Nevilob Plus 5/25 Mg 20 Tablets

Nevilob Plus 5/25 Mg 20 Tablets

Description:

Nevilob Plus 5/25 mg 20 tablets is a prescription antihypertensive medicine combining a beta-1 selective blocker (nebivolol) with a thiazide diuretic (hydrochlorothiazide). It is used for the treatment and long-term control of high blood pressure (hypertension) in adults, especially when monotherapy is insufficient. By reducing vascular resistance and promoting gentle diuresis, Nevilob Plus helps lower arterial blood pressure, supports cardiovascular protection, and reduces the risk of complications such as stroke and heart attack when used as part of a comprehensive hypertension management plan.

Indications:

• Treatment of essential hypertension (high blood pressure) in adults.
• Management of patients whose blood pressure is not adequately controlled with nebivolol or hydrochlorothiazide alone.
• Reduction of cardiovascular risk associated with sustained high blood pressure, such as risk of stroke, myocardial infarction, and other hypertension-related complications (as part of overall medical management and lifestyle modification).

Active Ingredients / Key Components:

• Nebivolol hydrochloride – 5 mg per tablet (third-generation cardioselective beta-1 receptor antagonist; exact salt-equivalent details beyond 5 mg are not provided on the pack).
• Hydrochlorothiazide – 25 mg per tablet (thiazide diuretic; promotes excretion of sodium and water to help lower blood pressure).
• Other inactive ingredients (excipients) are present in the tablet formulation, but detailed excipient composition is not available in the provided information.

Dosage & Administration / How to Use:

• Nevilob Plus is for oral use only and should be taken exactly as prescribed by your physician.
• Usual adult dose: 1 tablet once daily, preferably at the same time each day. The exact dose and duration are determined by the treating doctor based on blood pressure response and individual patient factors.
• Tablets may be taken with or without food; take with a glass of water and do not crush or chew unless advised otherwise by your doctor.
• In elderly patients (above 65 years) or those with renal impairment, therapy with nebivolol alone is typically initiated at 2.5 mg and titrated; the fixed-dose combination Nevilob Plus should only be used after a physician decides that the combined strength (5/25 mg) is appropriate.
• Do not change your dose, skip doses, or stop taking Nevilob Plus without consulting your doctor, as sudden discontinuation may worsen cardiovascular status.
• If you miss a dose, take it as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose to make up for a missed tablet.

Clinical Benefits:

• Provides effective blood pressure reduction through dual action: beta-1 receptor blockade (nebivolol) and mild diuresis (hydrochlorothiazide).
• Reduces peripheral vascular resistance and acutely lowers arterial blood pressure without significantly depressing left ventricular function.
• Promotes coronary vasodilatation and may improve myocardial ischaemia via nitric oxide–mediated vasodilation (nebivolol effect).
• Supports long-term cardiovascular protection when used regularly as part of a comprehensive hypertension management plan (including diet, exercise, and lifestyle changes).

Warnings & Contraindications:

• Use only under medical supervision. Nevilob Plus is a prescription medicine for adults and should not be used without a doctor’s recommendation.
• Contraindicated in patients with known hypersensitivity to nebivolol, hydrochlorothiazide, other sulfonamide-derived drugs, or any component of the formulation.
• Contraindicated in severe bradycardia, second- or third-degree heart block, sick sinus syndrome (unless a functioning pacemaker is present), cardiogenic shock, decompensated heart failure, and severe peripheral circulatory disorders.
• Contraindicated in severe renal impairment, anuria, or severe hepatic impairment, and in patients with refractory hypokalemia, hypercalcemia, or symptomatic hyperuricemia/gout related to thiazide use.
• Use with caution in patients with diabetes mellitus (may mask symptoms of hypoglycemia), thyroid disorders, bronchospastic disease (e.g., asthma, COPD), peripheral vascular disease, or a history of psoriasis.
• Hydrochlorothiazide may affect electrolyte balance (sodium, potassium, magnesium) and renal function; periodic monitoring of serum electrolytes, renal function, and uric acid is recommended.
• Consult your doctor before use if pregnant or planning pregnancy. Beta-blockers and thiazide diuretics are generally not recommended during pregnancy unless clearly needed. Inform your doctor if you are breastfeeding, as components may pass into breast milk.
• Inform your doctor about all other medicines you are taking, including other antihypertensives, antiarrhythmics, antidepressants, NSAIDs, lithium, antidiabetic drugs, and any over-the-counter or herbal products, due to potential interactions.
• May cause dizziness or fatigue; use caution when driving or operating machinery until you know how the medicine affects you.
• Not intended to diagnose, treat, cure, or prevent any disease outside its approved indications.
• Keep out of reach of children.

Side Effects:

• Common side effects may include headache, dizziness, fatigue, slow heart rate (bradycardia), cold extremities, nausea, abdominal discomfort, and mild gastrointestinal disturbances.
• Due to hydrochlorothiazide, possible side effects include increased urination, electrolyte disturbances (low potassium, low sodium), increased uric acid (which may precipitate gout), mild increases in blood glucose, and photosensitivity reactions.
• Less common but serious side effects can include severe bradycardia, worsening heart failure, significant hypotension, severe electrolyte imbalance, allergic reactions, or visual disturbances.
• Seek immediate medical attention if you experience severe dizziness or fainting, difficulty breathing, swelling of the face or tongue, chest pain, irregular heartbeat, or signs of severe dehydration or electrolyte imbalance (such as muscle weakness, confusion, or palpitations).

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Form: Tablet.
• Strength: 5 mg nebivolol hydrochloride + 25 mg hydrochlorothiazide per tablet.
• Pack size: 20 tablets per pack.
• Route of administration: Oral.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.