antagonist).
• Hydrochlorothiazide – 12.5 mg per tablet (thiazide diuretic).
• Excipients: Information on inactive ingredients (excipients, coloring agents, preservatives, etc.) is not available in the provided data. Please refer to the official package leaflet for the full excipient list.

Dosage & Administration / How to Use:

• Nevilob Plus 5/12.5 mg is for oral use only and should be taken exactly as prescribed by a physician.
• Typical adult dose: 1 tablet once daily, preferably at the same time each day. The tablet may be taken with or without food, with a glass of water.
• Swallow the tablet whole; do not crush, chew, or break unless your doctor or pharmacist specifically advises otherwise.
• Use in elderly patients (>65 years): Dose adjustment may be required. Treatment is usually started with lower doses of nebivolol alone (e.g., 2.5 mg) before switching to or adding a combination product like Nevilob Plus, according to the doctor’s judgment.
• Use in renal impairment: Patients with reduced kidney function often start on lower doses of nebivolol monotherapy (e.g., 2.5 mg) and are carefully monitored. The decision to use a fixed-dose combination with hydrochlorothiazide must be made by the treating physician.
• Do not change the dose or stop taking the medication suddenly without medical advice, as abrupt discontinuation of beta-blockers may worsen heart or blood pressure control.
• If you miss a dose, take it as soon as you remember on the same day. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed tablet.

Clinical Benefits:

• Provides dual antihypertensive action by combining nebivolol (beta-1 blocker with vasodilatory properties) and hydrochlorothiazide (thiazide diuretic) for more effective blood pressure reduction.
• Nebivolol helps reduce vascular resistance and acutely lowers arterial blood pressure without significantly depressing left ventricular function, supporting stable cardiac performance.
• Promotes coronary vasodilation and improves myocardial ischemia through nitric oxide–mediated vasodilation, contributing to better oxygen supply to the heart muscle.
• Hydrochlorothiazide enhances urinary excretion of sodium and water, reducing blood volume and helping to maintain controlled blood pressure over time.
• Once-daily dosing supports convenient and consistent blood pressure management, which may improve treatment adherence.

Warnings & Contraindications:

• Use only under medical supervision. This is a prescription-only antihypertensive medicine.
• Contraindicated in patients with known hypersensitivity to nebivolol, hydrochlorothiazide, other sulfonamide-derived drugs, or any component of the formulation.
• Contraindicated in severe bradycardia, second- or third-degree atrioventricular (AV) block, sick sinus syndrome (unless a functioning pacemaker is present), cardiogenic shock, uncontrolled heart failure, or severe peripheral circulatory disorders.
• Contraindicated in severe hepatic impairment or severe renal impairment/anuria (for the hydrochlorothiazide component), unless specifically evaluated and approved by a specialist.
• Use with caution in patients with diabetes, as beta-blockers may mask signs of hypoglycemia, and thiazides may affect blood glucose levels.
• Use with caution in patients with gout or hyperuricemia, as hydrochlorothiazide may increase uric acid levels.
• Use with caution in patients with electrolyte disturbances (such as low potassium, sodium, or magnesium) or those taking other medicines that affect electrolytes.
• Patients with asthma or chronic obstructive pulmonary disease (COPD) should use beta-blockers cautiously, even if cardioselective, and only under close medical supervision.
• Consult your doctor before use if pregnant or planning pregnancy. Beta-blockers and thiazide diuretics are generally not recommended during pregnancy unless clearly needed. Your doctor will decide the safest option.
• Breastfeeding: Nebivolol and hydrochlorothiazide may pass into breast milk; use during lactation only if the potential benefit justifies the potential risk and under medical advice.
• Inform your doctor about all other medications you are taking, including other antihypertensives, antiarrhythmics, antidepressants, NSAIDs, lithium, or any over-the-counter or herbal products, to avoid interactions.
• May cause dizziness or fatigue in some patients; avoid driving or operating machinery until you know how the medicine affects you.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical supervision; it is specifically for the treatment of diagnosed hypertension as prescribed.
• Keep out of reach of children.

Side Effects:

• Common side effects may include headache, dizziness, fatigue, weakness, slow heart rate (bradycardia), and gastrointestinal disturbances such as nausea or abdominal discomfort.
• Hydrochlorothiazide-related effects may include increased urination, electrolyte imbalances (low potassium, sodium, or magnesium), increased uric acid, or mild increases in blood glucose or cholesterol levels.
• Some patients may experience cold extremities, flushing, or mild swelling, as well as sleep disturbances or mood changes.
• Serious side effects (seek immediate medical attention) may include severe dizziness or fainting, very slow or irregular heartbeat, severe shortness of breath, sudden swelling of face, lips, or tongue (angioedema), severe skin reactions, or signs of significant electrolyte imbalance (muscle cramps, confusion, irregular heartbeat).
• If you notice any unusual or persistent symptoms, contact your doctor or pharmacist promptly.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Product type: Prescription antihypertensive medicine (beta-blocker + thiazide diuretic combination).
• Strength: 5 mg nebivolol hydrochloride + 12.5 mg hydrochlorothiazide per tablet.
• Form: Film-coated tablets for oral use.
• Pack size: 20 tablets per pack.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.