Augmentin Es-600 Syrup 75 ml

Augmentin Es-600 Syrup 75 ml

Description:

Augmentin Es-600 Syrup 75 ml is a prescription systemic antibiotic medicine containing amoxicillin and clavulanic acid, formulated as a powder for oral suspension to be reconstituted by the pharmacist. It belongs to the beta-lactam/penicillin class and is designed to treat a wide range of bacterial infections, particularly those caused by beta-lactamase–producing organisms that are resistant to amoxicillin alone. This high-strength ES (extended spectrum) formulation is commonly used in pediatric patients and adults who require an oral antibiotic in liquid form when tablets or capsules are not suitable.

Indications:

• Lower respiratory tract infections, including bronchitis and pneumonia, caused by beta-lactamase–producing isolates of Haemophilus influenzae and Moraxella catarrhalis.
• Acute bacterial otitis media (middle ear infection) caused by beta-lactamase–producing isolates of H. influenzae and M. catarrhalis.
• Acute bacterial sinusitis caused by beta-lactamase–producing isolates of H. influenzae and M. catarrhalis.
• Skin and skin structure infections caused by beta-lactamase–producing isolates of Staphylococcus aureus, Escherichia coli, and Klebsiella species.
• Urinary tract infections (UTIs) caused by beta-lactamase–producing isolates of E. coli, Klebsiella species, and Enterobacter species.
• Other infections due to susceptible organisms as determined by your physician and local antibiotic guidelines.

Active Ingredients / Key Components:

• Amoxicillin (as amoxicillin trihydrate) – 600 mg per 5 ml oral suspension (concentration based on standard Augmentin ES-600 formulations; exact concentration on local pack may vary and should be confirmed on the product label).
• Clavulanic acid (as potassium clavulanate) – 42.9 mg per 5 ml oral suspension (concentration based on standard Augmentin ES-600 formulations; exact concentration on local pack may vary and should be confirmed on the product label).
• Excipients: The full list of inactive ingredients (such as sweeteners, flavoring agents, suspending agents, and preservatives) is not available in the provided information. Please refer to the package leaflet for a complete ingredient list.

Dosage & Administration / How to Use:

• Augmentin Es-600 is for oral use only and must be taken exactly as prescribed by your doctor.
• The bottle contains powder for oral suspension and should be reconstituted by the pharmacist with the recommended amount of water to obtain 75 ml of suspension. Shake well after reconstitution and before each dose.
• Typical pediatric dosing is based on body weight (mg/kg/day of the amoxicillin component) divided into 2 doses per day. The exact dose, frequency, and duration are determined by the physician according to the type and severity of infection and the patient’s age and weight.
• For adults and adolescents who cannot swallow tablets, the doctor may also prescribe this suspension with an appropriate dose calculated by weight and clinical condition.
• It is generally recommended to take Augmentin Es-600 at the start of a meal to improve absorption and reduce the risk of gastrointestinal side effects.
• Use the provided measuring device (oral syringe or measuring spoon) to ensure accurate dosing. Do not use household teaspoons.
• Continue the full course of therapy even if symptoms improve earlier, unless your doctor advises otherwise. Stopping treatment too soon may lead to recurrence or antibiotic resistance.
• If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose to make up for a missed one.

Clinical Benefits:

• Provides broad-spectrum antibacterial activity by combining amoxicillin with clavulanic acid to overcome resistance from beta-lactamase–producing bacteria.
• Effectively treats respiratory tract infections such as otitis media, sinusitis, and lower respiratory infections, helping relieve symptoms like fever, cough, ear pain, and sinus pressure.
• Helps manage skin and soft tissue infections and urinary tract infections caused by susceptible organisms, promoting faster recovery and preventing complications.
• Oral suspension form is particularly suitable for children and patients who have difficulty swallowing tablets, improving adherence to treatment.

Warnings & Contraindications:

• Contraindicated in patients with a known hypersensitivity (allergy) to amoxicillin, clavulanic acid, other penicillins, or any of the excipients.
• Cross-sensitivity may occur in patients allergic to other beta-lactam antibiotics such as cephalosporins and carbapenems; use with caution and under medical supervision.
• History of cholestatic jaundice or hepatic dysfunction associated with amoxicillin/clavulanate use is a contraindication to further use of this combination.
• Use with caution in patients with liver impairment or kidney impairment; dose adjustment may be required and liver/kidney function should be monitored.
• Prolonged use may result in overgrowth of non-susceptible organisms, including fungi; if superinfection occurs, appropriate measures should be taken.
• Antibiotic-associated colitis (including Clostridioides difficile–associated diarrhea) has been reported; if severe or persistent diarrhea occurs, discontinue the medicine and seek medical advice immediately.
• Consult your doctor before use if pregnant or breastfeeding. Amoxicillin and clavulanic acid are excreted in breast milk; the doctor will weigh benefits versus potential risks.
• Inform your doctor about all other medications you are taking, especially anticoagulants (e.g., warfarin), allopurinol, methotrexate, or other antibiotics, as interactions may occur.
• May interfere with some laboratory tests (e.g., urine glucose tests using non-enzymatic methods); inform laboratory staff that you are taking Augmentin.
• Not intended to diagnose, treat, cure, or prevent any disease without a doctor’s prescription and supervision.
• Keep out of reach of children.

Side Effects:

• Common side effects: nausea, vomiting, diarrhea, abdominal discomfort, and mild skin rash. Taking the medicine at the start of a meal may reduce gastrointestinal symptoms.
• Less common side effects: headache, dizziness, candidiasis (oral or vaginal thrush), and changes in liver enzymes on blood tests.
• Serious side effects (seek immediate medical attention): severe allergic reactions such as anaphylaxis, angioedema (swelling of face, lips, tongue, or throat), severe skin reactions (Stevens–Johnson syndrome, toxic epidermal necrolysis), severe or persistent diarrhea, yellowing of the skin or eyes (jaundice), dark urine, or unusual bruising or bleeding.
• If any side effects become severe, persistent, or you notice any other unusual symptoms, stop the medication and contact your doctor or pharmacist promptly.

Storage Instructions:

Store the unopened dry powder in a cool, dry place away from direct sunlight, at or below the temperature indicated on the package. After reconstitution, store the suspension in a refrigerator (2–8 °c) and keep the bottle tightly closed. Do not freeze. Use within the period specified on the label after reconstitution (commonly 7–10 days; check local pack instructions), then discard any remaining suspension. Keep out of reach of children.

Specifications:

• Form: Powder for oral suspension to be reconstituted to 75 ml syrup.
• Strength: Amoxicillin 600 mg/5 ml + clavulanic acid 42.9 mg/5 ml (based on standard Augmentin Es-600 formulations; verify exact local concentration on pack).
• Route of administration: Oral.
• Pack size: 75 ml after reconstitution.
• Intended use: Prescription systemic antibiotic for the treatment of susceptible bacterial infections.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.