Xithrone 500 Mg 3 Tablets

Xithrone 500 Mg 3 Tablets

Description:

Xithrone 500 mg 3 tablets is a prescription systemic antibiotic medicine containing azithromycin, a semi-synthetic macrolide of the azalide class. It is used to treat a wide range of bacterial infections affecting the respiratory tract, skin and soft tissues, and certain sexually transmitted infections. Azithromycin works by binding to the 50S subunit of bacterial ribosomes, inhibiting RNA-dependent protein synthesis and stopping bacterial growth. Xithrone is manufactured by Amoun and is commonly prescribed as a short-course, once-daily oral treatment for adults and adolescents as directed by a physician.

Indications:

• Upper and lower respiratory tract infections caused by susceptible bacteria (e.g. acute bronchitis, community-acquired pneumonia, sinusitis, pharyngitis, tonsillitis).
• Skin and soft tissue infections (e.g. uncomplicated skin infections, cellulitis, infected dermatitis) due to susceptible organisms.
• Uncomplicated genital infections due to Chlamydia trachomatis (e.g. chlamydial urethritis, cervicitis) as part of physician-directed therapy.
• Uncomplicated gonorrhoea (as a single-dose regimen when prescribed by a specialist and according to local guidelines).
• Sexually transmitted infections such as chancroid and granuloma inguinale when indicated and under specialist supervision.
• Typhoid fever when azithromycin is considered appropriate according to local resistance patterns and physician judgment.
• Prophylaxis and treatment of disseminated Mycobacterium avium complex (MAC) infections in high-risk or immunocompromised patients, in combination with other antimycobacterial agents as prescribed.
• Other susceptible bacterial infections as determined by culture, sensitivity testing, and physician assessment.

Active Ingredients / Key Components:

• Azithromycin – 500 mg per film-coated tablet.
• Excipients: film-coating and tablet core excipients (exact excipient list and concentrations , please check the product leaflet or the manufacturer’s official website; please refer to the official package insert for full details).

Dosage & Administration / How to Use:

• Xithrone 500 mg tablets are for oral use only and should be taken exactly as prescribed by your doctor.
• General adult dosing examples (may vary by indication and local guidelines – follow your doctor’s instructions):
  • Respiratory tract, skin and soft tissue infections: 500 mg once daily for 3 days, or 500 mg on day 1 followed by 250 mg once daily on days 2 to 5.
  • Typhoid fever: 500 mg once daily for 7 days.
  • Uncomplicated gonorrhoea: 2 g as a single oral dose (requires multiple tablets; regimen must be set by a physician).
  • Granuloma inguinale: initial dose 1 g, then 500 mg once daily until all lesions have completely healed.
  • Chancroid / chlamydial urethritis: 1 g as a single oral dose.
  • Prophylaxis of disseminated MAC infections: 1.2 g once weekly.
  • Treatment or secondary prophylaxis of MAC (with other antimycobacterials): 500 mg once daily.
• Administration: Tablets may be taken with or without food; taking with food may reduce gastrointestinal discomfort.
• Swallow the tablet whole with a sufficient amount of water; do not crush or chew unless your doctor or pharmacist advises otherwise.
• Duration of therapy depends on the type and severity of infection and should not be altered without medical advice.
• If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to make up for a missed dose.

Clinical Benefits:

• Broad-spectrum antibacterial activity against many common respiratory, skin, and genital pathogens when they are susceptible to azithromycin.
• Convenient once-daily dosing and short treatment courses, which may improve patient adherence to therapy.
• Good tissue penetration and prolonged half-life (approximately 68 hours), allowing sustained antibacterial levels at the site of infection.
• Useful alternative in patients who cannot tolerate certain other antibiotics, when appropriate and as guided by susceptibility testing.

Warnings & Contraindications:

• Contraindicated in patients with known hypersensitivity to azithromycin, other macrolide or ketolide antibiotics, or any component of the formulation.
• Use with caution in patients with pre-existing liver disease or significant hepatic impairment, as azithromycin is primarily eliminated by the liver.
• Use with caution in patients with renal impairment, clinically significant bradycardia, cardiac arrhythmias, or prolonged QT interval, or those taking other medicines that may prolong QT interval.
• May cause Clostridioides difficile-associated diarrhea; if severe or persistent diarrhea occurs, contact your doctor immediately.
• Azithromycin may interact with other medications (e.g. certain antiarrhythmics, warfarin, digoxin, ergot derivatives); inform your doctor and pharmacist about all medicines and supplements you are taking.
• Consult your doctor before use if pregnant or planning pregnancy. Azithromycin should be used during pregnancy only if clearly needed and prescribed.
• Consult your doctor before use if breastfeeding; azithromycin passes into breast milk, and the benefit-risk should be evaluated by a healthcare professional.
• Not intended for self-medication or over-the-counter use; use only under medical supervision.
• Do not use for viral infections such as common cold or influenza.
• Consult your doctor before use if you have liver disease, kidney disease, heart disease, electrolyte disturbances (low potassium or magnesium), myasthenia gravis, or a history of severe allergic reactions to antibiotics.
• Keep out of reach of children.

Side Effects:

• Common side effects may include nausea, vomiting, abdominal pain, diarrhea, flatulence, indigestion, and headache.
• Less common side effects can include dizziness, taste disturbances, skin rash, itching, and transient changes in liver function tests.
• Serious but rare side effects may include severe allergic reactions (anaphylaxis, angioedema), severe skin reactions (Stevens–Johnson syndrome, toxic epidermal necrolysis), liver dysfunction or hepatitis, arrhythmias, QT prolongation, and Clostridioides difficile-associated diarrhea.
• Stop taking the medicine and seek immediate medical attention if you experience difficulty breathing, swelling of the face or throat, severe skin rash, yellowing of the skin or eyes, severe or bloody diarrhea, chest pain, or palpitations.
• If any side effects become bothersome or you notice any other unusual symptoms, contact your doctor or pharmacist.

Storage Instructions:

Store in a cool, dry place away from direct sunlight and moisture. Keep the blister pack tightly closed until use. Do not store above the temperature specified on the package (refer to the official pack; exact storage temperature is not available in the provided information). Keep out of reach of children.

Specifications:

• Product type: Prescription systemic antibiotic medicine.
• Active ingredient: Azithromycin 500 mg per film-coated tablet.
• Form: Film-coated tablets for oral use.
• Pack size: 3 tablets per pack.
• Intended users: Adults and adolescents as prescribed by a healthcare professional.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.