Augmentin 457 Mg Syrup 5 ml

Augmentin 457 Mg Syrup 5 ml

Description:

Augmentin 457 mg/5 ml syrup is a prescription systemic antibiotic medicine containing amoxicillin and clavulanic acid, used to treat a wide range of bacterial infections in adults and children. It belongs to the penicillin class and is formulated as an oral suspension for convenient dosing, especially in pediatric patients. By combining amoxicillin with the beta-lactamase inhibitor clavulanic acid, Augmentin effectively targets beta-lactamase–producing bacteria that are resistant to amoxicillin alone, providing broad-spectrum coverage for respiratory, ear, sinus, skin, and urinary tract infections.

Indications:

• Lower respiratory tract infections, including bronchitis and pneumonia, caused by beta-lactamase–producing isolates of Haemophilus influenzae and Moraxella catarrhalis.
• Acute bacterial otitis media (middle ear infection) caused by beta-lactamase–producing H. influenzae and M. catarrhalis.
• Acute bacterial sinusitis caused by beta-lactamase–producing H. influenzae and M. catarrhalis.
• Skin and skin structure infections caused by beta-lactamase–producing Staphylococcus aureus, Escherichia coli, and Klebsiella species.
• Urinary tract infections (UTIs) caused by beta-lactamase–producing E. coli, Klebsiella species, and Enterobacter species.
• Other susceptible infections as determined by culture and sensitivity testing, according to physician judgment.

Active Ingredients / Key Components:

• Amoxicillin (as amoxicillin trihydrate) – 400 mg per 5 ml oral suspension (equivalent strength within the 457 mg/5 ml combination).
• Clavulanic acid (as potassium clavulanate) – 57 mg per 5 ml oral suspension.
• Total combined strength – 457 mg per 5 ml (amoxicillin + clavulanic acid).
• Excipients (inactive ingredients) – may include sweeteners, suspending agents, flavoring agents, and preservatives (exact excipient list and concentrations , please check the product leaflet or the manufacturer’s official website; please refer to the package insert).

Dosage & Administration / How to Use:

• Use only as prescribed by a physician. Dosage depends on the type and severity of infection, patient age, and body weight.
• Typical pediatric dosing is based on amoxicillin component (mg/kg/day) divided into 2 doses per day; the 457 mg/5 ml strength is often used for higher-dose regimens in more severe infections. Exact dose must be determined by the doctor.
• Shake the bottle well before each use to ensure uniform suspension.
• Measure the dose accurately using a medical measuring spoon, oral syringe, or dosing cup. Do not use household teaspoons.
• It is generally recommended to take Augmentin at the start of a meal to improve absorption and reduce gastrointestinal side effects.
• Administer at evenly spaced intervals (usually every 12 hours for this strength), or as directed by the physician.
• Continue treatment for the full prescribed course, even if symptoms improve earlier, to prevent relapse and antibiotic resistance.
• If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to make up for a missed one.
• For reconstituted suspension: follow pharmacist or package instructions for adding water to the dry powder and shaking until a uniform suspension is obtained.

Clinical Benefits:

• Provides broad-spectrum antibacterial activity by combining amoxicillin with clavulanic acid to overcome beta-lactamase–mediated resistance.
• Effectively treats common respiratory tract infections such as otitis media, sinusitis, and bronchitis caused by resistant organisms.
• Helps resolve signs and symptoms of skin, soft tissue, and urinary tract infections, including pain, fever, and inflammation.
• Oral syrup form facilitates accurate dosing and easier administration, especially in children and patients who have difficulty swallowing tablets.

Warnings & Contraindications:

• Contraindicated in patients with a known history of hypersensitivity (allergy) to amoxicillin, clavulanic acid, other penicillins, or any component of the formulation.
• Cross-sensitivity may occur in patients allergic to other beta-lactam antibiotics (e.g., cephalosporins); use with caution and under medical supervision.
• Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported with penicillins; discontinue immediately and seek emergency care if signs of allergy (rash, itching, swelling, difficulty breathing) occur.
• Use with caution in patients with hepatic impairment or history of liver dysfunction associated with amoxicillin/clavulanate; monitor liver function tests if needed.
• Use with caution in patients with renal impairment; dosage adjustment may be required.
• Prolonged use may result in overgrowth of non-susceptible organisms, including fungi; if superinfection occurs, appropriate therapy should be instituted.
• Antibiotic-associated colitis, including Clostridioides difficile–associated diarrhea, has been reported; consider this diagnosis in patients with severe or persistent diarrhea.
• Consult your doctor before use if pregnant or nursing. Use during pregnancy and lactation only if clearly needed and prescribed by a physician.
• Inform your doctor about all medications you are taking, especially anticoagulants (e.g., warfarin), allopurinol, or other antibiotics, due to potential interactions.
• Not intended to diagnose, treat, cure, or prevent any disease without medical supervision; it is a prescription medicine that must be used under a doctor’s guidance.
• Keep out of reach of children.

Side Effects:

• Common side effects: nausea, vomiting, diarrhea, abdominal discomfort, and mild skin rash.
• Less common side effects: headache, dizziness, oral or vaginal candidiasis (thrush), and changes in taste.
• Serious side effects (seek immediate medical attention): severe allergic reactions (anaphylaxis), widespread rash, blistering or peeling skin, jaundice (yellowing of skin or eyes), dark urine, severe or persistent diarrhea, or unusual bleeding/bruising.
• If any side effect is severe, persistent, or concerning, stop the medication and contact your doctor or pharmacist promptly.

Storage Instructions:

Store the dry powder (before reconstitution) at room temperature in a cool, dry place away from direct sunlight. Keep the container tightly closed. After reconstitution with water, store the suspension in a refrigerator (usually 2–8 °c) and use within the period specified in the package insert (commonly 7–10 days). Do not freeze. Discard any unused suspension after the recommended period. Keep out of reach of children.

Specifications:

• Product type: Oral antibiotic medicine (systemic antibiotic).
• Form: Syrup / oral suspension.
• Strength: 457 mg/5 ml (amoxicillin 400 mg + clavulanic acid 57 mg per 5 ml).
• Pack size: 70 ml after reconstitution (based on available product information for Augmentin 457 mg/5 ml susp. 70 ml).
• Route of administration: Oral.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.