Cholerose Plus 20/10 28Tab

Cholerose Plus 10/20 Mg 28 Tablets

Description:

Cholerose Plus 10/20 mg is a prescription lipid-lowering medication combining rosuvastatin and ezetimibe in film-coated tablets. It is used to reduce high cholesterol and triglyceride levels and to help prevent cardiovascular events such as heart attack and stroke in appropriate patients. By inhibiting both hepatic cholesterol synthesis (via rosuvastatin, a potent statin) and intestinal cholesterol absorption (via ezetimibe), Cholerose Plus provides dual, complementary control of blood lipids for adults who require intensive cholesterol management alongside diet and lifestyle modification.

Indications:

• Treatment of primary hypercholesterolemia (high total cholesterol and/or high LDL-cholesterol) in adults, including mixed dyslipidemia, as an adjunct to diet and lifestyle changes.
• Management of patients not adequately controlled with statin therapy alone and who may benefit from additional LDL-cholesterol reduction.
• Reduction of elevated LDL-cholesterol, total cholesterol, non-HDL cholesterol, apo B and triglycerides, and increase of HDL-cholesterol where clinically indicated.
• Prevention of cardiovascular complications in high-risk patients with dyslipidemia when used as part of a comprehensive cardiovascular risk reduction strategy (diet, exercise, weight control, smoking cessation).

Active Ingredients / Key Components:

• Rosuvastatin – 10 mg per film-coated tablet (exact concentration confirmed from product name; full excipient list not available).
• Ezetimibe – 20 mg per film-coated tablet (exact concentration confirmed from product name; full excipient list not available).
• Other inactive ingredients (excipients, film-coating agents, stabilizers) – detailed composition not available in the provided data. Refer to the official package insert for the complete ingredient list.

Dosage & Administration / How to Use:

• Usual dose: One Cholerose Plus 10/20 mg film-coated tablet once daily, or as directed by your physician based on your lipid profile and cardiovascular risk.
• Administration: Swallow the tablet whole with a glass of water. Do not crush, chew, or split the film-coated tablet.
• With or without food: Can be taken with or without food, preferably at the same time each day to help adherence.
• Baseline and ongoing monitoring: Lipid levels, liver function tests, and if indicated creatine kinase (CK) should be checked according to your doctor’s recommendations.
• Missed dose: If you miss a dose, take it as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not take a double dose.
• Concomitant therapy: Inform your doctor about all other medicines you are taking, especially other lipid-lowering agents (e.g. fibrates, niacin), anticoagulants, immunosuppressants, and any drugs that may interact with statins.
• Duration of use: Long-term therapy is usually required for chronic hyperlipidemia. Do not stop treatment without consulting your physician, even if you feel well.
• Lifestyle: Use in combination with a cholesterol-lowering diet, regular physical activity, weight management, and smoking cessation for optimal cardiovascular protection.

Clinical Benefits:

• Provides dual cholesterol control by blocking both liver cholesterol production (rosuvastatin) and intestinal cholesterol absorption (ezetimibe) for enhanced LDL reduction.
• Helps significantly lower LDL-cholesterol ("bad" cholesterol), total cholesterol, and non-HDL cholesterol in patients with primary hypercholesterolemia or mixed dyslipidemia.
• Can reduce triglyceride levels and modestly increase HDL-cholesterol ("good" cholesterol), supporting a healthier lipid profile.
• Supports reduction of cardiovascular risk (such as heart attack and stroke) when used as part of a comprehensive risk management plan in high-risk patients.
• Offers a convenient once-daily tablet combining two lipid-lowering mechanisms, which may improve adherence compared with taking separate agents.

Warnings & Contraindications:

• Contraindicated in patients with active liver disease or unexplained persistent elevations in serum transaminases.
• Contraindicated in patients with known hypersensitivity to rosuvastatin, ezetimibe, or any component of the formulation.
• Contraindicated during pregnancy and breastfeeding. Women of childbearing potential should use effective contraception while on therapy.
• Use with caution in patients with a history of liver disease, heavy alcohol use, kidney impairment, thyroid disorders, or previous statin-associated muscle problems.
• Risk of myopathy and rhabdomyolysis: Report unexplained muscle pain, tenderness, or weakness, especially if accompanied by malaise or fever, to your doctor immediately.
• Monitor liver function tests before starting treatment and periodically thereafter as advised by your physician.
• Potential drug interactions: Use cautiously with fibrates, niacin at lipid-lowering doses, certain antivirals, immunosuppressants, and other medicines that may increase statin levels or muscle toxicity risk.
• Consult your doctor before use if pregnant, nursing, planning pregnancy, taking other medications, or if you have medical conditions such as liver disease, kidney disease, diabetes, thyroid disorders, or muscle disorders.
• Not intended for use in children unless specifically prescribed by a specialist.
• Keep out of reach of children.

Side Effects:

• Common side effects may include headache, dizziness, abdominal pain, nausea, constipation, diarrhea, flatulence, or fatigue.
• Muscle-related effects such as myalgia (muscle pain), muscle tenderness, or weakness can occur. Rarely, serious muscle breakdown (rhabdomyolysis) with kidney damage may develop; seek urgent medical attention if you notice severe muscle pain, dark urine, or unexplained weakness.
• Possible increases in liver enzymes may occur; your doctor may monitor blood tests and adjust or discontinue treatment if needed.
• Allergic reactions (rash, itching, swelling, difficulty breathing) are rare but require immediate medical attention.
• This is not a complete list of side effects. Always read the patient leaflet and consult your healthcare provider if you experience any unusual or persistent symptoms.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed. Keep out of reach of children.

Specifications:

• Product type: Prescription lipid-lowering medicine (statin plus cholesterol absorption inhibitor).
• Strength: 10 mg rosuvastatin + 20 mg ezetimibe per film-coated tablet.
• Form: Film-coated tablet.
• Pack size: 28 tablets per pack.
• Intended use: Adult patients requiring intensive cholesterol management as prescribed by a physician.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.