Xithrone 500 Mg 5 Tablets

Xithrone 500 Mg 5 Tablets

Description:

Xithrone 500 mg 5 tablets is a prescription systemic antibiotic medicine containing azithromycin, a semi-synthetic macrolide of the azalide class. It is used to treat a wide range of bacterial infections affecting the respiratory tract, skin and soft tissues, and certain sexually transmitted and gastrointestinal infections. Azithromycin works by inhibiting bacterial protein synthesis, helping to stop the growth of susceptible bacteria and resolve infection. This product is intended for use under medical supervision and is not effective against viral infections such as the common cold or flu.

Indications:

• Upper and lower respiratory tract infections (e.g. pharyngitis, tonsillitis, sinusitis, bronchitis, community-acquired pneumonia) caused by susceptible bacteria.
• Skin and soft tissue infections caused by susceptible organisms.
• Typhoid fever (enteric fever) as directed by a physician.
• Uncomplicated gonorrhoea (single-dose therapy as prescribed).
• Granuloma inguinale (donovanosis) as part of physician-directed therapy.
• Chancroid and chlamydial urethritis/cervicitis (single-dose therapy as prescribed).
• Prophylaxis of disseminated Mycobacterium avium complex (MAC) infections in high-risk patients, and treatment/secondary prophylaxis in combination with other antimycobacterial agents, as directed by a specialist.
• Other infections caused by azithromycin-susceptible bacteria, according to physician judgment and local guidelines.

Active Ingredients / Key Components:

• Azithromycin – 500 mg per film-coated tablet.
• Each pack contains 5 film-coated tablets for oral use.
• Excipients (tablet core and coating) are present but detailed inactive ingredient information is not available in the provided data.

Dosage & Administration / How to Use:

• Use only as prescribed by a physician. Do not self-medicate or change the dose without medical advice.
• General adult oral dosing examples (for reference; your doctor will determine the exact regimen):
  • Respiratory tract, skin and soft tissue infections: 500 mg once daily for 3 days, or 500 mg on day 1 followed by 250 mg once daily on days 2 to 5.
  • Typhoid fever: 500 mg once daily for 7 days.
  • Uncomplicated gonorrhoea: 2 g as a single oral dose.
  • Granuloma inguinale: 1 g initially, then 500 mg once daily until all lesions have completely healed.
  • Chancroid / chlamydial urethritis or cervicitis: 1 g as a single oral dose.
  • Prophylaxis of disseminated MAC infection: 1.2 g once weekly.
  • Treatment or secondary prophylaxis of MAC (with other antimycobacterials): 500 mg once daily.
• Tablets are taken by mouth with a full glass of water. They may be taken with or without food; taking with food may reduce gastrointestinal discomfort.
• Take the dose at the same time each day for best effect.
• Complete the full course as prescribed, even if symptoms improve earlier, to reduce the risk of recurrence and antibiotic resistance.
• If a dose is missed, take it as soon as you remember unless it is almost time for the next dose. Do not double the dose to make up for a missed one.
• Not recommended for children unless specifically prescribed and dosed by a pediatrician.

Clinical Benefits:

• Provides broad-spectrum antibacterial activity against many common respiratory, skin, and sexually transmitted pathogens.
• Convenient once-daily dosing and short treatment courses, which may improve adherence compared to some other antibiotics.
• Achieves high tissue concentrations and has a long half-life (approximately 68 hours), supporting sustained antibacterial effect.
• Useful alternative in patients allergic to certain other antibiotic classes (e.g. penicillins), when appropriate and as assessed by a physician.

Warnings & Contraindications:

• Contraindicated in patients with known hypersensitivity to azithromycin, other macrolide or ketolide antibiotics, or any component of the formulation.
• Use with caution in patients with pre-existing liver disease or impaired liver function, as azithromycin is primarily eliminated via the liver.
• Use with caution in patients with kidney impairment, significant cardiac disease, history of arrhythmias, or known QT interval prolongation, and in those taking other QT-prolonging drugs.
• May cause Clostridioides difficile-associated diarrhea; if severe or persistent diarrhea occurs, contact a doctor immediately.
• May interact with other medicines (e.g. certain antacids, warfarin, digoxin, some antiarrhythmics, ergot derivatives). Inform your doctor and pharmacist about all medications and supplements you are taking.
• Consult your doctor before use if pregnant or planning pregnancy. Azithromycin should be used during pregnancy only if clearly needed and prescribed.
• If breastfeeding, consult your doctor; azithromycin passes into breast milk and the benefit-risk should be assessed.
• Not intended for viral infections such as colds or influenza.
• Do not share this antibiotic with others, even if they have similar symptoms.
• Consult your doctor before use if you have liver disease, kidney disease, heart rhythm disorders, myasthenia gravis, or electrolyte disturbances (low potassium or magnesium).
• Keep out of reach of children.
• Not intended to diagnose, treat, cure, or prevent any disease without proper medical supervision.

Side Effects:

• Common side effects may include nausea, vomiting, abdominal pain, diarrhea, flatulence, indigestion, and headache.
• Less common effects can include dizziness, taste disturbances, rash, itching, and mild, transient elevations in liver enzymes.
• Serious but rare side effects may include severe allergic reactions (anaphylaxis, angioedema), severe skin reactions (Stevens–Johnson syndrome, toxic epidermal necrolysis), liver dysfunction or hepatitis, QT prolongation and serious cardiac arrhythmias, and Clostridioides difficile-associated colitis.
• Stop the medicine and seek immediate medical attention if you experience difficulty breathing, swelling of the face or throat, severe skin rash, yellowing of the skin or eyes, dark urine, severe or bloody diarrhea, chest pain, palpitations, or fainting.

Storage Instructions:

Store in a cool, dry place away from direct sunlight. Keep container tightly closed in its original blister and carton to protect from moisture. Keep out of reach of children. Do not use after the expiry date printed on the pack.

Specifications:

• Product type: Prescription systemic antibiotic medicine (oral).
• Active ingredient strength: azithromycin 500 mg per film-coated tablet.
• Count and form: 5 film-coated tablets per pack.
• Route of administration: Oral.
• Intended users: Adults and adolescents as prescribed by a healthcare professional.

Disclaimer:
All pharmacy products are intended for general use only and do not replace professional medical advice, diagnosis, or treatment. Always consult a healthcare provider before use. Results may vary, and no specific outcomes are guaranteed. Products are not intended to diagnose, treat, cure, or prevent any disease unless stated. Follow label instructions carefully, as misuse may cause adverse effects. Compliance with local laws is the customer’s responsibility.