Cholerose Plus 10/10 Mg 28 Tablets

Cholerose Plus 10/10 Mg 28 Tablets

Description:

Cholerose Plus 10/10 mg is a prescription lipid-lowering medication combining two active ingredients, rosuvastatin and ezetimibe, in one film-coated tablet. It is used as part of a comprehensive cardiovascular risk reduction plan to help lower high cholesterol and triglycerides and improve overall lipid profile in adults and suitable adolescents, usually alongside a low-fat diet and lifestyle modifications. By targeting both hepatic cholesterol synthesis and intestinal cholesterol absorption, Cholerose Plus provides dual-action control of dyslipidemia to help reduce the risk of atherosclerotic cardiovascular disease as directed by a physician.

Indications:

• Treatment of primary hypercholesterolemia (high cholesterol), including heterozygous familial and non-familial hypercholesterolemia, when diet and lifestyle changes alone are insufficient.
• Adjunct to diet in patients with mixed dyslipidemia (elevated LDL cholesterol, total cholesterol, triglycerides, and/or low HDL cholesterol).
• Patients requiring additional LDL cholesterol reduction when already treated with a statin or ezetimibe alone but not adequately controlled.
• Prevention and management of atherosclerotic cardiovascular disease risk associated with elevated LDL cholesterol, as part of a comprehensive risk reduction strategy prescribed by a doctor.

Active Ingredients / Key Components:

• Ezetimibe – 10 mg per film-coated tablet (inhibits intestinal absorption of dietary and biliary cholesterol).
• Rosuvastatin – 10 mg per film-coated tablet (HMG-CoA reductase inhibitor/statin that reduces hepatic cholesterol synthesis and increases LDL receptor activity).
• Other excipients: Film-coating and tablet core excipients (fillers, binders, colorants, stabilizers) – detailed inactive ingredient list is not available in the provided data. Please refer to the official package leaflet for the full excipient list.

Dosage & Administration / How to Use:

• Use Cholerose Plus 10/10 mg exactly as prescribed by your physician. Do not change your dose or stop treatment without medical advice.
• Typical adult dose: 1 tablet (10 mg rosuvastatin / 10 mg ezetimibe) once daily. The exact dose and duration are determined by your doctor based on your cholesterol levels, cardiovascular risk, and response to therapy.
• Administration: Swallow the film-coated tablet whole with a glass of water. Do not crush or chew.
• Timing: Can be taken with or without food, preferably at the same time each day to maintain consistent blood levels.
• Diet and lifestyle: Continue a cholesterol-lowering diet, regular exercise, weight control, and smoking cessation as recommended by your healthcare provider.
• Concomitant medications: If you are taking bile acid sequestrants (e.g., cholestyramine), take Cholerose Plus at least 2 hours before or 4 hours after these medicines to avoid reduced absorption of ezetimibe.
• Missed dose: If you miss a dose, take it as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose. Do not take a double dose to make up for a forgotten tablet.
• Special populations: Dose adjustments or additional monitoring may be required in patients with kidney impairment, liver impairment, elderly patients, or those taking certain interacting medicines. Follow your doctor’s instructions carefully.

Clinical Benefits:

• Provides dual mechanism of action by inhibiting both cholesterol synthesis in the liver (rosuvastatin) and cholesterol absorption in the intestine (ezetimibe) for enhanced lipid control.
• Effectively lowers LDL ("bad") cholesterol and total cholesterol, helping to improve overall lipid profile when combined with diet and lifestyle modifications.
• Helps reduce elevated triglycerides and may modestly increase HDL ("good") cholesterol, contributing to better cardiovascular risk management.
• Convenient once-daily combination tablet may improve adherence compared with taking rosuvastatin and ezetimibe separately.

Warnings & Contraindications:

• Contraindicated in patients with active liver disease, unexplained persistent elevations of serum transaminases, or severe hepatic impairment.
• Contraindicated in patients with known hypersensitivity to rosuvastatin, ezetimibe, or any component of the formulation.
• Contraindicated during pregnancy and breastfeeding. Statins may cause harm to the fetus; women of childbearing potential should use effective contraception during treatment and discontinue immediately if pregnancy occurs.
• Use with caution in patients with a history of liver disease, heavy alcohol use, kidney impairment, hypothyroidism, or personal/family history of hereditary muscle disorders.
• Risk of myopathy and rhabdomyolysis: Report unexplained muscle pain, tenderness, weakness, or cramps, especially if accompanied by malaise or fever. Your doctor may check creatine kinase (CK) levels and adjust or stop treatment.
• Monitor liver function tests before starting therapy and periodically thereafter as recommended by your physician.
• Drug interactions: Use caution and inform your doctor if you are taking cyclosporine, certain antivirals (e.g., protease inhibitors), fibrates, niacin in lipid-lowering doses, warfarin or other anticoagulants, or other medicines that may increase the risk of muscle or liver side effects.
• Consult your doctor before use if pregnant, nursing, taking medications, or have medical conditions such as liver disease, kidney disease, thyroid disorders, diabetes, or muscle disorders.
• Not intended to diagnose, treat, cure, or prevent any disease without medical supervision. This is a prescription medicine and must be used under the guidance of a healthcare professional.
• Keep out of reach of children. Accidental ingestion by children requires immediate medical attention.

Side Effects:

• Common side effects may include headache, dizziness, abdominal pain, nausea, constipation, diarrhea, flatulence, fatigue, or weakness.
• Muscle-related side effects such as muscle pain, tenderness, or weakness (myalgia) can occur. In rare cases, severe muscle breakdown (rhabdomyolysis) with kidney damage may develop. Seek urgent medical attention if you experience severe, persistent muscle symptoms, dark urine, or unexplained fever.
• Possible increases in liver enzymes (transaminases) may occur; your doctor may order blood tests to monitor liver function.
• Less common side effects may include rash, itching, joint pain, or allergic reactions. Stop the medicine and seek medical help if you develop swelling of the face, lips, tongue, or throat, difficulty breathing, or severe skin reactions.
• This is not a complete list of side effects. Always read the patient information leaflet and consult your doctor or pharmacist if you notice any unusual symptoms or if side effects are severe or persistent.

Storage Instructions:

Store in a cool, dry place away from direct sunlight and moisture. Keep the blister pack in the outer carton to protect from light. Do not store above the temperature specified on the package (refer to the official pack; specific temperature is not available in the provided data). Keep container tightly closed and keep out of reach of children.

Specifications:

• Product type: Prescription lipid-lowering medicine (anti-hyperlipidemic).
• Active ingredients: rosuvastatin 10 mg + ezetimibe 10 mg per film-coated tablet.
• Form: Film-coated tablet.
• Pack size: 28 film-coated tablets per pack.
• Intended users: Adults and suitable adolescents as prescribed by a physician.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.